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Glutathione/ultrasound dual stimulation response nano polymer vesicles and preparation method and application thereof

A dual-stimuli-response, nano-polymer technology, applied in the field of biomedicine, can solve problems such as low dosage and human side effects, and achieve the effects of reducing side effects, good comprehensiveness, and clear and concise preparation process

Active Publication Date: 2017-09-12
HARBIN INST OF TECH WUXI RES INST OF NEW MATERIALS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dose to reach the tumor tissue through the body fluid circulation after direct injection is very low, and it will bring serious side effects to the human body.

Method used

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  • Glutathione/ultrasound dual stimulation response nano polymer vesicles and preparation method and application thereof
  • Glutathione/ultrasound dual stimulation response nano polymer vesicles and preparation method and application thereof
  • Glutathione/ultrasound dual stimulation response nano polymer vesicles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) Add 1g of calcium chloride, 22.5ml of solvent N-methylpyrrolidone and 2.5ml of pyridine into the reaction bulb, slowly heat to 70°C, and stir to dissolve it completely. Subsequently, 2.68 g of sodium isophthalic acid-5-sulfonate and 5.24 ml of triphenyl phosphite were added to the solution, and after they were completely dissolved, 1.16 g of hexamethylenediamine was added. Then turn off the temperature controller, and after the solution is cooled, pump it out three times, and replace the air in the system with nitrogen. Under the inert atmosphere of the system, heating was started to raise the temperature to 95° C., and the reaction was carried out for 3 hours. A hydrophilic polyamide segment is obtained.

[0031] 2) Add 1g of calcium chloride, 22.5ml of N-methylpyrrolidone and 2.5ml of pyridine into another reaction bulb, slowly heat to 70°C, and stir to dissolve them completely. Subsequently, 2.10 g of 3,3'-dithiodipropionic acid and 5.24 mL of triphenyl phosphit...

Embodiment 2

[0035] 1) Add 0.5g of magnesium chloride and 0.52g of lithium chloride, 13.2ml of solvent N-methylpyrrolidone and 3.8ml of pyridine into the reaction bulb, slowly heat to 40°C, and stir to dissolve them completely. Subsequently, 2.68 g of sodium isophthalic acid-5-sulfonate and 5.24 ml of triphenyl phosphite were added to the solution, and after they were completely dissolved, 0.6 g of ethylenediamine was added. Then turn off the temperature controller, and after the solution is cooled, pump it out three times, and replace the air in the system with nitrogen. Under the inert atmosphere of the system, heating was started to raise the temperature to 100° C., and the reaction was carried out for 20 hours. A hydrophilic polyamide segment is obtained.

[0036] 2) Add 0.2g of calcium chloride and 0.2g of lithium chloride, 6.22ml of N-methylpyrrolidone and 1.78ml of pyridine into another reaction bulb, slowly heat to 40°C, and stir to dissolve them completely. Subsequently, 1.225 g...

Embodiment 3

[0040] 1) Add 0.5g of calcium chloride and 0.5g of lithium chloride, 8.89ml of solvent N-methylpyrrolidone and 1.11ml of pyridine into the reaction bulb, slowly heat to 70°C, and stir to dissolve them completely. Subsequently, 2.68 g of sodium terephthalate-5-sulfonate and 5.24 ml of triphenyl phosphite were added to the solution, and after they were completely dissolved, 0.88 g of butanediamine was added. Then turn off the temperature controller, and after the solution is cooled, pump it out three times, and replace the air in the system with nitrogen. Under the inert atmosphere of the system, heating was started to raise the temperature to 105° C., and the reaction was carried out for 12 hours. A hydrophilic polyamide segment is obtained.

[0041] 2) Add 0.5g of calcium chloride and 0.1g of lithium chloride, 5.56ml of N-methylpyrrolidone and 4.44ml of pyridine into another reaction bulb, slowly heat to 70°C, and stir to dissolve them completely. Subsequently, 0.9 g of thio...

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Abstract

The invention discloses glutathione / ultrasound dual stimulation response nano polymer vesicles and a preparation method and application thereof. The preparation method of the nano polymer vesicles is characterized by including steps: preparing hydrophilic polyamide chain segments and hydrophobic polyamide chain segments, subjecting the hydrophilic polyamide chain segments and the hydrophobic polyamide chain segments to mixed reaction to prepare segmented polyamide, and further preparing nano polymer vesicle solution of the segmented polyamide. The nano polymer vesicles prepared according to the method have a characteristic of stimulation response to glutathione and ultrasound and are excellent in degradability.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a glutathione / ultrasound dual stimulation-responsive nanometer polymer vesicle, its preparation method and application. Background technique [0002] According to a large number of studies, doxorubicin is an effective anticancer drug, which can inhibit the synthesis of RNA and DNA, has the strongest inhibitory effect on RNA, has a wide antitumor spectrum, and can kill tumor cells in various growth cycles. Killing effect. However, the dose to reach the tumor tissue through body fluid circulation after direct injection is very low, and it will bring serious side effects to the human body. There have been many studies in the world to develop target-targeted drug delivery systems (drug delivery systems, DDS) to enhance drug efficacy and reduce side effects. These drug carriers include various forms of nanoparticles, micelles, microcapsules, and nanovesicles. Wait. [0003] Polymersomes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/42C08K5/523C08K3/16C08L77/00A61K9/127A61K47/34A61K31/704A61P35/00
CPCA61K9/0009A61K9/1273A61K31/704A61K47/34C08G69/42C08K3/16C08K5/523C08K2003/162C08L2205/02C08L77/00
Inventor 白永平王利鹏黄磊李卫东席丹殷晓芬
Owner HARBIN INST OF TECH WUXI RES INST OF NEW MATERIALS
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