A kind of preparation method of high-content omega-3 fatty acid ethyl ester

A fatty acid ethyl ester, high-content technology, applied in the preparation of carboxylate, oil/fat refining, and preparation of organic compounds, etc. The effect of short heating time, good quality and high yield

Active Publication Date: 2021-11-23
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The combined rectification-molecular distillation system of the present invention overcomes the disadvantages of low molecular distillation separation efficiency and long heating of the rectification tower equipment

Method used

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  • A kind of preparation method of high-content omega-3 fatty acid ethyl ester

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Experimental program
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Effect test

Embodiment 1

[0025]The combined rectification-molecular distillation system of the present invention is suitable for the separation and purification of heat-sensitive polyunsaturated fatty acids by integrating the respective advantages of rectification and molecular distillation. The working process of this rectification-molecular distillation combined system is as follows: the material flow 1 obtained after the alcoholysis and degassing of anchovy oil, the content of EPA ethyl ester in material 1 is 19.5%, and the content of DHA ethyl ester is 10.0%; Stage rectification column C10 is rectified and separated into light component 3 and heavy component 4. The bottom material is pumped and circulated, enters the bottom reboiler 2 for heating and then refluxes into the rectification column C10. The reboiler is a falling film type , the heating temperature is 180-200 DEG C [the temperature here is the heating temperature of the reboiler (equivalent to the temperature of the tower kettle), and th...

Embodiment 2

[0028] Material stream 1 obtained after alcoholysis and degassing of miscellaneous fish oil (mixed fish oil of anchovy oil and sardine oil), the content of EPA ethyl ester in material 1 is 17.6%, and the content of DHA ethyl ester is 12.8%; firstly, through the first stage of rectification Column C10 is rectified and separated into light component 3 and heavy component 4. The material at the bottom of the tower is pumped and circulated, enters the reboiler 2 at the bottom of the tower to be heated, and then refluxes into the rectification tower C10. The reboiler is a falling film type, and the heating temperature is The temperature at the top of the tower is 180°C, the vacuum at the top of the tower is 10-20Pa, and the temperature at the top of the tower is 140-180°C; the heavy component 4 is separated from the light component 5 and the heavy component 6 through the second-stage molecular evaporator C20, and the light component 5 is High content of EPA ethyl ester, the content ...

Embodiment 3

[0030] The material stream 1 obtained after alcohol hydrolysis and degassing of tuna oil, the content of EPA ethyl ester in material 1 is 6.6%, the content of DHA ethyl ester is 24.8%; firstly, it is separated into light component 3 by rectification of the first stage rectification column C10 And heavy component 4, the material at the bottom of the tower is pumped and circulated, enters the reboiler 2 at the bottom of the tower to be heated, and then refluxes into the rectification tower C10. -20Pa, the temperature at the top of the tower is 140-180°C; the heavy component 4 passes through the second-stage molecular evaporator C20 to separate the light component 5 and the heavy component 6, in which the light component 5 is high-content Omega-3 ethyl ester, which The content of EPA ethyl ester + DHA ethyl ester is 65.7%, and the ratio of EPA ethyl ester and DHA ethyl ester can be adjusted by heating temperature. When the heating temperature of C20 is 150-160°C, DHA ethyl ester:E...

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Abstract

The invention provides a method for preparing high-content Omega-3 fatty acid ethyl ester, using fish oil ethyl ester as a raw material, through the first-stage rectification, the second and third-stage molecular distillation combined processes, respectively in the second and third stages The molecular distillation light phase outlet receives EPA ethyl ester and DHA ethyl ester components, thereby obtaining high-content EPA ethyl ester and DHA ethyl ester products. Because the fractions are subdivided by the method of the present invention, the ratio of EPA ethyl ester and DHA ethyl ester can be adjusted at will, greatly improving the value of the product, expanding the scope of application, and can be used as nutritional supplements, medicines, and food-grade food additives. High economic value.

Description

technical field [0001] The present invention generally relates to the concentration of omega-3 fatty acid ethyl esters from fatty acid ethyl ester mixtures using a rectification-molecular distillation coupled process. Background technique [0002] Deep-sea fish oil is rich in polyunsaturated fatty acids (PUFA), among which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the main ones, which are two very important fatty acids for the human body. Because of its inability to be synthesized in the human body and its unique physiological activity, its health care function and nutritional value have been paid more and more attention by people. EPA and DHA have the functions of lowering cholesterol and blood lipids, delaying thrombus formation, inhibiting platelet aggregation, and preventing arteriosclerosis and Alzheimer's disease. DHA also has the functions of maintaining eyesight, promoting the growth and development of brain cells, and improving brain function. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/54C07C69/587C11B3/12
CPCC07C67/54C07C69/587C11B3/12
Inventor 代志凯李祥清何国军王升帆许新德邵斌
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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