Synthetic technology for ofloxacin
A synthesis process, ofloxacin technology, applied in the field of ofloxacin synthesis process, can solve the problems of reduced yield, long chemical synthesis route, and reduced content of final products, so as to reduce the loss of intermediates and improve the condensation reaction Yield, the effect of reducing the discharge of three wastes
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Embodiment 1
[0020] The present invention proposes a kind of synthetic technique of ofloxacin, comprises the steps:
[0021] S1. Choose (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridine[1,2,3-de][1, 4) Benzazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10-difluoro-2,3-dihydro-3 Molar mass of -methyl-7-oxo-7-hydropyridine[1,2,3-de][1,4]benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide The ratio is 1:1:3, and sealed storage;
[0022] S2. Select the reactor as an auxiliary tool, and weigh (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7oxo-7hydropyridine in proportion [1 , 2,3-de] [1,4] benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10- Difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridinium[1,2,3-de][1,4]phenazine-6-carboxylic acid, N-methyl Piperazine and dimethyl sulfoxide were sequentially added to the reactor, heated and stirred for 4 hours under an e...
Embodiment 2
[0033] The present invention proposes a kind of synthetic technique of ofloxacin, comprises the steps:
[0034] S1. Choose (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridine[1,2,3-de][1, 4) Benzazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10-difluoro-2,3-dihydro-3 Molar mass of -methyl-7-oxo-7-hydropyridine[1,2,3-de][1,4]benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide The ratio is 1:1:3, and sealed storage;
[0035] S2. Select the reactor as an auxiliary tool, and weigh (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7oxo-7hydropyridine in proportion [1 , 2,3-de] [1,4] benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10- Difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridinium[1,2,3-de][1,4]phenazine-6-carboxylic acid, N-methyl Piperazine and dimethyl sulfoxide were sequentially added to the reactor, heated and stirred for 5 hours under an e...
Embodiment 3
[0046] The present invention proposes a kind of synthetic technique of ofloxacin, comprises the steps:
[0047] S1. Choose (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridine[1,2,3-de][1, 4) Benzazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10-difluoro-2,3-dihydro-3 Molar mass of -methyl-7-oxo-7-hydropyridine[1,2,3-de][1,4]benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide The ratio is 1:1:3, and sealed storage;
[0048] S2. Select the reactor as an auxiliary tool, and weigh (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7oxo-7hydropyridine in proportion [1 , 2,3-de] [1,4] benzoperazine-6-carboxylic acid, N-methylpiperazine, dimethyl sulfoxide as raw materials, and (S)-(-)-9,10- Difluoro-2,3-dihydro-3-methyl-7-oxo-7hydropyridinium[1,2,3-de][1,4]phenazine-6-carboxylic acid, N-methyl Piperazine and dimethyl sulfoxide were sequentially added to the reactor, heated and stirred for 7 hours under an e...
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