A surface-enhanced Raman substrate material for detecting nitrite and its preparation method

A surface-enhanced Raman and nitrite technology, applied in the field of analysis and detection, can solve the problems of long time, complicated operation, complicated equipment, etc., and achieve the effect of low cost, simple method and strong surface.

Inactive Publication Date: 2019-07-19
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nitrite is closely related to our life. Traditional detection methods include liquid chromatography, gas chromatography-mass spectrometry, kits, etc. These methods are complicated to operate, take a long time and the instruments are expensive
Chinese patent application (CN102519890A) detects nitrite ion by the diazotization reaction of benzidine or its derivatives, although this method is simple, this invention has certain limitations
When the detected sample is not analytically pure, purification is required; when the conditions are not mild, complex equipment is required, which is uneconomical

Method used

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  • A surface-enhanced Raman substrate material for detecting nitrite and its preparation method
  • A surface-enhanced Raman substrate material for detecting nitrite and its preparation method
  • A surface-enhanced Raman substrate material for detecting nitrite and its preparation method

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Embodiment 1

[0026] Example 1 Preparation of surface-enhanced Raman base material

[0027] (1) Preparation of gold nanorods by seed method:

[0028] a. Preparation of gold nano seed solution: At room temperature (20-25℃), prepare 9.75mL 0.1mol / L cetylammonium bromide aqueous solution, stir evenly until transparent, and add 0.25mL 0.01mol / L chloroauric acid dropwise Aqueous solution, after it is evenly dispersed in the solution, quickly add 0.6mL of a freshly prepared 0.01mol / L sodium borohydride solution (ice water bath), the solution changes from light yellow to brown, stir evenly for 3 minutes, and stand at room temperature for 2 hours before use .

[0029] b. Preparation and purification of gold nanorod solution: at room temperature, prepare 10mL 0.1mol / L cetyltrimethylammonium bromide aqueous solution, and then add 0.5mL 0.01mol / L chloroauric acid aqueous solution, and mix well. Add 0.1mL 0.01mol / L silver nitrate, 0.2mL mol / L hydrochloric acid, stir well, add 80μL 0.1mol / L ascorbic acid, th...

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Abstract

The invention discloses a surface enhanced Raman substrate material for detecting nitrite and a preparation method thereof. The preparation method comprises the following specific steps: (1) synthesizing a gold nano-rod by a crystal seed method; (2) preparing a p-mercaptoaniline modified gold nano-rod material; (3) synthesizing a gold nano-sphere by a hydrothermal method; (4) preparing a 1-amino-8-metcaptonaphthalene modified gold nano-sphere composite material; (5) mixing the p-mercaptoaniline modified gold nano-rod material and nitrite to generate diazonium salt; (6) mixing the diazonium salt and the 1-amino-8-metcaptonaphthalene modified gold nano-sphere composite material to generate azo-dye; (7) indirectly carrying out qualitative and quantitative detection on the nitrite by utilizing a surface enhanced Raman spectrum signal of the azo-dye. The surface enhanced Raman substrate material disclosed by the invention has good surface enhanced Raman activity on a substrate and can be used for rapidly detecting the nitrite in the environment and food samples.

Description

Technical field [0001] The invention belongs to the technical field of analysis and detection, and specifically relates to a surface-enhanced Raman substrate material for detecting nitrite and a preparation method thereof. Background technique [0002] Nitrite is widely present in the human environment. The nitrate in the human body can be reduced to nitrite under the action of microorganisms; it can be used as a color protectant for meat products in the food industry, and is often added to bacon and ham to increase its color. Make it beautiful; it can also be used as a preservative. The color and taste of nitrite are similar to those of table salt, making it difficult to distinguish. High doses of nitrite are very toxic and will affect the operation of red blood cells, leading to hypoxia and death. Under conditions such as cooking, nitrite and amino acids degrade and react to produce nitrosamines, which are highly carcinogenic. Nitrite is closely related to our lives. The tra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 李丹邓维段化珍马亚丹
Owner SHANGHAI INST OF TECH
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