A kind of olfactory disorder detection kit and its application

Abstract

The invention relates to the field of detection kits and discloses a dysosmia detection kit and application thereof. The kit comprises one or more solid smell blocks formed by a solid solvent, an excipient and smell essence. The solid solvent is a solid at normal temperature, becomes liquid after being heated and can dissolve the essence. According to the kit, a solid material is adopted to serve as a smell carrier and specific essence ingredients are adaptive, liquid reagents in similar Sniffin's Sticks and a five-flavor smelling-trying liquid method are avoided, risks of liquid scattering, container damage, environmental pollution and volatilization can be reduced, and it is guaranteed that the solid smell blocks have good smell testing effects; compared with a similar B-SIT method, the kit has more excellent performance indexes, is particularly suitable for Chinese population and can be applied to auxiliary diagnosis of Parkinson's disease and preparation of relevant detection products.

Description

technical field [0001] The invention relates to the field of detection kits, in particular to a detection kit for olfactory disturbance and its application. Background technique [0002] Parkinson's disease (PD) and Alzheimer's disease (AD) are common chronic progressive neurological diseases in the elderly. The clinical features of Parkinson's disease are mainly motor symptoms (rest tremor, slow movement, muscle stiffness), accompanied by a large number of non-motor symptoms (hyposmia, constipation, depression, sleep disturbance) before and after the appearance of motor symptoms And later complications (such as balance disorders, falls, freezing phenomena, dysphagia, language barriers, etc.). Alzheimer's disease (commonly known as: senile dementia) is mainly characterized by cognitive dysfunction and memory impairment. In the early stage of the disease, that is, mild cognitive impairment (MCI) stage can also appear and cognitive impairment. Clinical manifestations of hypo...

AI Technical Summary

Problems solved by technology

However, the test tool of this method is large in volume, and the test is in the form of liquid reagents, which is not conducive to carrying and storage

In addition, the test process must be guided by professionals, and self-assessment of the subjects cannot be performed, so it is not conducive to extensive screening work

[0007] The "Five Flavors Test Smell Solution" method developed by the Institute of Semiconductors, Chinese Academy of Sciences, has been proven through clinical research that this method can be used for olfactory examination of patients with Parkinson's disease and Alzheimer's disease, but this method has some shortcomings, such as: smell The test solution is packaged in glass bottles, which are easy to break and not easy to carry; the smell is volatile and inconvenient to store; there are only 5 kinds of smells selected for the test, and none of them passed the familiarity survey at the beginning of the selection; the determination of the normal value range is only for 18 - The research data of the 25-year-old youth group is confirmed, and there is no problem such as setting the olfactory function of the normal elderly

Therefore, there is still a lack of a olfactory detection tool for patients with Parkinson's disease and Alzheimer's disease that is familiar to the Chinese population, easy to operate, easy to store, and easy to carry.

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