Preparation method of konjac glucomannan-gelatin based capsule

A technology based on konjac glucomannan and gelatin, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of excess production capacity, complicated preparation process, and high price of gelatin, and achieve strong elasticity, Uniform thickness and less air bubbles

Active Publication Date: 2017-10-20
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This makes the output of gelatin empty capsules obviously oversupply, and the production capacity is excessive, which makes the industry of gelatin empty capsules extremely intense. This phenomenon has two sides. The advantage is that it can promote the development of the entire industry and promote the development of new gelatin-based capsule shells in the in

Method used

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  • Preparation method of konjac glucomannan-gelatin based capsule
  • Preparation method of konjac glucomannan-gelatin based capsule
  • Preparation method of konjac glucomannan-gelatin based capsule

Examples

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Example Embodiment

[0033] Example 1:

[0034] A preparation method of konjac glucomannan-gelatin-based capsules includes the following steps:

[0035] Step 1. Add 0.025g of mannase to 80mL of distilled water by weight, mix well, then slowly add 10g of konjac flour to the beaker; degrade at room temperature for 10min; then add 10g of konjac flour to the beaker for degradation for 10min; Add 10g of konjac powder to the beaker and degrade it for 10min; then add 10g of konjac powder to the beaker and degrade it for 10min; adjust the pH to 10, and then inactivate it in a constant temperature water bath at 80℃ for 20min; cool to room temperature to obtain konjac Glycan degradation liquid; the content of the degradation liquid is 40 / 120=34%;

[0036] Step 2. Take the konjac glucomannan degradation solution (the content of konjac glucomannan is 4g), add glycerin, stir evenly at 70℃ and 150rpm, then add 4g gelatin, stir at 50rpm, until the degradation solution The gelatin is completely dissolved to obtain a m...

Example Embodiment

[0038] Example 2:

[0039] The amount of gelatin added is 8g, and the rest of the process and parameters are exactly the same as those in Example 1.

Example Embodiment

[0040] Example 3:

[0041] The amount of the konjac glucomannan degradation liquid added is (the content of konjac glucomannan is 8g), and the rest of the process and parameters are exactly the same as those in Example 1.

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Abstract

The invention discloses a preparation method of a konjac glucomannan-gelatin based capsule. The method includes: using mannose to degrade konjac refined powder to obtain a konjac glucomannan degradation solution; adding glycerin into the konjac glucomannan degradation solution, stirring the substances evenly, then adding gelatin, performing stirring till complete dissolution of the gelatin in the degradation solution so as to obtain mixed sol; subjecting the mixed sol to degassing, then carrying out standing glue dipping, freezing, shell pulling, cutting and drying, thus obtaining the konjac glucomannan-gelatin based capsule. The konjac glucomannan-gelatin based capsule has the characteristics of uniform capsule shell thickness, easy shell pulling and no rupture, no insert split, few bubble, no collapse, and no thin head. Strength and elastic detection of the capsule shell shows that the friability is lower than that of single gelatin capsule shell, and the elasticity is stronger. Dissolution rate detection determines the drug release effect of the konjac glucomannan-gelatin capsule, and the test finds that drug release occurs at about 4-5min, and the dissolution rate at about 60min is 95.5%.

Description

technical field [0001] The invention relates to a preparation method of capsules, in particular to a preparation method of konjac glucomannan-gelatin-based capsules. Background technique [0002] Capsules refer to preparations in which medicines are contained in empty capsules. The Chinese Pharmacopoeia defines capsules into two categories: hard capsules and soft capsules. The shape of the hard capsule is oval, which is composed of a capsule body and a cap, both of which have their own grooves and mold shapes, and can be tightly integrated into one body. Comparing capsules with tablets and other types of dosage forms, capsules are characterized by the ability to mask the bad smell of drugs, good absorption, and good stability of drugs. After more than 180 years of development, capsules have been used in oral solid preparations. It has become the main dosage form, and capsules have many advantages compared with other dosage forms, so the number of capsules in the pharmaceut...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/42A61K47/36
CPCA61K9/4816A61K9/4825
Inventor 龙晓燕罗学刚
Owner SOUTHWEAT UNIV OF SCI & TECH
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