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Ointment for treating leucoderma by combination of fluoxetine and traditional Chinese medicine component as well as preparation method thereof

A technology of fluoxetine and vitiligo, applied in the field of ointment for treating vitiligo, can solve problems such as difficult treatment, and achieve the effects of improving the cure rate and having less side effects

Inactive Publication Date: 2017-11-24
SHANDONG RUNZE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cause of Vitiligo is still unknown, so its treatment is difficult

Method used

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  • Ointment for treating leucoderma by combination of fluoxetine and traditional Chinese medicine component as well as preparation method thereof
  • Ointment for treating leucoderma by combination of fluoxetine and traditional Chinese medicine component as well as preparation method thereof
  • Ointment for treating leucoderma by combination of fluoxetine and traditional Chinese medicine component as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 10g of psoralen, 10g of Angelica dahurica, 2.0g of astragalus, 15g of tribulus terrestris, 8.0g of safflower, 8.0g of Chuanxiong, 3.0g of fig, add 40 times of water for ultrasonic extraction for 30min, then decoct and concentrate to 100g for later use; fluoxetine Dissolve 20 mg in 15 mL of propylene glycol for later use; take 0.1 mL of triethanolamine, 1.0 g of sodium lauryl sulfate, 2.0 mL of glycerin, and 50 mL of purified water, and heat in a water bath to 80°C (water phase); take another 3.0 g of stearyl alcohol, Glyceryl stearate 1.0g, stearic acid 3.0g, liquid paraffin 3.0mL, white petrolatum 1.0g, heated in a water bath to 80°C (oil phase); add the water phase to the oil phase to form a cream, and keep stirring, add The drug and 50 μL of ethylparaben were continuously stirred, and slowly cooled to room temperature to obtain fluoxetine ointment.

Embodiment 2

[0022] Weigh 15g of psoraleae, 15g of Angelica dahurica, 6.0g of astragalus, 20g of tribulus terrestris, 12g of safflower, 12g of Chuanxiong, 8.0g of fig, add 40 times of water for ultrasonic extraction for 30min, then decoct and concentrate to 100g for later use; dissolve 20mg of fluoxetine Put it in 15mL propylene glycol for later use; take 1.0mL triethanolamine, 1.0g sodium lauryl sulfate, 3mL glycerin, 50mL purified water, and heat in a water bath to 80°C (water phase); take another 5.0g stearyl alcohol, monostearic acid Glyceride 2.0g, stearic acid 5.0g, liquid paraffin 5.0mL, white petrolatum 2.0g, heated in a water bath to 80°C (oil phase); add the water phase to the oil phase to form a cream, and keep stirring, add the drug and hydroxyl Continue stirring with 50 μL of phenethyl ester, and slowly cool to room temperature to obtain fluoxetine ointment.

Embodiment 3

[0024] Weigh 15g of psoralen, 12g of Angelica dahurica, 5.0g of astragalus, 20g of tribulus, 8.0g of safflower, 10g of Chuanxiong, 5.0g of fig, add 40 times of water for ultrasonic extraction for 30min, then decoct and concentrate to 100g for later use; fluoxetine 20mg Dissolve in 15mL propylene glycol for later use; take 1.0mL triethanolamine, 1.0g sodium lauryl sulfate, 2.5mL glycerin, 50mL purified water, and heat in a water bath to 80°C (water phase); take another 3.0g stearyl alcohol, monohard Glyceryl fatty acid 3.5g, stearic acid 1.5g, liquid paraffin 3.5mL, white petrolatum 2.0g, heated in a water bath to 80°C (oil phase); add the water phase to the oil phase to form a cream, and keep stirring, add the drug Continue stirring with 50 μL of ethylparaben, and slowly cool to room temperature to obtain fluoxetine ointment.

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Abstract

The invention belongs to the technical field of a medicinal preparation, and relates to a fluoxetine ointment for treating leucoderma. The ointment is prepared by combination of Chinese traditional and western medicines. A preparation method of the ointment comprises the following steps: extracting the traditional Chinese medicinal material active ingredients by an ultrasonic method for standby, dissolving fluoxetine in propylene glycol for standby; adding a certain amount of water-phase component and an emulsifier in a certain amount of an oil-phase component for being stirred to obtain an emulsifiable paste matrix; and finally adding the medicine and an antiseptic into the matrix to obtain the finished product. The preparation method is simple, and the treatment effect is obvious.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations. Specifically relates to an ointment for treating vitiligo. Background technique [0002] Vitiligo is a relatively common acquired depigmentation disease, characterized by the lack of melanocytes in the epidermis, mucous membrane and other tissues, the incidence rate is 0.5% to 2%, and there is no obvious difference in race and gender. Its pathogenesis may be related to genetic, neuroendocrine, autoimmune and other factors. The cause of vitiligo is still unclear, so its treatment is also difficult. [0003] Fluoxetine, the Chinese alias is halothane aniline; the chemical name is N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, which is mostly in the form of hydrochloride Used as an antidepressant. as an antidepressant. Studies have shown that fluoxetine can increase the activity of cell tyrosinase (tyrosine), increase the protein levels of MITF, TYR and TRP-1, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K9/06A61P17/00A61K31/137
CPCA61K9/0014A61K9/06A61K31/137A61K36/185A61K36/232A61K36/236A61K36/286A61K36/481A61K36/487A61K36/60A61K47/44A61K2300/00
Inventor 彭继先薛洪智周志亮王辉高天虹周昕琪
Owner SHANDONG RUNZE PHARMA
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