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DUal microbial preparation for long-term suppression or prevention of symptoms of opportunistic microbial infections

A microbial infection and microbial technology, applied in medical preparations containing active ingredients, anti-infective drugs, applications, etc., can solve problems such as objections, and achieve the effect of eliminating pathogenic infection and eliminating long-term stable effects.

Inactive Publication Date: 2017-11-28
BIO AGENS RES & DEV - BARD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these same cases, the effectiveness of these preparations has only been demonstrated in laboratory tests and not in the actual context of clinical studies, causing objection

Method used

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  • DUal microbial preparation for long-term suppression or prevention of symptoms of opportunistic microbial infections
  • DUal microbial preparation for long-term suppression or prevention of symptoms of opportunistic microbial infections
  • DUal microbial preparation for long-term suppression or prevention of symptoms of opportunistic microbial infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] ( Figure 1A , Figure 1B , Figure 1C , figure 2 )

[0059] Testing Chytrá in the form of effervescent tablets in a multicenter study BioPlus, the study included 3 dental clinics and 1 clinical microbiology department. Participants in each group of studies with periodontal disease (periodontitis) gathered in 3 dental clinics in Prague and Kladno, Czech Republic, and Kosice, Slovak Republic. The Prague group consisted of 7 participants, Kladno’s group consisted of 15 participants, and Kosice’s group consisted of 22 participants. Therefore, the total number of participants in the study is 44. The control group was treated in parallel with the same method and did not receive biological products, but the classic chemical chlorhexidine gel. Research participants used PBI (papillary bleeding index) measurement for routine monitoring, which reflects the immediate conditions of gum inflammation and CPITN (Community Periodontal Treatment Needs Index), which is a measure of the ...

Embodiment 2

[0105] ( image 3 , Figure 4 )

[0106] The cosmetic Biomycosin has the active substance Pythium oligandrum, and was tested on 2 groups of diabetic and non-diabetic patients at the request of the Pardubice Regional Hospital, who had microbiologically inflamed hard-to-heal wounds. The study participants were not randomized, but their diabetes status was monitored, which allowed the data to be divided into diabetic and non-diabetic groups at the end of the study. As far as non-diabetic patients are concerned, their average age is 63.7±13.1 years, of which patients are in the range of 37-79 years. The total number of patients monitored is 19, 14 women and 5 men, because the incidence of inflammatory varicose ulcers is higher in women than in men. The administration of Biomycosin is carried out in the hospital under the supervision of medical staff. Outpatients are hospitalized during the administration phase. One pack of Biomycosin is used for 3 (every 8 hours) wet applications,...

Embodiment 3

[0133] ( Figure 5A , Figure 5B , Figure 5C , Image 6 )

[0134] Obtained convincing evidence from clinical observations in the field of oral health, difficult-to-heal wounds and the prevention of yeast in vaginal candidiasis. Pythium oligandrum inhibits and kills the pathogenic yeasts of Candida and Malassezia strains . This conclusion was subsequently independently confirmed by laboratory culture tests conducted by the Institute of Microbiology of the Czech Academy of Sciences in Prague. A total of 4 clinical strains of pathogenic yeast Candida albicans isolated from Pardubice Hospital were tested in a laboratory competition test to determine their ability to grow through hyphae as evidence of clinical invasion of these strains. The participating strains are Candida albicans 2508, 2548, 2558 and 2944. In the case where MEA (Malt Extract Agar) was used as the culture medium, Pythium oligandrum grew faster than all 4 test strains in the competition test. After 10 days of th...

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Abstract

The dual microbial preparation contains the microscopic oomycete Pythium oligandrum and components of a physiological microbiome. The microscopic oomycete Pythium oligandrum and the physiological microbiome component are present in the dual preparation in a form which facilitates their germination, subsequent propagation and colonization of the target tissues. The microscopic oomycete Pythium oligandrum is incorporated in a quantity of 103 to 107 CFU (colony forming units), with 104 to 105 CFU per one cycle of application preferably. The physiological microbiome component contains 5x 106 to 5x1010 CFU, with 5x107 to 5x109 per one cycle of application preferably. The fermented substrate found in the Pythium oligandrum oomycete is the source of nutrients for both microbial components. The dual microbial preparation also contains at least one auxiliary substance from a group including a desiccant, components of a buffer system, an anti-caking substance and an agent for the creation of a physiological osmotic environment. The physiological microbiome component is a component of the human microbiome, one of the microbes of the green complex, such as the Capnocytophaga sputigena bacterium, or one of the components of the healthy skin microbiome, such as the Staphyloccocus epidermidis bacterium, or one of the components of the healthy vaginal microbiome, such as the peroxide producing Lactobacillus crispatus. Either the microscopic oomycete Pythium oligandrum or the physiological microbiome component is present in the dual microbial preparation in the form of inactivated cells, cell extracts or isolated cell fractionation. The microbial activator for the Pythium oligandrum oomycete is a yeast autolysate in a quantity of 0.1 % to 10 % weight of the total quantity of dual microbial preparation. The auxiliary substances are regulated in a way which allows for application in the form of an ointment, cream, oil or suppository or in the form of a liquid aqueous preparation.

Description

Technical field [0001] The present invention relates to a binary microbial product for long-term suppression of opportunistic microbial infections, especially opportunistic microbial infections and symptoms caused by dysbiosis (disruption of microbial balance). Background of the invention [0002] The incidence of opportunistic microbial infections, inflamed and difficult-to-heal wounds, infections caused by invasive symbiotic yeast forms, and fungal infections caused by dermatophytes are on the rise. These problems currently affect a large part of the population. This is mainly caused by the following: the increase in the incidence of such diseases is usually not caused by external epidemiological factors or genetic defects that cause the physiological program of the host immune response to be fundamentally destroyed. At present, the main cause of opportunistic microbial infection is the temporary weakening of the immune system and natural defense response. It is most often used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K36/06A61K35/747A61K35/742A61K35/74A61K36/064A61P31/10A61P31/04A01N63/20A01N63/30
CPCA61K35/74A61K35/742A61K35/747A61K36/06A61K36/064A61K45/06A61K2300/00A61K36/02A61P11/00A61P17/02A61P25/24A61P31/00A61P31/04A61P31/10A61P37/08A61P43/00
Inventor M·沙涅克R·克利麦斯
Owner BIO AGENS RES & DEV - BARD
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