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Application of fructus gardeniae and ethanol eluting part memory-improving assisting capsules or tablets for preparing health-care foods for assisting in improving memory function

A technology that assists in improving memory and health food. It is applied in applications, capsule delivery, food ingredients, etc., to delay brain aging, assist in improving memory function, and improve sleep.

Inactive Publication Date: 2017-12-01
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned studies have not been reported yet. Through systematic in vivo and in vitro experimental studies, we first found that the eluting parts of Gardenia 30% or 80% ethanol can help improve memory. Hypertension, atherosclerosis and transient ischemic attack, etc.) caused cerebral hypoperfusion, neurological diseases, amyloid Aβ deposition or Aβ fibril aggregation and other factors caused by physiological or pathological brain aging memory in the elderly Auxiliary improvement of memory function

Method used

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  • Application of fructus gardeniae and ethanol eluting part memory-improving assisting capsules or tablets for preparing health-care foods for assisting in improving memory function
  • Application of fructus gardeniae and ethanol eluting part memory-improving assisting capsules or tablets for preparing health-care foods for assisting in improving memory function
  • Application of fructus gardeniae and ethanol eluting part memory-improving assisting capsules or tablets for preparing health-care foods for assisting in improving memory function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Gardenia fruit eluted with 30% or 80% ethanol to assist in improving memory capsules or tablet raw material components: Grind the dried gardenia fruit into a coarse powder of 20 meshes, soak in 70% ethanol for 1 hour, and add 8 times the amount of solvent Heated and refluxed for 3 extractions, each time for 1.5 hours, filtered, and the filtrates were combined. The above filtrate was concentrated under reduced pressure at 45°C to obtain extract, suspended in water to 0.8-1.2g raw medicinal materials / ml, enriched by AB-8 macroporous adsorption resin, eluted with water, 30% ethanol, and 80% ethanol in sequence, Obtain each elution position, mainly collect 30% ethanol water elution position and 80% ethanol water elution position, then 30% ethanol water eluate is purified by polyamide column chromatography to obtain total monoterpene compound (total content greater than 90 %). Recover the solvent from each eluted part under reduced pressure at 45°C to an appropriate concent...

Embodiment 2

[0036] Preparation of raw materials and preparations:

[0037] According to the method in Example 1, the eluted part of 30% ethanol was purified by polyamide column chromatography to obtain total monoterpenoids with a total content greater than 90% or the eluted part of 80% ethanol to assist in improving memory capsules Or the raw material component of the tablet is used as the raw material, or the 30% or 80% ethanol elution site obtained by other means or methods is used as the raw material to prepare the following preparations.

[0038] 1. Tablet Preparation

[0039] Prescription 1 (50 tablets), the component contains 30% ethanol, and the water eluate is purified by polyamide column chromatography to obtain total monoterpenoids or 80% ethanol elution site to assist in improving memory. The raw material component is 5g, lactose is 5g, paste The essence is 8g, the microcrystalline cellulose is 5g, and the magnesium stearate is 0.2g. According to the operation method of conve...

Embodiment 3

[0047] The present invention starts from the memory loss caused by animal factors and senile pathological brain aging, and removes brain aging and vascular risk factors (hypertension, atherosclerosis, and transient cerebral ischemia, etc., which cause abnormal blood vessels or blood stasis in the brain). combined with brain hypoperfusion caused by multiple factors such as Aβ protein and senile pathological brain aging and memory loss, using intraperitoneal injection of galactose to promote aging and repeated ligation of bilateral neck Cerebral hypoperfusion induced by common artery and one-time injection into mouse ventricle (half the dose that can cause senile dementia or AD disease) Aβ amyloid production heterogeneity and multifactorial senile pathological brain aging memory loss (Heterogeneitys / Multi-fact ors'Old Age Pathological Brain Aging Memory Subside, H / MOAPBAMS) model. The heterogeneous and multifactorial senile pathological brain aging memory loss model rats were us...

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Abstract

The invention relates to an application of fructus gardeniae and ethanol eluting part memory-improving assisting capsules or tablets for preparing health-care foods for assisting in improving a memory function. The prepared fructus gardeniae and 30% ethanol eluting part memory-improving assisting capsules or tablets comprise the following raw material components of total monoterpenoid compounds of which the total content is greater than 90% and which is prepared through purifying 30% ethanol eluting parts of fructus gardeniae fruit total extracts through macroporous resins by a polyamide column chromatography method, wherein the total monoterpenoid compounds have the effect of assisting in improving the memory function on hypomnesis of senile physiological brain senescence caused by brain senescence, sleep disorders and A beta fibril formation and aggregation; and the prepared fructus gardeniae and 80% ethanol eluting part memory-improving assisting capsules or tablets comprise the components of 80% ethanol eluting parts of fructus gardeniae fruit total extracts, obtained through macroporous resins, wherein the 80% ethanol eluting parts have the effect of assisting in improving the memory function on hypomnesis of senile pathological brain senescence caused by brain senescence, brain hypoperfusion formed by blood vessel damage factors, and A beta fibril formation and aggregation.

Description

technical field [0001] The present invention relates to the application of gardenia 30% ethanol eluting parts to assist in improving memory capsules or tablets and gardenia 80% ethanol eluting parts to assist in improving memory capsules or tablets in the preparation of auxiliary memory function health food, which belongs to the preparation technology of traditional Chinese medicine field. Background technique [0002] 1. Investigation and analysis of the domestic situation and market demand of suitable people: According to statistics, the average life expectancy of Chinese people is 73 years old, and the natural life expectancy of people should be over 120 years old. In other words, everyone should have a natural aging period of 100 years, but the Chinese actually only use 50 years to die. That is to say, the aging speed of Chinese people is more than twice as fast as the law of natural science. This is the phenomenon of double-speed aging (tissue and organ aging, especia...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23P10/28A23P10/30A61K36/744A61K9/48A61K9/20A61P25/28
CPCA23V2002/00A61K9/1652A61K9/2054A61K36/744A61K2236/333A61K2236/53A61K2236/55A23V2200/322A23V2250/21A23V2300/14
Inventor 张忠立陈明人杨明左月明徐彭黄丽萍刘荣华史桂春朱根华
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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