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Injectable calcium sulfate hemihydrate/octacalcium phosphate/sodium hyaluronate sulphate composite artificial bone material and preparation method thereof

A technology of sodium hyaluronate and calcium sulfate hemihydrate, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of incomplete degradation, influence of new bone growth, long time of body retention, etc., and achieve operation Ease of application, good injectability, good hydrophilic effect

Active Publication Date: 2017-12-01
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But both materials have disadvantages. Injectable calcium sulfate artificial bone material degrades and absorbs too fast in the human body, faster than the formation of new bone, so it is not suitable for repairing large bone defects and long healing time Injectable calcium phosphate artificial bone, also known as injectable calcium phosphate bone cement, degrades slowly in the human body and stays in the body for too long, so it cannot meet the requirement of complete degradation after new bone formation, which affects The ingrowth of new bone limits its application

Method used

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  • Injectable calcium sulfate hemihydrate/octacalcium phosphate/sodium hyaluronate sulphate composite artificial bone material and preparation method thereof
  • Injectable calcium sulfate hemihydrate/octacalcium phosphate/sodium hyaluronate sulphate composite artificial bone material and preparation method thereof
  • Injectable calcium sulfate hemihydrate/octacalcium phosphate/sodium hyaluronate sulphate composite artificial bone material and preparation method thereof

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preparation example Construction

[0030] (1) Preparation of calcium sulfate hemihydrate powder: take analytically pure calcium sulfate dihydrate as raw material, adopt steam heating method to prepare calcium sulfate hemihydrate, at first, add a certain amount of calcium sulfate dihydrate in stainless steel container, then Add the corresponding amount of crystal-transforming agent solution that has been prepared, stir evenly, and react in a closed high-temperature and high-pressure reactor under the conditions of 0.15-0.2MPa pressure and 125-135°C for 4-6 hours, then take it out, and then put it into the temperature setting Dry it in an oven at 125-135°C, and finally take it out, grind it and sieve it to obtain calcium sulfate hemihydrate powder.

[0031] (2) Preparation of octacalcium phosphate powder: prepare a calcium acetate solution with a concentration of 0.04M and a sodium dihydrogen phosphate solution of 0.04M, and then slowly add the prepared calcium acetate solution to the sodium dihydrogen phosphate s...

Embodiment 1

[0037]An injectable calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulfate composite artificial bone material is prepared by the following method:

[0038] (1) Preparation of calcium sulfate hemihydrate / octacalcium phosphate composite powder: Mix 2 g of α-calcium sulfate hemihydrate (CSH) with a particle size of 1 to 200 μm and 2 g of octacalcium phosphate with a particle size of 1 to 200 μm, and add to Ultrasonic dispersion in absolute ethanol, followed by drying to make calcium sulfate hemihydrate / octacalcium phosphate composite powder;

[0039] (2) Preparation of sodium hyaluronate sulfate solidified solution: dissolve sodium hyaluronate sulfate with a particle size of 1 to 100 μm in deionized water, and stir magnetically to obtain a 1 wt% sodium hyaluronate sulfate solidified solution;

[0040] (3) Mix sodium hyaluronate sulfate solidified liquid with calcium sulfate hemihydrate / octacalcium phosphate composite powder at a ratio of 0.5ml / g for 0.5 to 2...

Embodiment 2

[0043] An injectable calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulfate composite artificial bone material is prepared by the following method:

[0044] (1) Preparation of calcium sulfate hemihydrate / octacalcium phosphate composite powder: mix 2 g of α-calcium sulfate hemihydrate (CSH) with a particle size of 1 to 300 μm and 1 g of octacalcium phosphate with a particle size of 1 to 200 μm, and add to Ultrasonic dispersion in absolute ethanol, followed by drying to make calcium sulfate hemihydrate / octacalcium phosphate composite powder;

[0045] (2) Preparation of sodium hyaluronate sulfate solidified solution: dissolve sodium hyaluronate sulfate with a particle size of 1 to 100 μm in deionized water, and stir magnetically to obtain a 1 wt% sodium hyaluronate sulfate solidified solution;

[0046] (3) Mix the sodium hyaluronate sulfate solidified solution with calcium sulfate hemihydrate / octacalcium phosphate composite powder at a ratio of 0.4ml / g for 0...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to an injectable calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulphate composite artificial bone material and a preparation method thereof. The artificial bone material is obtained by blending sodium hyaluronate sulphate solidification liquor with calcium sulfate hemihydrate / octacalcium phosphate composite powder, wherein the mass ratio of calcium sulfate hemihydrate, octacalcium phosphate to sodium hyaluronate sulphate is 1:(0.01-0.5):(0.01-0.5). The injectable calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulphate composite artificial bone material and the preparation method thereof have the advantages that the preparation process is simple and easy to operate; the obtained calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulphate composite artificial bone material has good injection performance; components in the composite artificial bone material are controllable; conventional inorganic bone materials are composited with organic materials, and accordingly, high strength, biological compatibility, osteogenesis performance and degradation controllability are achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an injectable calcium sulfate hemihydrate / octacalcium phosphate / sodium hyaluronate sulfate composite artificial bone material and a preparation method thereof. Background technique [0002] Bone defects have always been a difficult problem in orthopedic medicine. In recent years, with the development of minimally invasive surgery, injectable artificial bone materials have attracted more and more attention from researchers from various countries, and have become a research hotspot in biomedical materials today. Injectable calcium sulfate artificial bone material and calcium phosphate artificial bone material are the most common calcium-phosphate inorganic system materials. The materials are easy to operate and have good biocompatibility. When injected into bone defects, they can be cured in situ and adapt to Bone defect and shaping. But both materials have disadvantages. Inje...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/58
CPCA61L27/446A61L27/58A61L2400/06A61L2430/02C08L5/08
Inventor 樊李红朱晨闵莲柳梦
Owner WUHAN UNIV OF TECH
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