Oral emulsion rich in [alpha]-linolenic acid and preparation method of oral emulsion

A technology of linolenic acid and emulsion, applied in the field of medicine, can solve the problems of poor compliance of injection patients, unfavorable daily long-term use, and undetermined safety evaluation of injections, etc., to improve bioavailability, significant social value and economic value, and curative effect significant effect

Active Publication Date: 2017-12-08
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the safety evaluation of injections has yet to be determined, and patients who often use injections have poor compliance, which is not conducive to daily or long-term use

Method used

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  • Oral emulsion rich in [alpha]-linolenic acid and preparation method of oral emulsion
  • Oral emulsion rich in [alpha]-linolenic acid and preparation method of oral emulsion
  • Oral emulsion rich in [alpha]-linolenic acid and preparation method of oral emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] An oral emulsion rich in α-linolenic acid is made of the following components according to weight percentage: 15% of vegetable oil containing α-linolenic acid, 25% of emulsifier (lecithin), auxiliary agent (1,2-propylene glycol ) 5%, antioxidant (vitamin E) 0.3%, flavoring agent (aspartame) 0.1%, and the balance is purified water; the vegetable oil containing α-linolenic acid is extracted by the following components in parts by weight Ingredients: 25 parts of eucommia seeds, 15 parts of perilla seeds, 15 parts of kiwi seeds, 17 parts of peony seeds, 16 parts of flax seeds, and 12 parts of Zanthoxylum bungeanum seeds.

[0041] The preparation method of the above-mentioned oral emulsion rich in α-linolenic acid comprises the following steps:

[0042] (1) take each raw material by weight ratio;

[0043] (2) Screen Eucommia seeds, perilla seeds, kiwi seeds, peony seeds, flax seeds and Zanthoxylum bungeanum seeds, remove impurities, pulverize, pass through a 40-mesh sieve, ...

Embodiment 2

[0047] An oral emulsion rich in α-linolenic acid is made of the following components according to weight percentage: 10% of vegetable oil containing α-linolenic acid, emulsifier (soya lecithin and Tween-80 are mixed according to the mass ratio of 2:1 ) 20%, auxiliary agent (glycerol) 10%, antioxidant (vitamin E) 0.3%, corrective agent (aspartame) 0.1%, and the balance is purified water; the vegetable oil containing α-linolenic acid is made of The following components are extracted in parts by weight: 20 parts of eucommia seeds, 10 parts of perilla seeds, 10 parts of kiwifruit seeds, 12 parts of peony seeds, 10 parts of flax seeds and 7 parts of pepper seeds.

[0048] The preparation method of the above-mentioned oral emulsion rich in α-linolenic acid comprises the following steps:

[0049] (1) take each raw material by weight ratio;

[0050] (2) Screen Eucommia seeds, perilla seeds, kiwi seeds, peony seeds, flax seeds and Zanthoxylum bungeanum seeds, remove impurities, pulver...

Embodiment 3

[0054] An oral emulsion rich in α-linolenic acid is made of the following components according to weight percentage: 5% vegetable oil containing α-linolenic acid, emulsifier (molecular distillation monoglyceride and Tween-80 according to the mass ratio of 3 : 1 mixed) 1%, auxiliary agent (n-butanol) 0.1%, antioxidant (sodium sulfite) 0.01%, flavoring agent (aspartame) 0.1%, and the balance is purified water; The sour vegetable oil is extracted from the following components in parts by weight: 23 parts of eucommia seeds, 12 parts of perilla seeds, 12 parts of kiwifruit seeds, 15 parts of peony seeds, 12 parts of flax seeds and 10 parts of pepper seeds.

[0055] The preparation method of the above-mentioned oral emulsion rich in α-linolenic acid comprises the following steps:

[0056] (1) take each raw material by weight ratio;

[0057] (2) Screen Eucommia seeds, perilla seeds, kiwi seeds, peony seeds, flax seeds and Zanthoxylum bungeanum seeds, remove impurities, pulverize, pa...

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Abstract

The invention discloses an oral emulsion rich in [alpha]-linolenic acid. The oral emulsion is prepared from the following components in percentage by weight: 1-25% of plant oil containing the [alpha]-linolenic acid, 1-25% of an emulsifier, 0.1-20% of adjuvants, 0.001-5% of an antioxidant, 0-1.5% of flavoring agent and the balance of purified water; and the plant oil containing the [alpha]-linolenic acid is extracted from the following components in parts by weight: 20-25 parts of eucommia ulmoides oliver seeds, 10-15 parts of perilla seeds, 10-15 parts of kiwi fruit seeds, 12-17 parts of peony seeds, 10-16 parts of linseed and 7-12 parts of Chinese prickly ash seeds. The invention also discloses a preparation method of the oral emulsion rich in the [alpha]-linolenic acid. The oral emulsion containing the [alpha]-linolenic acid prepared by the invention is stable in ingredient, high in bioavailability, free from toxic and side effects, obvious in curative effect, broad in application to indications and obvious in social and economic values, and bad smell and taste of the oil can be masked.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral emulsion rich in α-linolenic acid and a preparation method thereof. Background technique [0002] Alpha-linolenic acid is an essential fatty acid for the human body. α-linolenic acid is a polyunsaturated fatty acid with three double bonds (C 18 h 30 o 2 ), is an omega-3 essential fatty acid; the physiological effects of α-linolenic acid: enhance intelligence, improve memory, protect eyesight, improve sleep, inhibit thrombotic diseases, prevent myocardial infarction and cerebral infarction, reduce blood fat, lower blood pressure, inhibit Hemorrhagic stroke, prevention of allergies. Studies have shown that the lack of α-linolenic acid will lead to retardation of brain and retinal development in children, inattention, unbalanced nutrition, and ineffective absorption, which will directly lead to: mental retardation, uncoordinated movements, weak vision, ADHD,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K9/107A61P9/12A61P3/06A61P25/28A61P27/02A61P37/08A61P35/00A61P3/04A61P9/10
CPCA61K9/0053A61K9/107A61K36/185A61K36/46A61K36/535A61K36/55A61K36/65A61K36/71A61K36/758A61K2236/37A61K2300/00
Inventor 李钦王一飞丁艳霞
Owner HENAN UNIVERSITY
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