Application of thyroxine receptor analogues and salts or predrugs thereof to preparation of pulmonary disease treating and/or preventing drugs

A thyroxine and lung disease technology, applied in the field of thyroxine receptor analogs and their pharmaceutically acceptable salts or prodrugs, to achieve the effects of changing the environment of canceration, facilitating removal, and preventing and treating lung diseases

Inactive Publication Date: 2017-12-15
深圳市润佳通科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there has been no report on the use of thyroxine receptor analogs and their pharmaceutically acceptable salts or prodrugs for the treatment and / or prevention of lung diseases

Method used

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  • Application of thyroxine receptor analogues and salts or predrugs thereof to preparation of pulmonary disease treating and/or preventing drugs
  • Application of thyroxine receptor analogues and salts or predrugs thereof to preparation of pulmonary disease treating and/or preventing drugs
  • Application of thyroxine receptor analogues and salts or predrugs thereof to preparation of pulmonary disease treating and/or preventing drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Preparation of thyroxine receptor analogs:

[0077] Take GC-1, dissolve it in dimethyl sulfoxide, and then dilute it with normal saline to make a liquid for injection and gavage. The working volume is 200 microliters.

[0078] The specific implementation of the present invention will be described below in conjunction with the accompanying drawings.

[0079] figure 1 Histogram of hydroxyproline content (A) and gene expression analysis graph (B, C, D) of mice after intraperitoneal injection of GC-1;

[0080] figure 2 Mason's trichrome staining histochemical analysis diagram of mouse lung tissue after intraperitoneal injection of GC-1;

[0081] figure 1 and figure 2 The therapeutic effect of intraperitoneal injection of GC-1 on pulmonary fibrosis in mice is shown. C57BL / 6 mice were induced by bleomycin (1.5U / kg) for 10 days, and then injected with the thyroxine receptor analogue GC-1 (indicated by BLM+GC-1 in the figure) after the appearance of fibrosis , once a ...

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Abstract

The invention provides a novel application of thyroxine receptor analogues and pharmaceutically acceptable salts or predrugs thereof which are used for treating and / or preventing pulmonary diseases. The thyroxine receptor analogues and the pharmaceutically acceptable salts or predrugs thereof can effectively protect alveolar epithelial cells, adjust synthesis, storage and distribution of surface proteins of the alveolar epithelial cells, promote maturation, differentiation and integrity of the alveolar epithelial cells, are beneficial to elimination of hydrops in the lung, promote recovery of damaged mitochondria in the alveolar epithelial cells and enhance bio-synthesis of the mitochondria, so that repair of damaged lung tissue is facilitated, pulmonary fibrosis is stopped and reversed, immunoreaction is regulated, a cancerization environment is changed, pulmonary diseases are prevented and treated, pulmonary functions such as gas exchange and the like are improved, and the treatment effect is realized.

Description

technical field [0001] The present invention relates to a new use of thyroid hormone receptor analogs and pharmaceutically acceptable salts or prodrugs thereof, in particular to a thyroid hormone receptor analog and pharmaceutically acceptable salts or prodrugs thereof in the preparation of therapeutic and / or in medicines for the prevention of lung disease. Background technique [0002] Microbial populations in the air in the living environment, indoor and outdoor air pollution, including smoking, can directly cause lung tissue damage in people susceptible to lung diseases, cause lesions, and can cause inflammation, acute lung injury, pulmonary fibrosis, lung cancer, etc. disease. What is even more concerning is that with the rapid development of my country's economy, environmental pollution is becoming more and more serious, especially the current severe smog situation. Such a bad air environment is bound to threaten the lungs of the general public, and the number of resp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/192A61K31/4418A61K31/496A61P11/00A61P35/00
CPCA61K45/06A61K31/192A61K31/4418A61K31/496A61K2300/00
Inventor 余国营
Owner 深圳市润佳通科技有限公司
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