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Micromolecular hyaluronic acid and preparation method thereof

A technology of small molecule hyaluronic acid and deionized water, applied in the field of skin care products, can solve the problems of large molecular weight of hyaluronic acid and unfavorable skin absorption, and achieve the effect that is beneficial to health

Inactive Publication Date: 2017-12-19
广州中涵药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing hyaluronic acid has a large molecular weight, which is not conducive to skin absorption

Method used

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  • Micromolecular hyaluronic acid and preparation method thereof
  • Micromolecular hyaluronic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The components of this example are as follows: 5% glycerin, 10% propylene glycol, 10% butylene glycol, 1% peel extract, 1% hydrolyzed sodium hyaluronate, 5% glycerol glucoside, 5% glucosaminoglycan , 10% hydrolyzed collagen, 1% carbomer, 1% triethanolamine, 2% bis(hydroxymethyl) imidazolidinyl urea, 1% iodopropynyl butyl carbamate, and the balance is deionized water.

Embodiment 2

[0024] The components of this example are as follows: 2% Glycerin, 3% Propylene Glycol, 4% Butylene Glycol, 0.5% Peel Extract, 0.3% Hydrolyzed Sodium Hyaluronate, 2% Glycerol Glucoside, 3% Glucosaminoglycan , 6% hydrolyzed collagen, 0.3% carbomer, 0.4% triethanolamine, 0.6% bis(hydroxymethyl) imidazolidinyl urea, 0.5% iodopropynyl butyl carbamate, and the balance is deionized water.

Embodiment 3

[0026] The components of this example are as follows: 0.1% glycerin, 0.1% propylene glycol, 0.1% butylene glycol, 0.1% peel extract, 0.1% hydrolyzed sodium hyaluronate, 0.1% glycerol glucoside, 0.1% glucosaminoglycan , 0.1% hydrolyzed collagen, 0.1% carbomer, 0.1% triethanolamine, 0.1% bis(hydroxymethyl) imidazolidinyl urea, 0.1% iodopropynyl butyl carbamate, and the balance is deionized water.

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Abstract

The invention discloses a small-molecule hyaluronic acid and a preparation method thereof, wherein the small-molecule hyaluronic acid comprises the following components in mass percent: 0.1-5% glycerin, 0.1-10% propylene glycol, 0.1-10% butanediol, 0.1% ~1% fruit peel extract, 0.1~1% hydrolyzed sodium hyaluronate, 0.1~5% glycerol glucoside, 0.1~5% glucosaminoglycan, 0.1~10% hydrolyzed collagen, 0.1~1% carbomer , 0.1-1% triethanolamine, 0.1-2% bis(hydroxymethyl) imidazolidinyl urea, 0.1-1% iodopropynyl butyl carbamate, and the balance is deionized water. The present invention also provides a preparation method of small molecule hyaluronic acid, comprising 1) preparing citrus peel extract for standby use, 2) batching, 3) raising the temperature to prepare stock solution, 4) preparing crude product, and 5) improving quality. The hyaluronic acid prepared by the invention has a molecular weight of 500,000 to 800,000 daltons, which is beneficial to the skin's absorption, and simultaneously adopts fruit peel extracts and easy-absorbed organic matter, which is beneficial to the health of the skin.

Description

technical field [0001] The invention belongs to the technical field of skin care products, and in particular relates to a small molecule hyaluronic acid and a preparation method. Background technique [0002] Hyaluronic acid is a natural biomolecule widely present in the skin and other tissues. It has an excellent moisturizing effect and is internationally known as the ideal natural moisturizing factor (Natural MolsturlZlng Factor, NMF). It is the best moisturizing substance found in nature and can be used in cosmetics. Hyaluronic acid acts on the skin surface, macromolecular hyaluronic acid can form a breathable film on the skin surface, small molecular hyaluronic acid can penetrate into the dermis, slightly dilate capillaries, increase blood circulation, improve intermediate metabolism, and promote skin nutrient absorption. The anti-wrinkle function can increase skin elasticity and delay skin aging. Hyaluronic acid can also promote the proliferation and differentiation o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/34A61K8/41A61K8/49A61K8/60A61K8/65A61K8/73A61K8/44A61K8/81A61Q19/00
CPCA61K8/65A61K8/345A61K8/41A61K8/44A61K8/4946A61K8/602A61K8/73A61K8/735A61K8/8147A61K8/97A61Q19/00
Inventor 陈弟三
Owner 广州中涵药业有限公司
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