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Facial repair anti-inflammatory composition and application thereof

An anti-inflammatory composition and facial repair technology, applied in the directions of anti-inflammatory agents, drug combinations, cosmetic preparations, etc., to achieve the effects of high embedding efficiency, increased permeability, and high equipment requirements

Active Publication Date: 2017-12-29
广州昕生医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a facial repairing anti-inflammatory composition for problems such as facial skin dryness, skin aging, pigmentation and inflammation

Method used

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  • Facial repair anti-inflammatory composition and application thereof
  • Facial repair anti-inflammatory composition and application thereof
  • Facial repair anti-inflammatory composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056] The preparation method of the SIS used in the specific embodiment of the present invention comprises the following steps:

[0057] (1) After the submucosa tissue of porcine small intestine was decellularized, the decellularized tissue matrix was obtained;

[0058] (2) Take 100 g (wet weight) of the acellular tissue matrix described in step (1) and pulverize it, add it to 100 mL of 0.01 mol / L HCl solution containing 100 mg of pepsin (2000-2300 U / mg), and heat it at room temperature (25° C.) Stirring for 48 hours, the pH of the viscous solution obtained by pepsin digestion is 3.0-4.0, and the pH is adjusted to 7.4 with NaOH solution to obtain the decellularized tissue matrix degradation solution;

[0059] (3) Mix the acellular tissue matrix degradation liquid described in step (2) with 4 g of sodium alginate evenly, pour it into a mold, freeze-dry, and pulverize to obtain the acellular tissue matrix composite material.

[0060] Examples 1-3 are facial repairing and anti-...

Embodiment 4

[0069] The preparation method of the SIS freeze-dried powder of embodiment 4, comprises the steps:

[0070] (1) Irradiation sterilization: SIS, active peptide, arbutin, trehalose, vitamin E, allantoin, glycerin (A-1 and A-2), water (B-1 and B-2), Lecithin, hydrogenated lecithin, cholesterol and ethanol are sterilized by irradiation;

[0071] (2) Assemble liposomes: get the sterilized lecithin obtained in step (1), sterilized hydrogenated lecithin and sterilized cholesterol and mix evenly to obtain assembled liposomes, then add assembled liposomes to glycerol In the mixed solution of (A-2) and ethanol, stir to disperse, dilute with water (B-2), obtain the assembly liposome solution;

[0072] (3) Add the sterilized active peptide, sterilized arbutin, sterilized trehalose, sterilized vitamin E and sterilized allantoin obtained in step (1) to a part of water (A-1) Dissolve in medium, mix evenly, obtain mixed solution;

[0073] (4) Slowly add the assembled liposomes described in...

Embodiment 8

[0082] Embodiment 8 Restoration Efficacy

[0083] Test purpose: the moisturizing water of embodiment 1-3 and comparative example 1-2, the face repairing anti-inflammation mask of embodiment 5 are carried out the verification of repairing effect, and repairing effect measurement includes diluting wrinkle, emollient effect, diluting pigmentation , Improvement of skin pores, etc.

[0084] testing object:

[0085] Subjects included in this clinical study and subjects excluded from this clinical study were selected according to the following criteria:

[0086] 1. Age 25 to 60

[0087] 2. Symptoms of dryness, skin aging, pigmentation, and more wrinkles on the facial skin

[0088] Exclusion criteria:

[0089] 1. People who are allergic to protein should use it with caution

[0090] 2. No obvious trauma to the skin

[0091] All volunteers were questioned and had a physical examination of the facial skin, and only those subjects who met the required criteria were included in this...

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Abstract

The invention relates to a facial repair anti-inflammatory composition and application thereof. The facial repair anti-inflammatory composition comprises SIS, active peptide, arbutin, trehalose, vitamin E and allantoin, wherein the SIS is an acellular tissue matrix composite material, and the acellular tissue matrix composite material is obtained by pulverizing an acellular tissue, degrading with digestive liquid or a lysate, then mixing with a polyelectrolyte solution, freezing, drying and pulverizing. When being used for the repair and the anti-inflammation of facial skin, the facial repair anti-inflammatory composition can achieve the efficacies of effectively promoting the metabolism, the growth, the proliferation and the differentiation of facial cells, scavenging free radicals, reducing pigment accumulation, resisting the radiation, moisturizing, resisting the inflammation and the like, thereby effectively solving the skin problems such as skin dryness, skin aging, pigmentation, irritant dermatitis, daylight dermatitis, hormone dependent dermatitis and the like.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a face repairing anti-inflammatory composition and its application. Background technique [0002] The skin is the tissue covering the muscles on the surface of the body and is the largest organ of the human body. As a barrier between the human body and the outside world, the skin is mainly composed of three layers: epidermis, dermis and subcutaneous tissue, and plays an important protective role in human health. The skin barrier is composed of sebum membrane, stratum corneum keratin, lipids, etc. It can resist external harmful substances, irritants, ultraviolet rays, etc., and has moisturizing, regulating and anti-inflammatory effects. However, due to the indiscriminate use of cosmetics and cosmetology, most people have skin barrier damage and skin sensitivity problems, resulting in dry skin, skin aging, pigmentation, and even irritant dermatitis, solar dermatitis, and hormone...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/67A61K8/64A61K8/60A61K8/14A61K8/49A61Q19/00A61Q19/02A61Q19/08A61P29/00
CPCA61K8/14A61K8/4946A61K8/60A61K8/602A61K8/64A61K8/645A61K8/678A61K8/981A61K2800/56A61Q19/00A61Q19/004A61Q19/02A61Q19/08
Inventor 杨伟红程飚耿梦梦王祥林晏兰刘江辉
Owner 广州昕生医学材料有限公司
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