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Stable fenofibric acid tablet and preparation method thereof

A fenofibric acid and stable technology, applied in the field of medicine, can solve the problems of complex preparation process and high cost, and achieve the effects of simplified preparation process, rapid disintegration and simple process

Inactive Publication Date: 2018-01-09
赵剑锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problems of complex preparation process and high cost of the existing fenofibric acid preparation method, to provide a stable fenofibric acid tablet and its preparation method

Method used

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  • Stable fenofibric acid tablet and preparation method thereof
  • Stable fenofibric acid tablet and preparation method thereof
  • Stable fenofibric acid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of stable fenofibric acid tablet in the present embodiment is made up of the component of following weight ratio:

[0025] components

weight ratio

Raw material: fenofibric acid

1

Filler: microcrystalline cellulose

6.25

Disintegrant: Crospovidone

0.43

Binder: Copovidone

0.4

Lubricant: magnesium stearate

0.07

[0026] The preparation method of fenofibric acid tablet in the above-mentioned embodiment, described method is powder direct compression technology, specifically is made up of the following steps:

[0027] 1) Pass the fenofibric acid raw material and auxiliary materials through a 60-200-mesh sieve for later use;

[0028] 2) Weigh the material according to the weight ratio of fenofibric acid, microcrystalline cellulose, crospovidone, copovidone and magnesium stearate to 1:6.25:0.43:0.4:0.07; Norbenic acid, microcrystalline cellulose, crospovidone and copovidone are mixed evenly;

[0029] 3)...

Embodiment 2

[0031] A kind of stable fenofibric acid tablet in the present embodiment is made up of the component of following weight ratio:

[0032] components

Proportion

Raw material: fenofibric acid

1

Filler: microcrystalline cellulose

4

Disintegrant: Crospovidone

2

Binder: Copovidone

0.1

Lubricant: magnesium stearate

0.01

[0033] The preparation method of fenofibric acid tablet in the above-mentioned embodiment, described method is powder direct compression technology, specifically is made up of the following steps:

[0034] 1) Pass the fenofibric acid raw material and auxiliary materials through a 60-200-mesh sieve for later use;

[0035] 2) Weigh the material according to the weight ratio of fenofibric acid, microcrystalline cellulose, crospovidone, copovidone and magnesium stearate at 1:4:2:0.1:0.01; Norbenic acid, microcrystalline cellulose, crospovidone and copovidone are mixed evenly;

[0036] 3) Adding magnes...

Embodiment 3

[0038] A kind of stable fenofibric acid tablet in the present embodiment is made up of the component of following weight ratio:

[0039]

[0040]

[0041] The preparation method of fenofibric acid tablet in the above-mentioned embodiment, described method is powder direct compression technology, specifically is made up of the following steps:

[0042] 1) Pass the fenofibric acid raw material and auxiliary materials through a 60-200-mesh sieve for later use;

[0043] 2) Weigh the material according to the weight ratio of fenofibric acid, microcrystalline cellulose, crospovidone, copovidone and magnesium stearate at 1:7:0.1:1:0.1; Norbenic acid, microcrystalline cellulose, crospovidone and copovidone are mixed evenly;

[0044] 3) Adding magnesium stearate to the mixture obtained in step 2), mixing evenly, and pressing into tablets to obtain the fenofibric acid tablets, the hardness of the obtained fenofibric acid tablets is 5-9kgf.

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Abstract

The invention relates to a stable fenofibric acid tablet and a preparation method thereof. The preparation method aims to solve the technical problems that the conventional preparation method of fenofibric acid is complex in technology and high in cost. The stable fenofibric acid tablet adopts the technical scheme that the stable fenofibric acid tablet comprises the following components with the weight ratio: fenofibric acid, a filling age, a disintegrating agent, an adhesive and a lubricant with the weight ratio being 1:(4-7):(0.1-2):(0.1-1):(0.01-0.1). The preparation method adopts a powderdirect tabletting technology, the preparation process is simple, the energy consumption and material consumption are reduced, the production period is shortened, and the production cost is reduced; auxiliary materials of the fenofibric acid tablet are screened and matched, the number of varieties of the auxiliary materials is reduced while the changeless bioavailability is guaranteed, the preparation technology is simplified, and the fenofibric acid tablet which is good in stability, rapid in disintegration and dissolution and simple in technology is formed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a stable fenofibric acid tablet and a preparation method thereof. Background technique [0002] Fenofibric acid, a peroxisome proliferator receptor alpha (PPAR) activator, is the first and so far the only fenofibric acid drug approved for use in combination with statins. Fenofibric acid combined treatment significantly improved HDL and triglyceride levels compared with statins alone, and significantly improved LDL compared with this product alone. For some patients, clinical treatment guidelines recommend the combination of fenofibric acid and statins to further improve blood lipids. [0003] Fenofibric Acid Tablets is a tablet of fenofibric acid (Fenofibric Acid), which is a blood lipid regulating drug derived from clofibric acid, which inhibits the formation of very low-density lipoprotein and triglyceride and at the same time Increase its catabolism, reduce blood low-density lipoprot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61P3/06
Inventor 赵剑锋
Owner 赵剑锋
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