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Active compound for improving p53 tumor inhibiting gene expression in targeted way

A tumor suppressor gene, complex technology, applied in the direction of inorganic active ingredients, organic active ingredients, drug combinations, etc., can solve the problem of less p53 targeted therapy

Inactive Publication Date: 2018-01-12
深圳靶向基因技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are few drug studies on p53-targeted therapy, and there is no effective, multi-site targeted intervention drug for p53 gene

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] The preparation method of the active complex in the present invention is to mix and dissolve anthocyanin extract and metal ions in water to form a chelate. For the concentration of anthocyanins and metal ions in the preparation process of the active complex of the present invention, refer to the concentrations of anthocyanins and metal ions in the active complex solution above, and will not be repeated here.

[0036] In the present invention, the protein expressed for the p53 gene is mainly distributed in the nucleoplasm, can specifically bind to DNA, and its activity is regulated by post-translational modifications such as phosphorylation, acetylation, methylation, and ubiquitination. Glycosides eliminate harmful free radicals, various mineral element ions and vitamin cofactors Cofactor(s) involved in enzyme-catalyzed reactions, P53 target matrix metalloproteinase MMP, hypoxia-inducible factor HIF, MDM2 zinc finger protein (structure easily affected by heavy metal ions ...

Embodiment 1

[0047] A kind of active compound solution targeting to improve the expression of p53 tumor suppressor gene, the composition and content of the active compound are shown in Table 1.

[0048] Table 1 Composition of the active complex targeted to increase the expression of p53 tumor suppressor gene

[0049] Element

element symbol

per 100ml

Ion concentration (mg / ml)

Blueberry Anthocyanins

300mg

3

iron

Fe

5mg

0.05

calcium

Ca

3mg

0.03

zinc

Zn

2mg

0.02

selenium

Se

10ug

0.0001

magnesium

Mg

12mg

0.12

manganese

mn

45ug

0.00045

molybdenum

Mo

10ug

0.0001

Potassium

K

20mg

0.2

rubidium

Rb

20ug

0.0002

lithium

Li

20ug

0.0002

[0050] Among them, blueberry anthocyanin is entrusted to Daxinganling Lingebei Cold Zone Biotechnology Co., Ltd. to process, and the blueberry anthocy...

Embodiment 2

[0053] A kind of active complex solution targeting to improve the expression of p53 tumor suppressor gene, the composition and content of the active complex are shown in Table 2.

[0054] Table 2 The composition of the active complex targeted to increase the expression of p53 tumor suppressor gene

[0055] Element

element symbol

per 100ml

Ion concentration (mg / ml)

Blueberry Anthocyanins

1g

10

iron

Fe

10mg

0.1

calcium

Ca

30mg

0.3

zinc

Zn

4mg

0.04

selenium

Se

100ug

0.001

magnesium

Mg

25mg

0.25

manganese

mn

50ug

0.0005

molybdenum

Mo

20ug

0.0002

Potassium

K

40mg

0.4

rubidium

Rb

20ug

0.0002

lithium

Li

20ug

0.0002

[0056] Among them, blueberry anthocyanin is entrusted to Daxinganling Lingebei Cold Zone Biotechnology Co., Ltd. to process, and the blueberry anthocyan...

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Abstract

The invention relates to an active compound for improving the p53 tumor inhibiting gene expression in a targeted way. The active compound is obtained from the raw materials including the following ingredients through chelation: cyanin and metal ions, wherein the metal ions include Fe<2+>, Ca<2+>, Zn<2+>, Se<2+>, Mg<2+>, Mn<2+>, Mo<2+>, K<+>, Rb<+> and Li<+>. By starting from eliminating harmful free radicals by the cyanin, acting various mineral element ions and vitamin accessory factors (cofacter(s)) participating the enzyme catalysis reaction, and P53 onto target matrix metalloproteinases MMP and regulating and controlling hypoxia-inducible factors HIF, MDM2 zinc finger protein (the structure can be easily tampered by heavy metal ions), miRNA nickase Dicer, the P53 gene is subjected to encircle target regulation to reach the goal of controlling the cancer cell development and inducing the cancer cell senescence and death.

Description

technical field [0001] The invention relates to the technical field of targeted tumor suppressor drugs, in particular to an active compound targeting to increase the expression of p53 tumor suppressor gene. Background technique [0002] Cancer is a genetic disease, which is a multi-stage long-term evolution process in which various pre-oncogenes are activated and tumor suppressor genes are inactivated in human cells under the action of external environmental factors. Before the maturity of precision medical technology, the main treatment methods for cancer were radiotherapy, chemotherapy and surgery. Although medical scientists continue to improve these three treatment methods, many cancer patients are still difficult to be cured. One of the important reasons is that the microenvironment of gene mutation has not been fundamentally intervened. With the maturity of gene sequencing technology, especially the control of enzyme activity and the clarification of DNA biochemical m...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K33/06A61K33/30A61K33/04A61K33/32A61K33/00A61P35/00A61K31/7048
Inventor 乌林奇
Owner 深圳靶向基因技术有限公司
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