Unlock instant, AI-driven research and patent intelligence for your innovation.

Production method of 2-aminophenylacetophenone hydrochloride

A technology of methylacetophenone hydrochloride and its production method, which is applied in the field of organic synthesis, can solve problems such as large environmental pollution, and achieve the effects of reducing pollution, simple and easy-to-control production conditions, and increasing revenue

Inactive Publication Date: 2018-02-02
JINGCHU UNIV OF TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Comparing the above two production methods, the second production method is better, the second method has simple process and low cost, but a large amount of ammonium chloride and aluminum chloride aqueous solution are produced by-products, which cause greater environmental pollution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Production method of 2-aminophenylacetophenone hydrochloride
  • Production method of 2-aminophenylacetophenone hydrochloride
  • Production method of 2-aminophenylacetophenone hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Production of 2-chloro-p-methylacetophenone toluene:

[0027] at 10m 3 Put 4500L of toluene into the glass-lined reaction kettle, under the protection of nitrogen, stir and cool down to 10°C, control the temperature in the reaction kettle below 30°C, first stir a bag and add 590kg of anhydrous aluminum trichloride, and then control the reaction kettle When the temperature is below 40°C, 500kg of chloroacetyl chloride is added dropwise under stirring, and the temperature is raised to 50°C after the dropwise addition, and the stirring reaction is continued for 2 hours, then the temperature is raised to reflux, and reflux is continued for 4 hours. After the reflux is completed, 250kg of 32wt% hydrochloric acid and 340kg of Water, heat up to 50°C, stop nitrogen protection after hydrolysis for 1 hour, then stand for stratification for 1 hour, separate, the water layer is aluminum chloride with a concentration of about 50wt%, put it into a storage tank for recycling, and s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a production method of 2-aminophenylacetophenone hydrochloride. The production method includes the steps of 1), production of 2-chlorinated p-methylacetophenone toluene; 2),production of 2-chlorinated p-methylacetophenone hexamethylenetetramine ammonium salt; 3), production of the 2-aminophenylacetophenone hydrochloride. The production method is relatively simple, easyin control of production conditions, convenient in operation and low in production cost.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a production method of 2-amino-p-methylacetophenone hydrochloride. Background technique [0002] 2-Amino-p-methylacetophenone hydrochloride is an important intermediate of pharmaceuticals and pesticides. There are mainly the following production methods: [0003] 1. First adopt bromination of p-methylacetophenone to obtain 2-bromo-p-methylacetophenone (see JP61152637, CN101723912, CN101709056), then use 2-bromo-p-methylacetophenone with sodium diformamide and sodium azide ( NaN 3 ) reaction to synthesize 2-amino-p-methylacetophenone (see US20050113283, US2003062392), the second step of this route needs hydrogenation reduction, and the operation is more complicated; [0004] 2. Acylation with toluene and chloroacetyl chloride to obtain 2-chloro-p-tolyl ketone (see WO2008125014, CN101928253); Ammonolysis and then hydrazinolysis give 2-amino-p-methylacetophe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C221/00C07C225/06
CPCC07C221/00C07C45/68C07C225/06C07C49/80
Inventor 胡莉萍吴瑞胡冠丰
Owner JINGCHU UNIV OF TECH