Interstitial lung disease-resistant medicine based on centipede extract and preparation method thereof

Abstract

A method for preparing an interstitial lung disease-resistant medicine based on centipede extract includes the steps of freezing fresh centipede larvae and pulverizing the larvae into powder, adding aphosphate buffer and proteinase K aqueous solution for processing; boiling in boiling water and cooling on ice; after uniform shaking, performing centrifugation, and taking supernatant; adding anhydrous ethanol and then performing centrifugation and taking upper layer protein fluid; taking licorice, loquat and tangerine peel, performing steam distillation to obtain dregs, volatile oil and aqueoussolution; mixing the dregs and stir-fried apricot kernels and the like, adding water for decoction, and performing filtration to obtain filtrate; concentrating the filtrate into clear paste, adding the upper layer protein fluid and the volatile oil into the clear paste, performing drying under reduced pressure after uniform mixing, performing smashing, and then performing sieving through a 50-100-mesh sieve to obtain dry extract powder; and after uniform mixing with dextrin, performing granulation and granule tidying to obtain dry granules. The prepared medicine can relieve cough and dyspneain a patient, improve lung functions and have obvious advantages in the treatment of interstitial lung diseases.

Description

technical field [0001] The invention relates to a Chinese patent medicine, in particular to a preparation method of a centipede extract-based anti-interstitial lung disease medicine, and belongs to the field of medicinal chemistry. Background technique [0002] The incidence of interstitial lung disease is increasing year by year, and there are more than 200 types of classification. Nowadays, research on the pathogenesis of interstitial lung disease from the perspective of cytomolecular science has made some progress, but it is not completely thorough. In terms of treatment, traditional hormone therapy can relieve some symptoms and control the disease, but the long-term clinical efficacy is not very satisfactory and has certain limitations. In many years of clinical experience, the application of traditional Chinese medicine in the treatment of interstitial lung disease often achieves good therapeutic effects. There is no name for interstitial lung disease in ancient Chine...

AI Technical Summary

Problems solved by technology

[0004] However, there are very few reports on the treatment of interstitial lung disease by centipedes in domestic and foreign literature, and there is still a lack of research on the cellular and molecular mechanisms of centipedes in treating this disease.

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