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A low-molecular-weight chitosan@silver nanoparticle composite film and its preparation method and application

A low-molecular-weight chitosan and silver nanoparticle technology, which is applied in the field of material science and engineering, can solve the problems of dispersibility and instability limiting applications, achieve short preparation process, enhance water solubility and moisture retention, overcome High dispersion effect

Active Publication Date: 2021-06-01
SOUTH CHINA INST OF COLLABORATIVE INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although nanosilver has excellent antibacterial properties, its dispersion and instability limit its application

Method used

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  • A low-molecular-weight chitosan@silver nanoparticle composite film and its preparation method and application
  • A low-molecular-weight chitosan@silver nanoparticle composite film and its preparation method and application
  • A low-molecular-weight chitosan@silver nanoparticle composite film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0050] Dissolve 4.00g chitosan in 200mL HAc-NaAc solution with pH=4.5, stir evenly to make it completely dissolved, add 0.20g papain, stir and react for 11.5 hours at a constant temperature of 45°C, heat up to 60°C constant temperature, and then add Added 40mL H 2 o 2 The solution was reacted for 30 minutes, heated at 100°C for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate low-molecular-weight chitosan, which was separated by suction filtration and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-1.

[0051] Then, weigh 0.4762g of LMWC-1 sample and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it uniformly dispersed, and then add 1mL of 20mg / mL AgNPs disper...

Embodiment 2

[0052] Example 2: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0053] Dissolve 4.00g chitosan in 200mL HAc-NaAc with pH = 4.5, stir evenly to dissolve completely, add 0.40g papain, stir and react at a constant temperature of 45°C for 11.5 hours, raise the temperature to 60°C constant temperature, and add to it Add 40mL H 2 o 2 The solution was reacted for 30 minutes, boiled in water bath for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate the low-molecular-weight chitosan product, separated by suction filtration, and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-2. Weigh 0.4762g of LMWC-2 sample and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it evenly dispersed, and then add 1mL of 20mg / mL AgNPs dispersion (sonicat...

Embodiment 3

[0054] Example 3: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0055] Dissolve 4.00g chitosan in 200mL HAc-NaAc with pH = 4.5, stir evenly to dissolve it completely, add 0.27g papain, stir and react at a constant temperature of 45°C for 11.5 hours, raise the temperature to a constant temperature of 60°C, and add to it Add 40mL H 2 o 2 The solution was reacted for 30 minutes, boiled in water bath for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate low-molecular-weight chitosan, which was separated by suction filtration and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-3. Weigh 0.4762g of LMWC-3 and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it evenly dispersed, and then add 1mL of 20mg / mL AgNPs dispersion (cleaned b...

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Abstract

The invention belongs to the field of material science and engineering technology, and discloses a low-molecular-weight chitosan@silver nanoparticle composite film, a preparation method, and an application in the fields of antibacterial and anticorrosion. The preparation method of the present invention comprises the following steps: adding enzyme powder into a buffer solution of polymer chitosan, stirring and reacting at 30-60° C. for 10-14 hours, and then adding H 2 o 2 The solution was reacted at 50-80°C for 20-60 minutes, then heated at 90-110°C for 5-10 minutes, suction filtered, separated, and heated to activate to obtain the end product of low-molecular chitosan; add it and polyvinyl alcohol into water, and mix well , adding AgNPs dispersion liquid, stirring at 30-90° C. for 4-5 hours, and then stirring in a cell pulverizer for 1-2 hours to obtain an electrospinning solution; spinning to obtain a low-molecular-weight chitosan@silver nanoparticle composite film. The composite membrane of the invention has excellent performance, stronger antibacterial effect and bacteria interception ability, and can be applied in the fields of antibacterial, anticorrosion and the like.

Description

technical field [0001] The invention belongs to the field of material science and engineering technology, and in particular relates to a low-molecular-weight chitosan@silver nanoparticle composite film, its preparation method and its application in the antibacterial and antiseptic fields. Background technique [0002] With the progress of human beings, people place higher expectations on human health, and the safety standards for daily chemicals are getting higher and higher. As one of the indispensable additives in the daily chemical industry, preservatives have safety standards will also increase. Preservatives are generally divided into synthetic preservatives and natural preservatives. Synthetic preservatives are mostly used now, but long-term studies have found that some synthetic preservatives have problems such as carcinogenicity, teratogenicity, and poisoning. 2009 "Johnson & Johnson Toxic" incident: Johnson & Johnson's baby bathroom products were exposed to contai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L3/3562A23L3/3571A23L3/358A61K8/19A61K8/73A61Q19/00A01N59/16A01N43/16A01N25/08A01N25/12A01P3/00A01P1/00
CPCA01N25/08A01N25/12A01N43/16A01N59/16A23L3/3562A23L3/3571A23L3/358A61K8/19A61K8/736A61K2800/524A61Q19/00
Inventor 程建华余林玲郑华生张鹏
Owner SOUTH CHINA INST OF COLLABORATIVE INNOVATION