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Orally taken preparation for lowering blood sugar and preparing method thereof

An oral preparation and hypoglycemic technology, applied in the field of medicine, can solve the problems of ineffective insulin action, obvious toxic and side effects, insulin deficiency, etc., and achieve the effects of reducing body weight, improving curative effect, and reducing blood lipids.

Inactive Publication Date: 2018-02-16
莫玉艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More than 90% of diabetic patients are type 2 diabetes. The ability to produce insulin in the body of type 2 diabetic patients is not completely lost. Some patients even produce too much insulin in the body. However, due to the enhanced insulin resistance of the body, the effect of insulin is not effective. Obviously, insulin deficiency in patients is therefore a relative deficiency
[0003] At present, the commonly used drugs for the treatment of diabetes include sulfonylureas, biguanides and α-glucosidase inhibitors, all of which have different degrees of defects when used alone, such as large dosage and obvious side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation of an oral preparation for hypoglycemia, the specific steps are:

[0021] Step 1: Take gliclazide 5g, metformin hydrochloride 20g, acarbose 5g, carboxymethyl cellulose 15g, magnesium stearate 0.5g, polacrilin potassium resin (IRP88) 4g, Aspartame 0.2g and mannitol 8g;

[0022] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0023] Step 3: Mix the drug-containing resin powder with gliclazide, acarbose, carboxymethylcellulose, magnesium stearate, aspartame, and mannitol evenly, and press into tablets, the specification of the tablet is 0.25g / tablet .

Embodiment 2

[0025] A preparation of an oral preparation for hypoglycemia, the specific steps are:

[0026] Step 1: Take gliclazide 5g, metformin hydrochloride 20g, acarbose 5g, carboxymethyl cellulose 15g, magnesium stearate 0.5g, polacrilin potassium resin (IRP88) 4g, Aspartame 0.2g and mannitol 8g;

[0027] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0028] Step 3: Mix the drug-containing resin powder with gliclazide, acarbose, carboxymethylcellulose, magnesium stearate, aspartame, and mannitol evenly, and press into tablets, the specification of the tablet is 0.25g / tablet .

Embodiment 3

[0030] A preparation of an oral preparation for hypoglycemia, the specific steps are:

[0031] Step 1: Take gliclazide 8g, metformin hydrochloride 18g, acarbose 8g, carboxymethylcellulose 12g, magnesium stearate 0.3g, polacrilin potassium resin (IRP88) 3g, Aspartame 0.5g and Mannitol 8g;

[0032] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0033] Step 3: Mix the drug-containing resin powder with gliclazide, acarbose, carboxymethylcellulose, magnesium stearate, aspartame, and mannitol evenly, and press into tablets, the specification of the tablet is 0.25g / tablet .

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PUM

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses an oral preparation for lowering blood sugar and a preparation method thereof, which consists of the following raw materials in terms of weight fraction: 5-10 parts of gliclazide, 15-20 parts of metformin hydrochloride, aka 5-10 parts of wave sugar, 10-15 parts of carboxymethyl cellulose, 0.1-0.5 parts of magnesium stearate, 1-5 parts of polacrilin potassium resin (IRP88), 0.1-0.5 parts of aspartame and mannitol 5‑10 servings. The present invention combines several hypoglycemic drugs with different effects, which have synergistic effects, complement each other, improve curative effect, effectively control blood sugar, reduce complications, and effectively reduce body weight and blood fat while lowering blood sugar.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation for lowering blood sugar and a preparation method thereof. Background technique [0002] Diabetes mellitus (Diabetes Inellitus) is a metabolic disease of multiple etiologies, characterized by chronic hyperglycemia, accompanied by disorders of sugar, fat and protein metabolism caused by defects in insulin secretion and / or action. Diabetes can occur at any age. As the course of the disease prolongs, it is easy to cause histopathological damage such as systemic nerve, microvascular and macrovascular lesions, and can lead to chronic and progressive lesions of the heart, brain, kidney, nerves and eyes and other tissues and organs, resulting in Blindness, lower extremity gangrene, uremia, stroke or myocardial infarction will eventually occur, and even life-threatening. With the improvement of living standards, diabetes has become a common disease, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/64A61K31/155A61K9/20A61P3/10
CPCA61K31/7036A61K9/0053A61K9/2054A61K31/155A61K31/64A61K2300/00
Inventor 莫玉艳
Owner 莫玉艳
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