Reaction-azeotropic distillation coupled ibuprofen ketalization technology and device

Abstract

The invention provides a reaction-azeotropic distillation coupled ibuprofen ketalization technology and device. The device is an integrated ketalization device integrating mixing, reaction and separation, and circular blending of materials is realized by combining mechanical stirring in a reaction kettle with outer circulation. The reaction space is expanded from the reaction kettle to a packing layer of a distillation tower, thereby further increasing the contact area of the reactants and improving the reaction rate. Coupling of reactive distillation and azeotropic distillation is realized through azeotropy between water and petroleum ether, and the conversion rate of the reactants is increased by removing the reaction water in time. The reaction time is further shortened by adopting thepetroleum ether with a large boiling range as a solvent and increasing the reaction temperature.

Description

technical field [0001] The invention belongs to the field of reactive distillation in the chemical industry, and in particular relates to a technology and device for ibuprofen ketalization reaction, and is especially suitable for shortening the liquid-liquid heterogeneous reaction time in the chemical production process. Background technique [0002] The chemical name of ibuprofen is ibuprofen, which is the basic raw material for the production of anti-inflammatory, antipyretic and analgesic synthetic agents, as well as the base for the preparation of ibuprofen methyl ester, peptide surfactants, and polymerizable ethylenic monomers. base compound. As a non-steroidal anti-inflammatory drug, ibuprofen has significant medical effects and few adverse reactions, and is one of the best-selling over-the-counter drugs in the world. [0003] The production of ibuprofen currently adopts the 1,2-transposition rearrangement process. The main production processes are Friedel-Crafts acyl...

AI Technical Summary

Problems solved by technology

[0010] (1) Solve the problem of uneven mixing of materials in the original batch reactor, and promote the uniform distribution of catalyst sulfuric acid in the system; (2) Solve the problem that the product water is difficult to remove from the reaction system in time, and promote the positive movement of the reaction; (3) Solve the problem of high content of neopentyl glycol in the distilled water, and promote the clean production of the reaction

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