Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of artemisinin microcapsule

A technology for artemisinin and microcapsules is applied in the field of preparation of artemisinin microcapsules, which can solve the problems of nutrient loss, quality decline, oxidative degradation and the like, and achieve the effects of improving water solubility, improving compactness and good dispersibility.

Active Publication Date: 2018-03-13
右江民族医学院
View PDF8 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, artemisinin dry powder is not protected by other media, and it is prone to oxidative degradation under the action of light, high temperature and oxygen, resulting in nutrient loss and quality degradation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of artemisinin microcapsules, comprising the following steps:

[0024] (1) Prepare the core material: dissolve artemisinin in ethanol with a weight ratio of 6 times, then add sodium starch phosphate and Tween emulsifier with a mass ratio of 1:5, the weight ratio of artemisinin to emulsifier 5:1, stir evenly to obtain core material solution;

[0025] (2) Prepare the wall material: Chitosan, carboxymethyl chitosan octadecyl quaternary ammonium salt and gelatin with a mass ratio of 1:0.3:2 are used as the wall material, and water with a weight of 7 times the weight of the wall material is added. Raise the temperature to 50°C and stir evenly to obtain wall material suspension;

[0026] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:4, and homogenize for 30 minutes at an ultrasonic power of 200W and a temperature of 50°C to obtain a milky pr...

Embodiment 2

[0030] A preparation method of artemisinin microcapsules, comprising the following steps:

[0031] (1) Prepare the core material: dissolve artemisinin in ethanol with a weight ratio of 8 times, then add sodium starch phosphate and Tween emulsifier with a mass ratio of 1:3, the weight ratio of artemisinin to emulsifier 4:1, stir evenly to obtain core material solution;

[0032] (2) Prepare the wall material: Chitosan, carboxymethyl chitosan octadecyl quaternary ammonium salt and gelatin with a mass ratio of 1:0.1:4 are used as the wall material, and water 6 times the weight of the wall material is added, Raise the temperature to 55°C and stir evenly to obtain wall material suspension;

[0033] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:5, and homogenize for 30 minutes at an ultrasonic power of 150W and a temperature of 55°C to obtain a milky product;

[0034] ...

Embodiment 3

[0037] A preparation method of artemisinin microcapsules, comprising the following steps:

[0038] (1) Prepare the core material: dissolve artemisinin in ethanol with a weight ratio of 7 times, then add sodium starch phosphate and Tween emulsifier with a mass ratio of 1:4, the weight ratio of artemisinin to emulsifier 6:1, stir evenly to obtain core material solution;

[0039] (2) Prepare the wall material: Chitosan, carboxymethyl chitosan octadecyl quaternary ammonium salt and gelatin with a mass ratio of 1:0.5:3 are used as the wall material, and water is added that is 8 times the weight of the wall material. Raise the temperature to 60°C and stir evenly to obtain wall material suspension;

[0040] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:3, and homogenize for 20 minutes at an ultrasonic power of 250W and a temperature of 60°C to obtain an emulsion;

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of an artemisinin microcapsule, comprising: dissolving artemisinin in ethanol having the weight ratio of 6-8, adding sodium starch phosphate and a tween emulsifier, and stirring well to obtain a core solution; using chitosan, octadecyl quaternary ammonium salt of carboxymethyl chitosan and gelatin as a wall material, adding water 6-8 times as heavy as the wall material, heating to 50-60 DEG C, and stirring well to obtain a wall suspension; adding the core solution and the wall suspension into an ultrasonic homogenizer at the weight ratio of 1:(3-5)to perform homogenizing for 20-30 min to obtain an emulsion; delivering the emulsion to a granulating sprayer to perform spray drying, cooling to room temperature, and packaging to obtain the artemisinin microcapsule. The artemisinin microcapsule prepared herein can provide isolation of its effective ingredients with the outside and protect them from being influenced by heat sources, light sources, air and the like, stability of artemisinin is significantly improved, the shelf life is significantly extended, active ingredients of artemisinin can be well preserved, and processing, storing and transporting of artemisinin are facilitated.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine processing, in particular to a preparation method of artemisinin microcapsules. Background technique [0002] Artemisia annua, also known as Artemisia annua, is an annual herb of Compositae, widely distributed throughout my country. Artemisia annua contains a variety of volatile and non-volatile medicinal components. The non-volatile components mainly include artemisinin, artemisinin, B, C, artemisinin, coumarin, and flavonoids. Artemisinin can be used to control the symptoms of vivax malaria and falciparum malaria in the field, as well as the treatment of chloroquine-resistant strains. It can also be used to treat dangerous types of falciparum malaria, such as cerebral type and icteric type, and can also be used to treat systemic lupus erythematosus and discitis. Symptomatic lupus erythematosus. Similarly, artemisinin can be used as a raw material to prepare its derivatives...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/366A61K47/36A61K47/42A61P33/06A61P37/02
CPCA61K9/5036A61K9/5052A61K31/366
Inventor 黄锁义黄与路
Owner 右江民族医学院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com