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Biomedical gel and preparation method thereof

A biomedical and gel technology, which is applied in the field of biomedical gel and its preparation, can solve the problems of easy sliding of anti-adhesion film, poor adhesion, trauma, etc., and achieve good injectability and good tissue adhesion Effect

Inactive Publication Date: 2018-03-16
GUANGZHOU SUN SHING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Good self-adhesion performance, poor adhesion, surgical adhesion membranes are greatly restricted in application, such as between the peritoneum and the intestinal tube, between the intestinal tube and the intestinal tube, because the intestinal tube is in constant peristalsis, the anti-adhesion membrane is easy to Slipping, potentially causing new trauma to otherwise healthy parts

Method used

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  • Biomedical gel and preparation method thereof
  • Biomedical gel and preparation method thereof

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Effect test

Embodiment 1

[0030] An embodiment of the preparation method of the biomedical gel of the present invention, the preparation method of the biomedical gel described in this embodiment is:

[0031] Dissolve polyglutamic acid in deionized water, stir evenly, and prepare a polyglutamic acid aqueous solution with a concentration of 1w / v%; pass nitrogen gas into the prepared polyglutamic acid aqueous solution as a protective atmosphere and seal the package; The equine ray irradiates the aqueous solution of polyglutamic acid with a dose of 50 kGy to cross-link to form polyglutamic acid gel and obtain biomedical gel.

Embodiment 2

[0033] An embodiment of the preparation method of the biomedical gel of the present invention, the preparation method of the biomedical gel described in this embodiment is:

[0034] Dissolve polyglutamic acid in deionized water, stir evenly, and prepare a polyglutamic acid aqueous solution with a concentration of 4w / v%; pass nitrogen into the prepared polyglutamic acid aqueous solution as a protective atmosphere and seal the package; The equine ray irradiates the polyglutamic acid aqueous solution with a radiation dose of 45kGy, cross-links to form polyglutamic acid gel, and obtains biomedical gel.

Embodiment 3

[0036] An embodiment of the preparation method of the biomedical gel of the present invention, the preparation method of the biomedical gel described in this embodiment is:

[0037] Dissolve polyglutamic acid in deionized water, stir evenly, and prepare a polyglutamic acid aqueous solution with a concentration of 7w / v%; pass nitrogen into the prepared polyglutamic acid aqueous solution as a protective atmosphere and seal the package; The horse ray irradiates the polyglutamic acid aqueous solution with a radiation dose of 35kGy, cross-links to form a polyglutamic acid gel, and obtains a biomedical gel.

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Abstract

The invention discloses a biomedical gel and a preparation method thereof. Polyglutamic acid and deionized water which are used as raw materials undergo irradiation cross-linking to form polyglutamicacid gel in order to obtain the biomedical gel is The biomedical gel having different degradation times is produced through adjusting the irradiation dose without adding a chemical cross-linking agentin order to meet requirements of different wound parts; and the biomedical gel has a certain haemostasis function, and can be used for preventing adhesion of the bleeding parts; and when the biomedical gel is in a wet state, the biomedical gel has good tissue adherence and avoids stitching.

Description

technical field [0001] The invention relates to the field of medical gel materials, in particular to a biomedical gel and a preparation method thereof. Background technique [0002] Tissue adhesion after surgery has always been a major problem in clinical medicine. There are nearly 10 million surgical cases of various types in the country every year, and almost all operations involve anti-adhesion between tissues and local anti-inflammation. Tissue adhesions after surgical operations on the human abdomen, cardiovascular, spine, bone joints, legs, and gynecological pelvic cavity not only bring great pain to patients, but also cause huge economic losses. Postoperative adhesions can cause serious complications, such as abdominal and pelvic cavity can cause adhesive ileus, recurrent laryngeal nerve injury after thyroid surgery, heart and thoracic adhesions require another thoracotomy, and pelvic tissue Female infertility caused by adhesions, and tissue adhesions are also the ma...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/14A61L26/00C08L77/04C08J3/075C08J3/28
CPCA61L26/0019A61L26/008A61L26/009A61L31/06A61L31/145A61L31/148A61L2400/04A61L2400/06C08J3/075C08J3/28C08J2377/04C08L77/04
Inventor 谭睿哲邹鹏杨习锋曾晨光
Owner GUANGZHOU SUN SHING BIOTECH CO LTD