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Composite ceramic scaffold and preparation method thereof

A technology of composite ceramics and porous ceramics, applied in coatings, medical science, prostheses, etc., can solve the problems of inflammation, BMP-2 protein is extremely expensive, and has no advantages, so as to promote osteogenic differentiation and safe application Reliable and accelerated bone regeneration effect

Active Publication Date: 2018-04-10
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies have shown that the osteogenic activity of the composite scaffold is mainly derived from BMP-2 rather than the multilayer membrane, and the coating of the multilayer membrane on the ceramic scaffold has no advantage in in vitro cell experiments and in vivo ectopic osteogenesis experiments.
The use of BMP-2 protein is not only extremely expensive, but also has great hidden dangers, such as the risk of causing inflammation

Method used

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  • Composite ceramic scaffold and preparation method thereof
  • Composite ceramic scaffold and preparation method thereof
  • Composite ceramic scaffold and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Embodiment 1. alternately deposit chitosan solution (A solution, concentration 1mg / mL, pH4.0) and sodium hyaluronate solution (B solution, concentration 3mg / mL, pH3.0) on ceramic support surface, obtain 10 pairs of For the multi-layer film, soak the multi-layer film-coated stent in the carbodiimide-succinimide solution for 24 hours to cross-link, wash it thoroughly, dry it, and sterilize it for later use.

Embodiment 2

[0038] Example 2. Alternate deposition of polylysine solution (A solution, concentration 0.1mg / mL, pH9.5) and heparin sodium solution (B solution, concentration 5mg / mL, pH5.0) on the ceramic support surface to obtain 20 pairs of multi-layer film, soak the multi-layer film-coated stent in the genipin solution for 12 hours to cross-link, fully wash, dry, and sterilize for later use.

Embodiment 3

[0039]Embodiment 3. Aminated hyaluronic acid solution (A solution, concentration 5mg / mL, pH8.0) and chondroitin sulfate solution (B solution, concentration 0.1mg / mL, pH2.5) were alternately deposited on the ceramic support surface to obtain 5 For the double-layer multilayer film, soak the stent covered by the multilayer film in glutaraldehyde solution for 0.5 hour to cross-link, wash thoroughly, dry, and sterilize for later use.

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Abstract

The invention belongs to the field of biomedical materials, and relates to a composite ceramic scaffold and a preparation method thereof, in particular to preparation of a multi-layer membrane modified porous two-phase ceramic scaffold and application of the multi-layer membrane modified porous two-phase ceramic scaffold as a bone defect repair material. The preparation method of the composite ceramic scaffold comprises the following steps that the porous ceramic scaffold is soaked in a solution A, a washing solution C, a solution B and a washing solution D in sequence to obtain a double-layermembrane, the above step is repeated to obtain a plurality of double-layer membranes at least once, the double-layer membranes are soaked in an aqueous solution of a cross-linking agent for cross-linking for 30 minutes to 24 hours, and the membranes are fully cleaned in a cleaning solution to obtain the cross-linked composite ceramic scaffold. By means of the enrichment and riveting functions ofthe multi-layer membranes of the composite ceramic scaffold, medicines act on wounds in situ, osteogenesis differentiation of stem cells is promoted, and the composite ceramic scaffold has a great promotion effect on bone regeneration of osteoporosis patients.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite ceramic support and a preparation method thereof, in particular to the preparation of a porous dual-phase ceramic support modified by a multilayer film, and its application as a bone defect repair material. Background technique [0002] Bone defects caused by trauma, osteomyelitis, bone tumor resection, etc. often have a long treatment process and uncertain curative effect, causing great pain to patients both physically and mentally. At present, in the clinical treatment of bone defects, autologous ilium bone grafting and Ilizarov bone lengthening are mainly used. However, in the face of large bone defects, the amount of autologous bone cannot meet the demand, and the bone lengthening method requires patients to endure long-term pain and the risk of infection due to external fixation brackets. Therefore, it is often necessary to introduce artificial bon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/34A61L27/50A61L27/54A61L27/56
CPCA61L27/10A61L27/34A61L27/50A61L27/54A61L27/56A61L2300/428A61L2300/43A61L2300/606A61L2420/02A61L2420/06A61L2420/08A61L2430/02C08L5/08C08L5/04C08L5/10C08L77/04
Inventor 沈利燕唐千徐华梓
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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