Thermo-sensitive hydrogel and preparation method thereof

A temperature-sensitive hydrogel and temperature-sensitive monomer technology, applied in the field of polymer material synthesis, can solve the problems of high energy consumption and high cost of the preparation process

Inactive Publication Date: 2018-04-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because an external heat source is still required during the polymerization process, the preparation process consumes a lot of energy and costs high

Method used

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  • Thermo-sensitive hydrogel and preparation method thereof
  • Thermo-sensitive hydrogel and preparation method thereof
  • Thermo-sensitive hydrogel and preparation method thereof

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preparation example Construction

[0024] The invention provides a method for preparing a temperature-sensitive hydrogel, comprising the following steps: irradiating a temperature-sensitive monomer and a crosslinking agent in a solvent by ultraviolet light in the presence of a photoinitiator to perform a polymerization reaction , to obtain thermosensitive hydrogel; the photoinitiator has a photobleaching effect; the crosslinking agent is a substance with two functionalities.

[0025] Aiming at the technical status of the temperature-sensitive hydrogel preparation method, the present invention adopts the rapid, efficient and controllable polymerization method to prepare the temperature-sensitive hydrogel according to the principle of photofront polymerization, which can improve the temperature-sensitive hydrogel preparation. High efficiency, reducing the cost required for preparation.

[0026] In the embodiment of the present invention, a certain proportion of temperature-sensitive monomers, cross-linking agents...

Embodiment 1

[0040] Example 1: Preparation of Thermosensitive Hydrogel by Photofront Polymerization

[0041] Recipe ratio:

[0042] Monomer NIPAM, accounting for 56% of the total mass, 5.6g;

[0043] Crosslinking agent MBA, accounting for 1.5% of the total mass, 0.15g;

[0044] Photoinitiator TPO, accounting for 3.5% of the total mass, 0.35g;

[0045] Solvent DMSO, accounting for 39% of the total mass, 3.9g.

[0046] The preparation process is as follows:

[0047] (1) Mix 5.6g NIPAM, 0.15g MBA, 0.35g photoinitiator TPO and 3.9g DMSO, and perform ultrasonic vibration for 20min in a dark environment;

[0048] (2) Pour the mixed solution obtained in step (1) into figure 1 The reactor of the shown reaction device (a hollow glass tube with a rubber cap at one end, the size is an inner diameter of 8mm, and a length of 100mm), was left for 10 minutes, and the air bubbles in the glass tube were removed, and then it was placed under an ultraviolet light irradiation machine for 20 minutes. The...

Embodiment 2

[0072] Example 2: Preparation of Thermosensitive Hydrogel by Photofront Polymerization

[0073] Recipe ratio:

[0074] NIPAM, accounting for 56% of the total mass, 5.6g;

[0075] MBA, 1.5% of the total mass, 0.15g;

[0076] Photoinitiator 819, accounting for 3.5% of the total mass, 0.35g;

[0077] DMSO, accounting for 39% of the total mass, 3.9g.

[0078] The preparation process is as follows:

[0079] (1) Mix 5.6g NIPAM, 0.15g MBA, 0.35g photoinitiator 819 and 3.9g DMSO, and perform ultrasonic vibration for 20min in a dark environment;

[0080](2) Pour the mixed solution obtained in step (1) into a special reactor (same as Example 1) at a room temperature of 25°C and under the condition of avoiding light, and let it stand for 10 minutes to remove the air bubbles in the glass tube, and then put it Illuminate for 20 minutes under the ultraviolet light irradiation machine, and the light intensity is controlled at 5.0mW / cm 2 ;

[0081] (3) After the light is finished, take...

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Abstract

The invention provides a thermo-sensitive hydrogel and a preparation method thereof. The method comprises the following steps: dissolving a thermo-sensitive monomer and a cross-linking agent in a solvent, and carrying out a polymerization reaction through the irradiation of ultraviolet lights in the presence of a photoinitiator, so as to obtain the thermo-sensitive hydrogel, wherein the photoinitiator has a light bleaching effect, and the cross-linking agent is a substance with a bifunctional degree. According to the method disclosed by the invention, an external heating source is not needed,only the irradiation of the ultraviolet lights is needed, the reaction time is short, the pollution is avoided, the energy is saved, the environment is protected, the preparation method is efficient and controllable, and the prepared hydrogel has good thermal sensitivity, thermal stability and mechanical property. The poly(N-isopropylacrylamide) hydrogel with thermal sensitivity prepared by the embodiment of the invention has a diameter of about 10mm, the length can reach 80mm, the swelling rate at 25 DEG C is 400-1100%, the low critical phase transition temperature is 30-32 DEG C, and obviousthermal sensitivity is achieved.

Description

technical field [0001] The invention relates to the field of polymer material synthesis, in particular to a temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Thermosensitive hydrogel is a kind of smart hydrogel that responds to the external environment. It generally shrinks or swells to a certain extent according to the temperature change of the external environment, and has a low critical phase transition temperature (LCST ). The special swelling properties of thermosensitive hydrogels have been applied in the fields of controlled release of drugs, immobilization of enzymes and circulating absorbents. According to different performance requirements, appropriate monomers and their composition can be selected to prepare hydrogels. A common method for preparing thermosensitive hydrogels is solution polymerization, but this method has disadvantages such as long polymerization time and low degree of polymerization. [0003] The pri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F222/38C08F222/20C08F2/48
CPCC08F2/48C08F220/54C08F222/102
Inventor 苏嘉辉崔艳艳陈志康
Owner GUANGDONG UNIV OF TECH
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