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Application of dual-aliphatic-chain substituent phosphatidyl ethanolamine chitosan
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A technology based on phosphatidylethanolamine shell and lauroyl phosphatidylethanolamine, which is applied in the field of drug delivery, can solve the problems of leakage and destruction of encapsulated drugs, and achieve high biocompatibility, broad application prospects, and high drug delivery efficiency.
Active Publication Date: 2018-04-13
DALIAN NATIONALITIES UNIVERSITY
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The liposome structure is easily damaged by components such as high-density lipoprotein in serum, resulting in the leakage of encapsulated drugs
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Embodiment 2
[0038] Weigh 0.16g of formyl chitosan, disperse it into 20mL of methanol solution, add 0.14g of 1,2-dioleoylphosphatidylethanolamine, nitrogen protection, stir and react at 60°C for 42h, add 0.1g of sodiumborohydride and continue stirring at room temperature After 24 hours, the ethanolsolvent was removed by rotary evaporation, dispersed in water, dialyzed with deionized water, and freeze-dried to obtain 1,2-dioleoylphosphatidylethanolamine chitosan.
[0039] Prepare a 1mg / mL 1,2-dioleoylphosphatidylethanolamine aqueous solution, take 100uL, mix it with 1mL of DOTAP cationic liposome containing SPIO by ultrasound, then let it stand for 1h, and through the post-insertion self-assembly method, the The liposome is modified to obtain the liposome drug carrier with chitosan brushes on the surface.
Embodiment 3
[0041] Weigh 0.16g of formyl chitosan, disperse it into 20mL of methanol solution, add 0.14g of 1,2-dilauroylphosphatidylethanolamine, under nitrogen protection, stir and react at 60°C for 42h, add 0.1g of sodiumborohydride and continue stirring at room temperature After 24 hours, the ethanolsolvent was removed by rotary evaporation, dispersed in water, dialyzed with deionized water, and freeze-dried to obtain 1,2-dilauroylphosphatidylethanolamine chitosan.
[0042] Prepare a 1mg / mL 1,2-dilauroylphosphatidylethanolamine aqueous solution, take 100uL, mix it with 1mL of DOTAP cationic liposomes containing SPIO by ultrasound, then let it stand for 1h, and pass the post-insertion self-assembly method. The liposome is modified to obtain the liposome drug carrier with chitosan brushes on the surface.
Embodiment 4
[0044] Weigh 0.16g of formyl chitosan, disperse it into 20mL of methanol solution, add 0.14g of 1,2-dimyristoylphosphatidylethanolamine, under nitrogen protection, stir and react at 60°C for 42h, add 0.1g of sodiumborohydride and continue at room temperature Stir for 24 hours, remove the ethanolsolvent by rotary evaporation, disperse into water, dialyze with deionized water, and freeze-dry to obtain 1,2-dimyristoylphosphatidylethanolamine chitosan.
[0045] Prepare a 1mg / mL aqueous solution of 1,2-dimyristoylphosphatidylethanolamine, take 100uL, mix it with 1mL of DOTAP cationic liposomes containing SPIO by ultrasonication, then let it stand for 1h, and pass the post-insertion self-assembly method, The liposome is modified to obtain the liposome drug carrier with chitosan brushes on the surface.
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[0001] This application is a divisional application with the application number 2017106207042, the application date is July 27, 2017, and the invention title is "Double fatty chain substituent phosphatidylethanolamine chitosan and its preparation method and application". technical field [0002] The present invention relates to a kind of double fatty chain substituent phosphatidylethanolamine chitosan and its liposomedrug carrier, in particular to a kind of double fatty chain substituent phosphatidylethanolamine chitosan and its liposome construction package The invention relates to a drug carrier of superparamagnetic iron ferricoxide nanoparticles, which belongs to the preparation method of a novel drug carrier in the field of drug delivery. Background technique [0003] A drug carrier refers to a system that can change the way a drug enters the human body and its distribution in the body, controls the release rate of the drug, and delivers the drug to the target organ. D...
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