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Thermosensitive gold nanocage and its preparation method and application, drug-loaded thermosensitive gold nanocage and its preparation method

A gold nano-cage and nano-cage technology, which can be used in pharmaceutical formulations, anti-tumor drugs, drug combinations, etc., can solve the problems of inability to cure tumors, uneven heat distribution, and lack of targeting, avoiding decomposition and elimination in vivo. High repeatability and improved stability

Active Publication Date: 2021-02-19
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the uneven heat distribution inside the tumor, a single photothermal therapy is not enough to kill all tumor cells, resulting in incomplete tumor ablation and tumor recurrence, while single drug chemotherapy has no targeting, and side effects are large, and it cannot cure the tumor

Method used

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  • Thermosensitive gold nanocage and its preparation method and application, drug-loaded thermosensitive gold nanocage and its preparation method
  • Thermosensitive gold nanocage and its preparation method and application, drug-loaded thermosensitive gold nanocage and its preparation method
  • Thermosensitive gold nanocage and its preparation method and application, drug-loaded thermosensitive gold nanocage and its preparation method

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preparation example Construction

[0043] According to the second aspect of the present invention, the present invention provides the preparation method of the above-mentioned temperature-sensitive gold nanocages, comprising the following steps: first mixing the temperature-sensitive liposomes with the gold nanocages, so that the temperature-sensitive liposomes are coated on the gold nanocages The outer surface of the thermosensitive gold nanocage is made;

[0044] Preferably, the mass ratio of thermosensitive liposomes and gold nanocages is (45-60): 1, preferably (48-52): 1;

[0045] Preferably, the temperature-sensitive liposome is coated on the outer surface of the gold nanocage by ultrasonic dispersion, so as to obtain the temperature-sensitive gold nanocage.

[0046] In the present invention, a typical but non-limiting preparation method of temperature-sensitive gold nanocages includes the following steps: firstly, gold nanocages are dispersed in a solution, and then temperature-sensitive liposomes are add...

Embodiment 1

[0077] This embodiment provides a temperature-sensitive gold nanocage, comprising a hollow porous gold nanocage with a particle size of 70nm, and the outside of the gold nanocage is coated with a temperature-sensitive liposome layer with a thickness of 3nm, the temperature-sensitive liposome layer Consisting of (1,2 distearoylcholine-sn-glycerol-3-phosphoethanolamine-maleimide)-polyethylene glycol, dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine Alkali and cholesterol, the mass ratio of the four is 8:1:3:5.

Embodiment 2

[0079] This embodiment provides a temperature-sensitive gold nanocage. The difference between this embodiment and Example 1 is that the temperature-sensitive liposome layer has a thickness of 8 nm, and the temperature-sensitive liposome layer is composed of (1,2 dihard Esterylcholine-sn-glycerol-3-phosphoethanolamine-maleimide)-polyethylene glycol, dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine and cholesterol, The mass ratio of the four is 12:2:1:7.

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Abstract

The invention provides a temperature-sensitive gold nanocage and its preparation method and application, a drug-loaded temperature-sensitive gold nanocage and its preparation method, and relates to the technical field of drug carriers, including a gold nanocage, the gold nanocage is a hollow porous structure, and the gold nanocage The outer surface is covered with thermosensitive liposomes, which alleviates one of the technical problems in the prior art that single photothermal therapy is not enough to kill all tumor cells, and single drug chemotherapy has no targeting and side effects First, by using gold nanocages as drug carriers and photothermal agents, drugs can be delivered efficiently in vivo and photothermally treated tumors; by coating thermosensitive liposomes on the outer surface of gold nanocages, By utilizing the photothermal conversion performance of gold nanocages, the temperature of the thermosensitive liposome is raised to the phase transition temperature, so that the drug is released rapidly, so as to achieve the technical effect of photothermal-drug combination efficient and controllable treatment of malignant tumors.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to a temperature-sensitive gold nanocage and its preparation method and application, a drug-loaded temperature-sensitive gold nanocage and its preparation method. Background technique [0002] At present, malignant tumors are still one of the major diseases that threaten human life and health, and the incidence of cancer worldwide is on the rise. The treatment of malignant tumors has always been a difficulty in research at home and abroad. The methods of clinical treatment of cancer include surgery, radiation therapy, photothermia and drug chemotherapy. Photothermal therapy has attracted widespread attention due to its ability to significantly improve the anti-tumor effect of drugs. Its principle is to use targeting technology to gather photothermal agents with high photothermal conversion efficiency near the tumor tissue, and convert the photothermal agent under the irradiati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/127A61P35/00
CPCA61K9/127A61K41/0028A61K41/0052A61K2300/00
Inventor 蔡林涛韩志群梁锐晶郑明彬刘陈立
Owner SHENZHEN INST OF ADVANCED TECH
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