Dendrobium candidum polysaccharide and polygonatum polysaccharide composition and preparation method and application thereof

A technology of Dendrobium officinale polysaccharide and Polygonum polysaccharide is applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of environmental damage of growth, limited wild resources, inability to meet market demand, etc., and achieves convenient administration and high bioavailability. , the effect of large market potential

Inactive Publication Date: 2018-05-22
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Dendrobium officinale is a precious medicinal material, and its market demand has continued to increase in recent years. However, due to its limited wil

Method used

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  • Dendrobium candidum polysaccharide and polygonatum polysaccharide composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of Dendrobium officinale polysaccharide and Polygonatum polysaccharide composition

[0023] Preparation of polysaccharides from Dendrobium officinale: crush the washed and dried medicinal material of Dendrobium officinale with a pulverizer, pass through a 60-mesh sieve, add 15 times the volume of deionized water to soak, raise the temperature to 60°C to extract once, each time for 1.5h, and centrifugally filter , the extract was concentrated in vacuo, added 4 times the volume of 95% ethanol to dissolve, allowed to settle overnight, centrifuged to remove the supernatant, precipitated and dried to obtain polysaccharides from Dendrobium officinale. The content of total polysaccharides was 61% as detected by the sulfuric acid-phenol method, with glucose as the reference substance.

[0024] Preparation of Rhizoma Polygonatum Polysaccharide: After the washed and dried Rhizoma Polygonatum is pulverized with a pulverizer, pass through a 60-mesh sieve, ...

Embodiment 2

[0026] Embodiment 2: the preparation of dendrobium officinale polysaccharide and polygonatum polysaccharide composition

[0027] Preparation of polysaccharides from Dendrobium officinale: crush the washed and dried medicinal material of Dendrobium officinale with a pulverizer, pass through an 80-mesh sieve, add 30 times the volume of deionized water to soak, heat up to 80°C to extract twice, each time for 2.5h, and centrifuge , the extract was concentrated in vacuo, added 4 times the volume of 95% ethanol to dissolve, allowed to settle overnight, centrifuged to remove the supernatant, precipitated and dried to obtain polysaccharides from Dendrobium officinale. The content of total polysaccharides is 70% as detected by the sulfuric acid-phenol method, with glucose as the reference substance.

[0028] Preparation of Rhizoma Polygonatum Polysaccharide: After the washed and dried Polygonatum medicinal material is pulverized with a pulverizer, pass through a 80-mesh sieve, add 30 t...

Embodiment 3

[0030] Embodiment 3: the preparation of dendrobium officinale polysaccharide and polygonatum polysaccharide composition

[0031] Preparation of Dendrobium officinale polysaccharides: After the washed and dried medicinal materials of Dendrobium officinale were pulverized with a pulverizer, passed through a 100-mesh sieve, soaked in 40 times the volume of deionized water, heated to 100°C, extracted 3 times, each time for 3 hours, and centrifuged. The extract was concentrated in vacuo, dissolved by adding 4 times the volume of 95% ethanol, allowed to settle overnight, centrifuged to remove the supernatant, precipitated and dried to obtain the polysaccharide of Dendrobium officinale. The content of total polysaccharides was 61% as detected by the sulfuric acid-phenol method, with glucose as the reference substance.

[0032] Preparation of Rhizoma Polygonatum Polysaccharide: After crushing the washed and dried Polygonatum medicinal material with a pulverizer, pass through a 100-mes...

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Abstract

The invention discloses a dendrobium candidum polysaccharide and polygonatum polysaccharide composition and a preparation method and application thereof, and relates to dendrobium candidum and polygonatum. The dendrobium candidum polysaccharide and polygonatum polysaccharide composition comprises dendrobium candidum polysaccharide and polygonatum polysaccharide, wherein the dendrobium candidum polysaccharide has the total polysaccharide content being higher than 50%; the polygonatum polysaccharide has the total polysaccharide content being higher than 50%; the mass ratio of the dendrobium candidum polysaccharide to the polygonatum polysaccharide is 4:1. The preparation method comprises the following steps: 1), preparing the dendrobium candidum polysaccharide; 2), preparing the polygonatumpolysaccharide; 3), combining the dendrobium candidum polysaccharide obtained in the step 1) and the polygonatum polysaccharide obtained in the step 2) to obtain the dendrobium candidum polysaccharideand polygonatum polysaccharide composition. The dendrobium candidum polysaccharide and polygonatum polysaccharide composition can adopt pharmaceutically acceptable dosage forms. The dendrobium candidum polysaccharide and polygonatum polysaccharide composition has the effects of enhancing immunity, relieving physical fatigue and the like, so that the dendrobium candidum polysaccharide and polygonatum polysaccharide composition can be applied to preparation of medicines with the efficacies of enhancing the immunity, relieving the physical fatigue and the like.

Description

technical field [0001] The invention relates to dendrobium officinale and sealwort polysaccharide, in particular to a composition of dendrobium officinale polysaccharide and sealwort polysaccharide, a preparation method and application thereof. Background technique [0002] Dendrobium officinale Kimura et Migo is the dried stem of Dendrobium officinale Kimura et Migo. It is a traditional precious Chinese medicine in my country. It has been known as "gold in medicine" since ancient times. There is a record in "Superior Injury, Eliminate Bibiosis, Lower Qi, Tonify the Deficiency and Leanness of the Five Zang-organs, Strengthen Yin, and Thicken the Stomach" after long-term use. Clearing away heat, benefiting stomach and promoting body fluid etc. [0003] Modern pharmacological studies have shown that Dendrobium officinale has the functions of enhancing immunity, anti-fatigue, anti-oxidation, lowering blood sugar, lowering blood pressure, anti-liver damage, and anti-tumor. Its ma...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/48A61P37/04A61P39/00
CPCA61K31/715A61K9/4866A61K36/8969A61K36/8984A61K2300/00
Inventor 吴振薛识符文豪
Owner XIAMEN UNIV
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