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Sugar-free type folium ginkgo and fiveleaf gynostemma herb collaterals-dredging soft capsules and preparation method thereof

A sugar-free, soft capsule technology, applied in capsule delivery, pharmaceutical formulations, medical raw materials derived from ginkgo biloba, etc., can solve problems such as low bioavailability, gastrointestinal discomfort, poor drug stability, etc., to avoid increased blood sugar, no Adverse reactions, good stability

Inactive Publication Date: 2018-05-29
GUILIN HONGHUI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this oral liquid is not suitable for patients with hyperglycemia because honey contains too many carbohydrates, and honey does not show a clear curative effect in this preparation, and patients will experience increased blood sugar; and the oral liquid is taken in a large amount, and patients After use, it is easy to cause gastrointestinal discomfort, slow absorption, slow effect, and poor drug stability and low bioavailability
[0005] These Chinese herbal dosage forms of the prior art create troubles, and patients have side effects after use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: A sugar-free traditional Chinese medicine Yinlan Tongluo Soft Capsule for oral administration

[0028] The soft capsule is composed of an encapsulation liquid and a capsule shell, wherein the encapsulation liquid is composed of 100 g of Ginkgo biloba leaves, 150 g of Gynostemma pentaphyllum in parts by weight, soybean oil as a dispersant, beeswax as a suspending agent, and soybean lecithin as a surfactant. constitute. Wherein the weight ratio of above-mentioned Chinese medicine extract and soybean oil, beeswax and soybean lecithin is 1~2: 3~5: 0.05~0.2: 0.1~0.3; 0.35, water 0.8 ~ 1.2 made. The recipe is:

[0029] (1) Preparation of the extract: take the above two herbs, add 8-10 times of water to extract twice at 90-100°C, the first time for 2 hours, the second time for 1 hour, filter, combine the filtrates, and extract Concentrate the solution to a relative density of 1.1-1.2, add ethanol to make the alcohol concentration of the drug solution 40%-60%, lea...

Embodiment 2

[0035] Example 2: A sugar-free traditional Chinese medicine Yinlan Tongluo Soft Capsule for oral administration

[0036] The soft capsule is composed of an encapsulation liquid and a capsule shell, wherein the encapsulation liquid is composed of 102 g of Ginkgo biloba leaves, 153 g of Gynostemma pentaphylla 153 g, dispersant soybean oil, suspending agent beeswax and surfactant soybean lecithin constitute. Wherein the weight ratio of above-mentioned Chinese medicine extract and soybean oil, beeswax and soybean lecithin is 1~2: 3~5: 0.05~0.2: 0.1~0.3; 0.35, water 0.8 ~ 1.2 made. Preparation method is the same as embodiment 1.

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PUM

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Abstract

The invention provides sugar-free type folium ginkgo and fiveleaf gynostemma herb collaterals-dredging soft capsules. Each capsule is prepared from two parts including capsulation liquid and a capsuleshell, wherein the capsulation liquid is prepared from extract of 80 to 120 parts of folium ginkgo by weight and 130 to 180 parts of fiveleaf gynostemma herb by weight, a dispersant soybean oil, a suspending aid bee wax and a surfactant soybean phospholipid; the weight ratio of the traditional Chinese medicine extract to the soybean oil to the bee wax to the soybean phospholipid is (1 to 2) to (3to 5) to (0.05 to 0.2) to (0.1 to 0.3); the capsule shell is prepared from the following components in parts by weight: 0.9 to 1.1 parts of gelatin, 0.15 to 0.35 part of glycerol and 0.8 to 1.2 partsof water. A preparation method comprises the following steps: (1) preparing extract; (2) adding an auxiliary material; (3) dissolving glue; (4) injecting the glue; (5) preparing a capsule material; (6) preparing the capsules. The soft capsules provided by the invention do not contain honey and a phenomenon that the blood glucose of patients is increased is avoided; the soft capsules also have theadvantages of high efficiency, rapid effect, long effect, small toxicity, no adverse effect, small dosage and good stability, and are applicable to various diseases of qi deficiency and blood stasissyndromes.

Description

technical field [0001] The present invention relates to pharmaceutical preparations, and more specifically, to medicines with ginkgo biloba and Jiaogulan extracts as active ingredients. technical background [0002] Qi-deficiency and blood-stasis syndrome is a symptom manifested by qi-deficiency and blood-flow stagnation. It is often caused by prolonged illness due to Qi deficiency, which gradually leads to internal stagnation of blood stasis. Clinical manifestations Pale or dull complexion, tired body, lack of energy, lack of breath, pain like thorns, common in the chest and flanks, pain does not move, refusal to press, dark tongue or purple spots, deep and astringent pulse. Syndrome analysis Qi deficiency and blood stasis sandwich excess in deficiency, and the symptoms of qi deficiency and blood stasis are the main points of syndrome differentiation. Pale complexion, tired body, lack of qi and lack of energy to speak, is a syndrome of qi deficiency; qi deficiency is unab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/424A61K9/48A61K47/44A61K47/24A61P9/12A61P1/08A61P27/16A61P25/00A61P29/00A61P25/28A61P1/14A61P25/20A61P9/10A61P9/06A61P39/00
CPCA61K36/16A61K9/4833A61K9/4858A61K36/424A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 苏建会文艺何珺黄礼杰
Owner GUILIN HONGHUI PHARMA CO LTD
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