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Polyurethane foam dressing and preparation method thereof

A technology of polyurethane foam and water-based polyurethane, applied in the field of medicine, can solve problems such as secondary trauma, wound dressing adhesion, easy breeding of bacteria, etc., and achieve the effect of increasing speed

Active Publication Date: 2018-05-29
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional wound dressings (such as gauze and cotton) have many disadvantages: they are easy to breed bacteria, and the wound exudate easily forms scabs with dry dermal tissue, which hinders epithelialization; at the same time, the wound is easy to adhere to the dressing, causing pain when the dressing is removed , causing secondary trauma
Although these new polyurethane foam dressings can promote the healing of wound tissue and have a certain bactericidal effect, they cannot inhibit the formation of wound scars, or the inhibitory effect is weak, so patients still need to use other scar repair products after the wound has healed

Method used

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  • Polyurethane foam dressing and preparation method thereof
  • Polyurethane foam dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 polyurethane foam dressing of the present invention

[0043] raw material:

[0044] 80 parts of Bayhydur 2547, 12 parts of carboxymethyl chitosan, 0.2 parts of tetrandrine, 0.1 part of tamoxifen, 60 parts of diphenylmethane diisocyanate (MDI), 2 parts of sodium lauryl sulfate, 1 part of stannous octoate , 2 parts of tetrahydrofuran, and 100 parts of purified water. Wherein the degree of substitution of carboxymethyl chitosan is 85%, and the degree of deacetylation is 90%.

[0045] Preparation:

[0046] ①Weigh Bayhydur 2547, tetrahydrofuran, carboxymethyl chitosan, tetrandrine, tamoxifen, sodium lauryl sulfate, stannous octoate, purified water respectively in the proportioning by weight, at room temperature, 2500r / min After stirring for 4 minutes under the same conditions.

[0047] ② Weigh and add the diphenylmethane diisocyanate (MDI) in the proportion by weight, continue stirring for 1 minute, put it into a foaming mold and keep it w...

Embodiment 2

[0048] Embodiment 2 The preparation of polyurethane foam dressing of the present invention

[0049] raw material:

[0050] 90 parts of Bayhydur2655, 15 parts of hydroxypropyl chitosan, 0.1 part of tetrandrine, 0.2 part of tamoxifen, 120 parts of diphenylmethane diisocyanate (MDI), 3 parts of silicone oil, 2 parts of stannous octoate, 3 parts of petroleum ether , 120 parts of purified water. Among them, the degree of substitution of hydroxypropyl chitosan is 80%, and the degree of deacetylation is 85%.

[0051] Preparation:

[0052] ① Weigh Bayhydur 2655, petroleum ether, hydroxypropyl chitosan, tetrandrine, tamoxifen, organic silicone oil, stannous octoate, purified water and stir at room temperature for 5 minutes under the condition of 2000r / min rear.

[0053] ②Weigh and add the diphenylmethane diisocyanate (MDI) in the proportion by weight, continue to stir for 1min, put it into a foaming mold and keep it warm at 60°C for 40 minutes, and cut it to obtain a polyurethane f...

Embodiment 3

[0054] Embodiment 3 The preparation of polyurethane foam dressing of the present invention

[0055] raw material:

[0056] 85 parts of Bayhydur 3100, 14 parts of chitosan quaternary ammonium salt, 0.6 part of tetrandrine, 0.6 part of tamoxifen, 70 parts of diphenylmethane diisocyanate (MDI), 2 parts of polysorbate (Tween), 2 parts of stannous octoate parts, 2 parts of tetrahydrofuran, and 100 parts of purified water. Wherein the degree of deacetylation of chitosan quaternary ammonium salt is 95%.

[0057] Preparation:

[0058] 1. Take Bayhydur 3100, tetrahydrofuran, chitosan quaternary ammonium salt, tetrandrine, tamoxifen, polysorbate (Tween), stannous octoate, purified water respectively in the proportioning by weight, at room temperature, 2000r / min After stirring for 5 min under the conditions.

[0059] ②Weigh and add the diphenylmethane diisocyanate (MDI) in the proportion by weight, continue to stir for 1min, put it into a foaming mold and keep it warm at 60°C for 40 ...

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Abstract

The invention relates to the technical field of medicines and particularly relates to a polyurethane foam dressing and a preparation method thereof. The polyurethane foam dressing is prepared from thefollowing raw materials: waterborne polyurethane prepolymers, water-soluble chitosan, tetrandrine, tamoxifen, isocyanate, a surfactant, a catalyst, a foaming agent and purified water. In the polyurethane foam dressing provided by the invention, the waterborne polyurethane prepolymers and the isocyanate are taken as the raw materials, the surfactant, the catalyst and the foaming agent are added, three active ingredients of the water-soluble chitosan, the tetrandrine and the tamoxifen are added, and all the ingredients have the synergistic interaction, so that the prepared polyurethane foam dressing has an obvious effect of wound healing, the wound healing speed is obviously improved, and the wound healing time is shortened to 5-6d.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a polyurethane foam dressing and a preparation method thereof. Background technique [0002] With the proposal of the "moist healing" theory of wounds and the development of biomaterials, new dressings, especially new polyurethane dressings, continue to emerge. Traditional wound dressings (such as gauze and cotton) have many disadvantages: they are easy to breed bacteria, and the wound exudate easily forms scabs with dry dermal tissue, which hinders epithelialization; at the same time, the wound is easy to adhere to the dressing, causing pain when the dressing is removed , causing secondary trauma. The new polyurethane dressing can keep the wound moist, control the water vapor transmission rate, and resist the invasion of bacteria; its spongy porous layered structure is conducive to the discharge of wound secretions and promote the healing of wound tissue; it feels comfortable ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/46A61L15/28A61L15/42A61L15/44A61L15/20C08J9/14C08J9/04C08G18/10C08G18/76
CPCA61L15/20A61L15/26A61L15/28A61L15/425A61L15/44A61L15/46A61L2300/204A61L2300/216A61L2300/232A61L2300/404A61L2300/412A61L2300/45C08G18/10C08J9/04C08J9/141C08J2375/04C08L75/04C08L5/08C08G18/7671
Inventor 张聪赵澎车七石刘少辉
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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