Micronano bioactive glass microsphere prepared by microemulsion technology and preparation method thereof

A bioactive glass, micro-nano technology, applied in glass manufacturing equipment, glass molding, manufacturing tools, etc., can solve the problems of uneven particle size distribution, particle agglomeration, poor dispersion, etc., and achieve the effect of solving serious agglomeration

Inactive Publication Date: 2018-05-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioactive glass prepared by a single sol-gel method still has the disadvantages of uncontrollable particle shape, severe particle agglomeration, and poor dispersion.
Some researchers have improved the dispersion and morphology...

Method used

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  • Micronano bioactive glass microsphere prepared by microemulsion technology and preparation method thereof
  • Micronano bioactive glass microsphere prepared by microemulsion technology and preparation method thereof
  • Micronano bioactive glass microsphere prepared by microemulsion technology and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A micronano bioactive glass microsphere prepared by microemulsion technology, the preparation method of which is as follows:

[0029] (1) Add 2g of cetyltrimethylammonium bromide and 15ml of cyclohexane to a mixed solution of 180ml of deionized water and 120ml of absolute ethanol in sequence, and stir evenly to form a microemulsion.

[0030] (2) Add 4.05ml tetraethyl orthosilicate, 1.5ml ammonia water (25wt%), 0.42ml triethyl phosphate and 2.574g calcium nitrate tetrahydrate to the microemulsion obtained in step (1) in sequence, and stir evenly to obtain Bioactive glass gel solution.

[0031] (3) Centrifuge the bioactive glass gel solution obtained in step (2), wash to obtain a wet gel precipitate, and then place the wet gel precipitate in an oven at 60°C to dry for 2 days to obtain a bioactive glass Gel powder.

[0032] (4) Heat-treating the bioactive glass gel powder in a high-temperature furnace at 650° C. for 3 hours to obtain micro-nano bioactive glass microspher...

Embodiment 2

[0035] A micronano bioactive glass microsphere prepared by microemulsion technology, the preparation method of which is as follows:

[0036] (1) Add 1g of cetyltrimethylammonium bromide and 15ml of cyclohexane to a mixed solution of 180ml of deionized water and 60ml of absolute ethanol in sequence, and stir evenly to form a microemulsion.

[0037] (2) Add 4.05ml tetraethyl orthosilicate, 1ml ammonia water (25wt%), 0.42ml triethyl phosphate and 2.574g calcium nitrate tetrahydrate to the microemulsion obtained in step (1) in sequence, stir well to obtain biological Active glass gel solution.

[0038] (3) Centrifuge the bioactive glass gel solution obtained in step (2), wash to obtain a wet gel precipitate, and then place the wet gel precipitate in an oven at 50°C to dry for 2 days to obtain bioactive glass Gel powder.

[0039] (4) Heat-treating the bioactive glass gel powder in a high-temperature furnace at 620° C. for 3 hours to obtain micro-nano bioactive glass microspheres....

Embodiment 3

[0042] A micronano bioactive glass microsphere prepared by microemulsion technology, the preparation method of which is as follows:

[0043] (1) Add 3.5g of cetyltrimethylammonium bromide and 30ml of cyclohexane to a mixed solution of 180ml of deionized water and 150ml of absolute ethanol in sequence, and stir evenly to form a microemulsion.

[0044] (2) Add 8.1ml tetraethyl orthosilicate, 3ml ammonia water (25wt%), 0.84ml triethyl phosphate and 5.148g calcium nitrate tetrahydrate to the microemulsion obtained in step (1) in sequence, stir evenly to obtain biological Active glass gel solution.

[0045] (3) Centrifuge the bioactive glass gel solution obtained in step (2), wash to obtain a wet gel precipitate, and then place the wet gel precipitate in an oven at 80°C to dry for 1 day to obtain a bioactive glass Gel powder.

[0046] (4) Heat-treating the bioactive glass gel powder in a high-temperature furnace at 700° C. for 2 hours to obtain micro-nano bioactive glass microsph...

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Abstract

The invention discloses a micronano bioactive glass microsphere prepared by the microemulsion technology and a preparation method thereof. The preparation method of the micronano bioactive glass microsphere includes the following steps that 1, water, ethanol, an organic solvent and a surfactant are used for preparing a mixed solution, tetraethyl orthosilicate, a catalyst, triethyl phosphate and calcium nitrate are sequentially added, and the mixture is stirred evenly to obtain a bioactive glass gel solution; 2, the bioactive glass gel solution is centrifuged and cleaned, a wet gel precipitateis obtained, and the wet gel precipitate is placed in a drying oven for drying, and bioactive glass gel powder is obtained; 3, the bioactive glass gel powder is placed in a high-temperature furnace for heat treatment, and the micronano bioactive glass microsphere is obtained. The prepared micronano bioactive glass microsphere has the advantages of being good in dispersion and uniform in particle size distribution, and is a novel bone and dental regeneration and repair material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a micro-nano bioactive glass microsphere prepared by microemulsion technology and a preparation method thereof. Background technique [0002] In the early 1970s, Professor Hench obtained 45S5 (mass percentage: 45%SiO 2 -24.5%Na 2 O-24.5%CaO-6%P 2 o 5 ) Bioactive glass, which has good biocompatibility and bioactivity, has been used in clinical bone, tooth and skin tissue repair. However, the preparation process of the melting method has harsh preparation conditions (preparation at a high temperature of about 1400 degrees), high energy consumption, and easily leads to material impurity ion doping, and the surface of the material particles is dense and the specific surface area is small, which is not conducive to ion release and in vivo degradation. [0003] In recent years, the bioactive glass prepared by the sol-gel method provides a good preparation for the preparation of ...

Claims

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Application Information

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IPC IPC(8): C03B19/10C03B8/02
CPCC03B19/1065
Inventor 陈晓峰王聿栋孙璐瑶莫云飞陈雪颖罗曼
Owner SOUTH CHINA UNIV OF TECH
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