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A kind of carboxylic acid type magnetic nanoparticle and its application obtained by PEG regulation

A magnetic nanoparticle, carboxylic acid type technology, applied in the direction of magnetic materials, magnetic objects, inorganic materials, etc., can solve the problems of easy agglomeration, unable to form a stable dispersion system, and achieve uniform particle size distribution, low remanence, large The effect of ion exchange capacity

Inactive Publication Date: 2020-05-05
SHANDONG NORMAL UNIV
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  • Description
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Problems solved by technology

Co-precipitation method is the simplest and most commonly used method at present, but the magnetic ferroferric oxide nanoparticles prepared by it have defects in application: magnetic ferric oxide nanoparticles prepared by co-precipitation method, due to the high specificity of magnetic nanoparticles Surface area, high specific surface energy, and the dipole moment effect of particle anisotropy make it easy to agglomerate, Fe 3 o 4 easily oxidized to γ-Fe 2 o 3 , resulting in aggregation and precipitation of particles, unable to form a stable dispersion system

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  • A kind of carboxylic acid type magnetic nanoparticle and its application obtained by PEG regulation
  • A kind of carboxylic acid type magnetic nanoparticle and its application obtained by PEG regulation
  • A kind of carboxylic acid type magnetic nanoparticle and its application obtained by PEG regulation

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preparation example Construction

[0029] In a second aspect, the present invention provides a method for preparing carboxylic acid-type magnetic nanoparticles regulated by polyethylene glycol, comprising the following steps:

[0030] (1) the preparation of the nano ferric oxide that polyethylene glycol participates in;

[0031] (2) modification of nano ferric oxide;

[0032] (3) The carboxylic acid is covalently coupled with the modified nano-scale ferric oxide.

[0033] In the preferred technical solution of the present invention, in step (1): the ratio of the amount of the ferrous salt to the ferric salt is 2:1.1; the concentration of ammonia water used as the precipitant is 1.5M.

[0034] In the preferred technical scheme of the present invention, in step (2): the nano ferric oxide and Na 2 SiO 3 9H 2 O after mixing according to the mass ratio of 1:6, add deionized water and heat to 85-90°C in a water bath under the protection of nitrogen, dropwise add 2M hydrochloric acid solution until the pH value of...

Embodiment 1

[0041] Embodiment 1 A kind of preparation method of the carboxylic acid type magnetic nanoparticle that is regulated by polyethylene glycol

[0042] The preparation method of the carboxylic acid type magnetic nanoparticles obtained by the regulation of polyethylene glycol comprises the following steps:

[0043] (1) Preparation of nano-iron ferric oxide participated in by polyethylene glycol: measure 12ml of 0.17M FeCl 3 ·6H 2 O, 10ml 0.1M FeCl 2 4H 2 0, put in the four-necked flask of 500ml, add the 50% molecular weight of 20ml and be the PEG solution of 1000, stir and be made into mixed solution; 2 Under protection, heat it to 85-90°C with a water bath, and add 1.5M ammonia water drop by drop during the process of strong electric stirring. The mixed solution gradually changes from orange-yellow to orange-red, and finally turns into black. When the solid is formed, when the pH rises to 8-9, continue to drop 10ml of 1.5M ammonia water to fully hydrolyze it, stop stirring an...

Embodiment 2

[0046] Embodiment 2 A kind of preparation method of the carboxylic acid type magnetic nanoparticle that is regulated by polyethylene glycol

[0047] The preparation method of the carboxylic acid type magnetic nanoparticles obtained by the regulation of polyethylene glycol comprises the following steps:

[0048] (1) Preparation of nano-iron ferric oxide participated in by polyethylene glycol: measure 12ml of 0.17M FeCl 3 ·6H 2 O, 10ml 0.1M FeCl 2 4H 2 0, put in the four-necked flask of 500ml, add the 50% molecular weight of 20ml and be the PEG solution of 1500, stir and be made into mixed solution; 2 Under protection, heat it to 85-90°C with a water bath, and add 1.5M ammonia water drop by drop during the process of strong electric stirring. The mixed solution gradually changes from orange-yellow to orange-red, and finally turns into black. When the solid is formed, when the pH rises to 8-9, continue to drop 10ml of 1.5M ammonia water to fully hydrolyze it, stop stirring an...

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Abstract

The invention belongs to the technical field of preparation of functional nano materials, and relates to a carboxylic acid type magnetic nanoparticle prepared through PEG control and application of the nanoparticle. Nano ferroferric oxide is prepared through a co-precipitation method, in order to reduce the agglomeration of the ferroferric oxide nanoparticles, polyethylene glycol with the molecular weight of 400-2000 is added into a system for adjusting the viscosity of the system when the ferroferric oxide nanoparticles are prepared, the prepared nano magnetic ferroferric oxide uniform in particle is good in magnetic property, oxidation resistance and dispersibility; through combination of chemical modification, the carboxylic acid type magnetic nanoparticle good in dispersibility is prepared. The carboxylic acid typemagnetic nanoparticle can be used for the cancer targeted magnetic-field treatment and the removal of heavy metal ions.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional nanometer materials, and relates to a carboxylic acid type magnetic nanometer particle regulated by PEG and its application. Background technique [0002] As an important nanomaterial, magnetic nanoparticles have broad application prospects in the fields of information technology and biomedicine because of their special magnetic properties. Magnetic Fe 3 o 4 As a kind of magnetic nanomaterials, nanomaterials are widely used in biology, medicine, catalysis, separation, environmental protection, sewage treatment and other fields due to their good magnetic properties and surface activity. [0003] Nano Fe 3 o 4 There are many preparation methods, such as: co-precipitation method, sol-gel method, microemulsion method, hydrothermal method, oxidation precipitation method and so on. The co-precipitation method is currently the simplest and most commonly used method, but the magneti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/36H01F41/00C01G49/08
CPCC01G49/08C01P2002/82C01P2002/88C01P2004/04C01P2004/62C01P2004/64C01P2006/42H01F1/0018H01F1/0045H01F1/344H01F1/36H01F41/00
Inventor 张其坤姜琳靖孙明雪江照艳张新虹刘小娟
Owner SHANDONG NORMAL UNIV
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