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Preparation method of beta-cyclodextrin microsphere for rhizoma acori graminei volatile oil

A technology of cyclodextrin and volatile oil, which is applied in skin care preparations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve bad smell, irritation, and insoluble volatile oil of Acorus calamus, etc. problem, achieve the effect of reducing irritation, increasing water solubility, and broadening application ideas

Inactive Publication Date: 2018-06-05
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing β-cyclodextrin microspheres of Acorus volatile oil, which solves the problem that the volatile oil of Acorus calamus is difficult to dissolve in a hydrophilic solution and has bad smell and irritation

Method used

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  • Preparation method of beta-cyclodextrin microsphere for rhizoma acori graminei volatile oil
  • Preparation method of beta-cyclodextrin microsphere for rhizoma acori graminei volatile oil
  • Preparation method of beta-cyclodextrin microsphere for rhizoma acori graminei volatile oil

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preparation example Construction

[0034] A kind of preparation method of the volatile oil β-cyclodextrin microspheres of Acorus calamus of the present invention comprises the following steps:

[0035] Step 1, preparation of β-cyclodextrin microspheres

[0036] Step 1.1, add β-cyclodextrin to the sodium hydroxide aqueous solution with a mass concentration of 0.1-1.0g / mL, stir at 30-40°C until completely dissolved, and the β-cyclodextrin in each milliliter of sodium hydroxide aqueous solution The mass is 0.1-1.0g;

[0037] Step 1.2, add epichlorohydrin to the solution in step 1.1, stir for 1-5h at a constant temperature of 20-60°C and a rotation speed of 500-1000r / min, and add kerosene at the same time, the mass ratio of epichlorohydrin to kerosene is 3:2- 2:1; react for 6-24 hours when the temperature is raised to 20-60°C, then vacuum filter, wash, dry, and grind in sequence to obtain β-cyclodextrin microspheres;

[0038] Wherein kerosene is the kerosene containing emulsifier Span-80, Tween-20, wherein the ma...

Embodiment 1

[0044] (1) Preparation of β-cyclodextrin microspheres

[0045] Add 6g of β-cyclodextrin into 10mL of sodium hydroxide aqueous solution with a mass concentration of 0.4g / mL, stir at a constant temperature of 30°C until completely dissolved; then control the rotation speed at 750r / min, stir at 30°C for 1.5h, and add while stirring Add epichlorohydrin and kerosene at the same time, the mass ratio of epichlorohydrin to kerosene is 3:2; react for 6 hours when the temperature is raised to 60°C, then vacuum filter, wash, dry, and grind in sequence to obtain β-cyclodextrin microspheres;

[0046] Wherein kerosene is the kerosene containing emulsifier Span-80, Tween-20, wherein the mass ratio of emulsifier Span-80 and emulsifier Tween-20 is 3:1;

[0047] When cleaning, use dilute hydrochloric acid, absolute ethanol, distilled water, and acetone in sequence; the drying temperature is 60°C and the drying time is 24 hours.

[0048] (2) Obtaining Acorus volatile oil β-cyclodextrin microsph...

Embodiment 2

[0053] (1) Preparation of β-cyclodextrin microspheres

[0054] Add 1 g of β-cyclodextrin to 10 mL of aqueous sodium hydroxide solution with a mass concentration of 0.1 g / mL, stir at a constant temperature of 35 °C until completely dissolved; then control the rotation speed at 700 r / min, stir at 35 °C for 3 h, and add cyclodextrin while stirring Add oxychloropropane and kerosene at the same time, the mass ratio of epichlorohydrin to kerosene is 2:1; react for 24 hours when the temperature is raised to 40°C, then vacuum filter, wash, dry and grind in sequence to obtain β-cyclodextrin microspheres;

[0055] Wherein kerosene is the kerosene containing emulsifier Span-80, Tween-20, wherein the mass ratio of emulsifier Span-80 and emulsifier Tween-20 is 3:1;

[0056] When cleaning, use dilute hydrochloric acid, absolute ethanol, distilled water, and acetone in sequence; the drying temperature is 40°C and the drying time is 48h.

[0057] (2) Obtaining Acorus volatile oil β-cyclodext...

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Abstract

The invention discloses a preparation method of a beta-cyclodextrin microsphere for rhizoma acori graminei volatile oil. The preparation method comprises steps of firstly preparing the beta-cyclodextrin microsphere, adding the beta-cyclodextrin microsphere into distilled water, heating for dissolving to form a saturated solution, cooling, adding the rhizoma acori graminei volatile oil, carrying out sealing and ultrasonic concussion, cooling, carrying out suction filtration, washing with petroleum ether, and drying. According to the preparation method, the water solubility of the rhizoma acorigraminei volatile oil can be obviously increased, the bad foul smell of the rhizoma acori graminei volatile oil can be covered, the irritation of the rhizoma acori graminei volatile oil can be alleviated, and the rhizoma acori graminei volatile oil can be taken as a raw material to be added into cosmetics and drugs, so that the problem that the rhizoma acori graminei volatile oil is poor in watersolubility, has bad smell and is high in irritation are solved, the application range of the rhizoma acori graminei volatile oil is greatly expanded, and an application thought of the rhizoma acori graminei volatile oil in the fields of foods, medicines and cosmetics is broadened; and the preparation method has important practical significances.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of microspheres, and in particular relates to a method for preparing β-cyclodextrin microspheres of Acorus volatile oil. Background technique [0002] The traditional Chinese medicine Shichangpu is the rhizome of the Araceae plant Shichangpu, which has the effect of rejuvenating and refreshing. It contains volatile components α-asarona (α-asarona), β-asarone (β-asarone), methyl eugenol (methy equens) and other substances. Modern pharmacological studies have shown that the volatile oil of Shichangpu has a strong sedative and hypnotic effect, and it is widely used clinically to treat coma, epilepsy, amnesia and dementia. However, because the volatile oil of Acorus calamus is insoluble in water and irritating to skin and mucous membranes, it is difficult to apply it in the preparation process, especially when it is prepared into solid preparations such as tablets, powders, and capsules. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/50A61K47/69A61K8/92A61K8/73A61K8/11A61Q19/00
CPCA61K8/11A61K8/738A61K8/922A61K36/888A61K2800/10A61K2800/56A61Q19/00
Inventor 张彦张寒李伟泽罗国平唐一梅郑蕾申旭霁汪兴军
Owner XIAN MEDICAL UNIV
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