Targeted phase change type multi-mode development nano contrast medium and preparation method thereof

A nano-contrast agent, phase-change technology, applied in general/multifunctional contrast agents, echo/ultrasound imaging agents, pharmaceutical formulations, etc., can solve the problem of not being able to break through the limitations of a single image examination, and achieve uniform size and dispersion. Good results

Inactive Publication Date: 2018-06-05
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although enhancers have provided assistance in the diagnosis and treatment of diseases, they still cannot break through the limitations of a single imaging examination

Method used

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  • Targeted phase change type multi-mode development nano contrast medium and preparation method thereof
  • Targeted phase change type multi-mode development nano contrast medium and preparation method thereof
  • Targeted phase change type multi-mode development nano contrast medium and preparation method thereof

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Experimental program
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Embodiment Construction

[0031] 1. The targeted phase-change multimodal imaging nano-contrast agent (FA / Fe 3 o 4 / PFP / HCPT@Lipid), its specific preparation method is:

[0032] 1), Dissolution: HSPC-hydrogenated soybean lecithin (Avanti, USA), DSPE (PEG2000) Folate-phospholipid PEG folic acid (Chongqing Pu Nuowei Biotechnology Co., Ltd.), DPPG-1,2-palmitoylphosphatidylglycerol ( Avanti, USA), CHOL-cholesterol (Sangon Bioengineering (Shanghai) Co., Ltd.), and HCPT were weighed in a total of 22 mg according to the mass ratio of 10:4:3:3:2 and added to a round bottom flask. At the same time, 100 μL oleic acid oxidation Iron nanoparticles OA-Fe 3 o 4 (25mg / mL), measure 10mL of chloroform and 10mL of methanol into a round bottom flask, close the mouth of the round bottom flask, place in 50°C water and heat until fully dissolved.

[0033] 2), rotary evaporation: after dissolving for 20min, fix the round bottom flask on a rotary evaporator (temperature: 50°C) to reduce

[0034] Pressure rotary evaporation ...

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Abstract

The invention discloses a targeted phase change type multi-mode development nano contrast medium. The contrast medium comprises a lipid shell membrane, wherein the lipid shell membrane is loaded witholeic acid ferric oxide nano particles and a drug HCPT, and folic acid is modified on the lipid shell membrane. The invention aims at providing the contrast medium which can achieve multi-mode development and accurate treatment on tumors by carrying out liquid-gas phase change, enhancing development and releasing the drug under the low-intensity focused ultrasound action.

Description

technical field [0001] The invention relates to the field of ultrasonic imaging, in particular to a targeted phase-change multimodal imaging nano-contrast agent and a preparation method thereof. Background technique [0002] Traditional single image examination methods have their own shortcomings, and there are certain limitations in application. However, multiple image fusion imaging allows various image examination methods to complement each other and complement each other, which can improve the accuracy of diagnosis. Multifunctional contrast agents that combine two or more imaging modalities are research hotspots in modern molecular imaging. In addition to the function of imaging, multimodal contrast agents can also be loaded with drugs, genes, etc., to achieve controllable targeted therapy under the guidance and monitoring of images. Therefore, the multimodal multifunctional contrast agent can integrate imaging and treatment, laying a solid foundation for early and accu...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K49/00A61K49/10A61K49/18A61K31/4745A61K9/50A61P35/00
CPCA61K49/225A61K9/5015A61K31/4745A61K49/0002A61K49/10A61K49/1821
Inventor 刘建新王志刚李攀冉海涛郑元义郝兰曹阳
Owner CHONGQING MEDICAL UNIVERSITY
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