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External preparation for skin eczema and preparation method of external preparation

A technology for skin eczema and external preparations, which is applied to the field of skin eczema external preparations and their preparation, can solve the problems of various itching, lack of quick relief of infection, lack of perfect scientific preparation process, lack of transdermal absorption effect, etc. , to achieve good synergistic effect, good transdermal absorption effect, and the effect of enhancing adhesion effect

Inactive Publication Date: 2018-06-15
亳州市君臣佐使药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the present invention provides an external preparation for skin eczema and its preparation method, which solves the problem that it does not have good transdermal absorption effect, and the various itches and infections caused by skin eczema cannot be quickly resolved. To alleviate the problem that the preparation process is relatively simple and there is no perfect scientific preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0032] 1) Preparation of traditional Chinese medicine extract: 60g of Jiuliguang, 60g of Cortex Phellodendri, 30g of Coptis chinensis, 60g of Scutellaria baicalensis, 60g of raw rhubarb, 60g of rehmannia root, 30g of saxifrage, 60g of sophora flavescens, 30g of raw licorice, 30g of Daqingye, and 30g of red peony , Dan Cortex 30g, Gentiana 30g, Brucea javanica 30g and Fructus Cnidii 30g were placed in 10 liters of 50% glacial acetic acid aqueous solution, normal temperature ultrasonic extraction for 48 hours, filtered, and finally settled to 15 liters with 50% glacial acetic acid aqueous solution for later use ;

[0033] 2) Preparation of carboxyamino chitosan solution: at normal temperature, mix 0.75kg carboxyamino chitosan powder with 750ml pure water, and stir evenly, then slowly add 500ml of 50% acetic acid solution under continuous stirring, and stir until After completely dissolving, dilute to 2.5L with water and set aside;

[0034] 3) Menthyl p-methoxycinnamate preparat...

preparation Embodiment 2

[0037]1) Preparation of traditional Chinese medicine extract: 60g of Jiuliguang, 60g of Cortex Phellodendri, 30g of Coptis chinensis, 60g of Scutellaria baicalensis, 60g of raw rhubarb, 60g of rehmannia root, 30g of saxifrage, 60g of sophora flavescens, 30g of raw licorice, 30g of Daqingye, and 30g of red peony , Dan Cortex 30g, Gentiana 30g, Brucea javanica 30g and Fructus Cnidii 30g were placed in 10 liters of 50% glacial acetic acid aqueous solution, normal temperature ultrasonic extraction for 48 hours, filtered, and finally settled to 15 liters with 50% glacial acetic acid aqueous solution for later use ;

[0038] 2) Preparation of carboxyamino chitosan solution: at normal temperature, mix 0.75kg carboxyamino chitosan powder with 750ml pure water, and stir evenly, then slowly add 500ml of 50% acetic acid solution under continuous stirring, and stir until After complete dissolution, dilute to 2.5L with water and set aside;

[0039] 3) Menthyl p-methoxycinnamate preparatio...

preparation Embodiment 3

[0042] 1) Preparation of traditional Chinese medicine extract: 60g of Jiuliguang, 60g of Cortex Phellodendri, 30g of Coptis chinensis, 60g of Scutellaria baicalensis, 60g of raw rhubarb, 60g of rehmannia root, 30g of saxifrage, 60g of sophora flavescens, 30g of raw licorice, 30g of Daqingye, and 30g of red peony , Dan Cortex 30g, Gentiana 30g, Brucea javanica 30g and Fructus Cnidii 30g were placed in 10 liters of 50% glacial acetic acid aqueous solution, normal temperature ultrasonic extraction for 48 hours, filtered, and finally settled to 15 liters with 50% glacial acetic acid aqueous solution for later use ;

[0043] 2) Preparation of carboxyamino chitosan solution: at normal temperature, mix 0.75kg carboxyamino chitosan powder with 750ml pure water, and stir evenly, then slowly add 500ml of 50% acetic acid solution under continuous stirring, and stir until After complete dissolution, dilute to 2.5L with water and set aside;

[0044] 3) Menthyl p-methoxycinnamate preparati...

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Abstract

The invention discloses an external preparation for skin eczema. The external preparation is prepared from 0.1%-0.5% of menthyl p-methoxy cinnamic acid, 0.5%-5% of carboxyamino chitosan, 50%-80% of traditional Chinese medicine extract and the balance purified water. The preparation method of the preparation comprises the following steps that 1, the traditional Chinese medicine extract is prepared;2, a carboxyamino chitosan solution is prepared; 3, the menthyl p-methoxy cinnamic acid is prepared; 4, a finished product is obtained. The external preparation prepared through the method for the skin eczema has the good percutaneous absorption effect, the traditional Chinese medicine ingredients and the menthyl p-methoxy cinnamic acid and the carboxyamino chitosan have the good synergy effect,the traditional Chinese medicine active ingredients have the good percutaneous absorption effect, various pruritus and infections caused by the skin eczema can be rapidly relieved, and meanwhile the defects that traditional Chinese medicine water extract contaminates clothes, the curative effect is poor, and precipitation is separated out are avoided, preservative does not need to be added for thepreparation, it is guaranteed that liquid medicine containing the traditional Chinese medicine ingredients does not mildew, and the phenomena that due to a commercial aseptic operation, the characteristic curative effect changes, and the cost is lower are avoided.

Description

technical field [0001] The invention relates to the field of medical medicine and preparation technology, in particular to an external preparation for skin eczema and a preparation method thereof. Background technique [0002] Eczema is a skin inflammatory reaction with severe itching caused by various internal and external factors. Divided into acute, subacute and chronic three stages. In the acute phase, it tends to exudate, while in the chronic phase, it is infiltrating and hypertrophic. Some patients directly show chronic eczema. The skin lesions are characterized by pleomorphism, symmetry, itching, and recurrent attacks. [0003] The pathogenesis of skin eczema is very complicated, and it can be simply divided into internal factors and external factors. It is difficult to distinguish between the primary and secondary factors, and they are usually related to each other and act synergistically. External factors such as chemical agents, cosmetics, animal toxins, fish a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K36/804A61K9/12A61K47/36A61P17/00A61P17/04A61K31/216
CPCA61K9/0014A61K9/12A61K31/216A61K36/185A61K36/195A61K36/234A61K36/28A61K36/282A61K36/315A61K36/484A61K36/489A61K36/515A61K36/539A61K36/65A61K36/704A61K36/708A61K36/71A61K36/718A61K36/756A61K36/804A61K36/855A61K47/36A61K2236/333A61K2300/00
Inventor 熊良钟熊清爵韩长峰陈敏王振刘永学阮志燕苏新国肖鹏
Owner 亳州市君臣佐使药业有限公司
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