Composite sulfadiazine-trimethoprim nanoparticle preparation and preparation method thereof

A technology of sulfadiazine and trimethoprim, which is applied in the field of compound sulfadiazine-trimethoprim nanoparticle preparation and its preparation, can solve the problems of affecting the stability of the suspension and adding more substances, and achieve convenience and popularization, The effect of low production cost and simple preparation process

Inactive Publication Date: 2018-06-29
HUNAN XIANGYIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method adds many substances, and the interaction between excipients will easily affect the stability of the suspension.

Method used

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  • Composite sulfadiazine-trimethoprim nanoparticle preparation and preparation method thereof
  • Composite sulfadiazine-trimethoprim nanoparticle preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The raw material formula is as follows:

[0024] Sulfadiazine 5.0 g

[0025] Trimethoprim 1.0 g

[0026] Hydroxypropyl methylcellulose 45.0 g

[0027] 1,2-Propanediol 15.0 g

[0028] The specific operation steps are:

[0029] (1) The raw materials are taken according to the formula, and the solid materials are pulverized by a nano-ceramic sand mill to obtain nanoparticles of each material with a particle size of ≤1000 nm;

[0030] (2) Under stirring, dissolve sulfadiazine in the co-surfactant according to the solid-to-liquid ratio of 1:3 to obtain a solution;

[0031] (3) Dissolving trimethoprim in the solution of step (2) under stirring;

[0032] (4) Disperse hydroxypropyl methylcellulose in the solution of step (3), stir for 30 min, and then sonicate for 60 min;

[0033] (5) Add the mixed solution in step (4) into the ball mill, start with exhaust speed of 1500 rpm for 30 minutes, increase the grinding speed to 5000 rpm after 30 minutes, circulate condensed wate...

Embodiment 2

[0036] The raw material formula is as follows:

[0037] Sulfadiazine 10.0 g

[0038] Trimethoprim 1.0 g

[0039] Hydroxypropyl methylcellulose 45.0 g

[0040] Hydroxypropyl Cellulose 45.0 g

[0041] 1,2-Propanediol 30.0 g

[0042] The specific operation steps are:

[0043] (1) The raw materials are taken according to the formula, and the solid materials are pulverized by a nano-ceramic sand mill to obtain nanoparticles of each material with a particle size of ≤1000 nm;

[0044] (2) Under stirring, dissolve sulfadiazine in the co-surfactant according to the solid-to-liquid ratio of 1:3 to obtain a solution;

[0045] (3) Dissolving trimethoprim in the solution of step (2) under stirring;

[0046] (4) Disperse hydroxypropyl methylcellulose and hydroxypropyl cellulose in the solution of step (3), stir for 30 minutes, and then sonicate for 60 minutes;

[0047] (5) Add the mixed solution in step (4) into the ball mill, start with exhaust speed of 1500 rpm for 30 minutes, incr...

Embodiment 3

[0050] The raw material formula is as follows:

[0051] Sulfadiazine 5.0 g

[0052] Trimethoprim 1.0 g

[0053] Copovidone 45.0 g

[0054] Macrogol 4000 10.0g

[0055] Hydroxypropyl methylcellulose 10.0g

[0056] Ethanol 15.0 g

[0057] The specific operation steps are:

[0058] (1) The raw materials are taken according to the formula, and the solid materials are pulverized by a nano-ceramic sand mill to obtain nanoparticles of each material with a particle size of ≤1000 nm;

[0059] (2) Under stirring, dissolve sulfadiazine in the co-surfactant according to the solid-to-liquid ratio of 1:3 to obtain a solution;

[0060] (3) Dissolving trimethoprim in the solution of step (2) under stirring;

[0061] (4) Disperse copovidone, polyethylene glycol 4000 and hydroxypropyl methylcellulose in the solution of step (3), stir for 30 min, and then sonicate for 60 min;

[0062] (5) Add the mixed solution in step (4) into the ball mill, start with exhaust speed of 1500 rpm for 30 m...

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Abstract

The invention discloses a composite sulfadiazine-trimethoprim nanoparticle preparation. The particle size of the nanoparticle preparation ranges from 1 to 100 nm. The nanoparticle preparation is prepared from sulfadiazine, trimethoprim, a macromolecule substance and a cosurfactant. The composite preparation is a nanoparticle preparation which is good in stability and high in solubility; the sulfadiazine and the trimethoprim in the preparation have remarkable synergetic effects, and with the combination of the two components, the antibacterial function of the preparation can be greatly improved, in addition, anti-medicine strains can be reduced; the composite nanoparticle preparation has the advantages of safety, high efficiency, wide spectrums, low drug resistance, and the like.

Description

technical field [0001] The invention belongs to the technical field of antibacterial drugs, and in particular relates to a compound sulfadiazine-trimethoprim nanoparticle preparation and a preparation method thereof. Background technique [0002] Antibacterial drugs have the advantages of fast onset of action and low production cost in the treatment of infectious diseases, making them widely used clinically. However, the limitations of traditional dosage forms and the gradual increase of drug resistance make the treatment cost increase and the treatment effect decrease. For this reason, in clinical practice, two or more antibacterial drugs are often used in combination to achieve the purpose of expanding the antibacterial spectrum, enhancing the curative effect, reducing the dosage, reducing or avoiding toxic and side effects, and reducing or delaying the emergence of drug-resistant strains. [0003] Sulfadiazine (SD), also known as p-amino-N-2-pyrimidinylbenzenesulfonami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/63A61K31/505A61K9/51A61K47/32A61K47/38A61K47/10A61P31/04
CPCA61K31/63A61K9/5138A61K9/5146A61K9/5161A61K31/505A61K2300/00
Inventor 帅放文王向峰章家伟
Owner HUNAN XIANGYIKANG PHARMA
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