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Novel nano gold composite antibacterial agent and preparation method thereof

A composite antibacterial agent and nano-gold technology, which can be used in antifungal agents, antibacterial agents, microcapsules, etc., can solve problems such as low price, and achieve the effect of significant bacteriostatic effect, small nanoparticles, and controllable size.

Inactive Publication Date: 2018-06-29
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its abuse is getting worse because of its low price

Method used

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  • Novel nano gold composite antibacterial agent and preparation method thereof
  • Novel nano gold composite antibacterial agent and preparation method thereof
  • Novel nano gold composite antibacterial agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Dissolve 1mg of chloroauric acid in 10mL of water, stir at 4°C, add 1mg of polyvinylpyrrolidone during stirring, after stirring for 0.5h, add 1mg of gentamicin sulfate, stir for 0.1h, then add 100μL of boron After fully stirring the sodium hydride solution for 3 hours, dialyze the resulting mixed solution for 4 days to obtain the nano-gold composite antibacterial agent.

[0030] The nano-gold composite antibacterial agent prepared in embodiment 1 is tested for performance, specifically as follows:

[0031] 1) Transmission electron microscope (TEM) test

[0032] TEM photo of nano gold composite antibacterial agent, such as figure 1 As shown, it can be observed that the particle size of the nano-gold composite antibacterial agent is between 1-10nm.

[0033] 2) Dynamic light scattering (DLS) test

[0034] The particle size columnar distribution diagram of nano-gold sol and nano-gold composite antibacterial agent, such as figure 2 , 3 As shown, it can be observed that...

Embodiment 2

[0042] Dissolve 1.5mg of chloroauric acid in 10mL of water, stir at 0°C, add 1mg of polyvinylpyrrolidone during stirring, after stirring for 1h, add 1mg of gentamicin sulfate, stir for 0.2h, then add 100μL of boron Sodium hydride solution, fully stirred for 4 hours, and the resulting mixed solution was dialyzed for 3 days to obtain a nano-gold composite antibacterial agent.

Embodiment 3

[0044] Dissolve 1.5mg of chloroauric acid in 10mL of water, stir at 4°C, add 1.5mg of polyvinylpyrrolidone during the stirring process, stir for 1.5h, add 1.5mg of gentamicin sulfate, stir for 0.4h, Add 150 μL of sodium borohydride solution, stir thoroughly for 5 hours, and dialyze the resulting mixed solution for 5 days to obtain a nano-gold composite antibacterial agent.

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Abstract

The invention discloses a novel nano gold composite antibacterial agent and a preparation method thereof. The novel nano gold composite antibacterial agent is gentamycin sulfate loaded nano gold particles. The preparation method comprises following steps: adding polyvinylpyrrolidone into chloroauric acid, evenly stirring, adding gentamycin sulfate, then adding a sodium borohydride solution to reduce chloroauric acid and load gentamycin sulfate, and removing unloaded gentamycin sulfate in the solution through dialysis to obtain the nano gold composite antibacterial agent. The nano gold composite antibacterial agent is prepared by a one-step reduction method, the technical process is simple, the method is green and environmentally friendly, moreover, the size of the prepared nano gold composite antibacterial agent is controllable, the particle size distribution is narrow, the average particle size is 4.7 nm, the nano particles are small, and agglomeration is difficult to happen. Throughan electrostatic adsorption effect, gentamycin sulfate is loaded on nano gold, and the antibacterial agent has a broad-spectrum antibacterial property and a synergetic antibacterial property and can well inhibit Gram-positive bacteria, Gram-negative bacteria, and fungi.

Description

technical field [0001] The invention relates to the technical field of antibacterial and bactericide agents, in particular to a novel nano-gold composite antibacterial agent and a preparation method thereof. Background technique [0002] In recent years, with the abuse of antibiotics, many bacteria have developed drug resistance. Conventional antibiotics have a single target and cannot effectively kill "super bacteria", which greatly increases the mortality of infected people. Therefore, it is necessary to develop nano-antibacterial agents to fight against superbugs, that is, the active center small molecules of antibacterial agents are loaded on nanoparticles, and the multivalent effect and membrane-penetrating effect of nanoparticles are used to exert antibacterial effects. However, this kind of nano antibacterial agent is difficult to induce bacterial drug resistance because its bactericidal mechanism is to sterilize bacteria through multiple actions. [0003] At present...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K31/7036A61K9/51A61K47/02A61K47/32A61P31/04A61P31/10
CPCA61K9/5115A61K9/5138A61K31/7036A61K33/24A61K2300/00
Inventor 邵伟叶姗江蕾苏晨吴祭民张蕤
Owner NANJING FORESTRY UNIV
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