Small animal smoke inhalation microenvironment preparation system

Abstract

The invention discloses a small animal smoke inhalation microenvironment preparation system, which belongs to the technical field of biological and environmental medicine research and scientific research instruments, and is used for simulating a respiratory inhalation microenvironment, and preparing small animal respiratory system disease models including a chronic obstructive pulmonary disease model, an asthma model, a bronchial inflammation model, a PM2.5 inhalation injury model and a model antigen or drug inhalation injury model. The small animal smoke inhalation microenvironment preparation system is characterized by comprising a microenvironment box body, a main control box, a model preparation device, and an air exhaust device. During operation, smoke or air containing PM2.5 or containing antigen (or drug) generated in the model preparation device is injected into the microenvironment box body by means of an injection pump, real-time monitoring is realized by means of a measurement and control circuit, and a microenvironment in the microenvironment box body is fed back and regulated in real time according to a set limit value. The inhalation microenvironment prepared by the small animal smoke inhalation microenvironment preparation system has the advantages of precise index control, high stability, high repeatability and the like, is multi-purpose, and effectively saves the experimental costs of the instrument and equipment.

Description

Technical field [0001] The patent of the invention relates to a small animal smoke inhalation microenvironment preparation system, which is used to simulate the breathing and inhalation microenvironment of small animals to prepare small animal chronic obstructive pulmonary disease (COPD), asthma, bronchial inflammation, PM2.5 inhalation airway damage , Model drug or antigen atomized inhalation triggers a respiratory system disease model; and can be used to study the efficacy of therapeutic drug atomized inhalation, belonging to the technical field of biological and medical scientific research instruments. Background technique [0002] Respiratory diseases (mainly including asthma and COPD) have become one of the top ten causes of death in China. Among them, as far as COPD is concerned, the number of deaths due to it is as high as 1.28 million every year. Moreover, affected by factors such as increasingly serious atmospheric pollution (especially PM2.5), smoking and aging populati...

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Problems solved by technology

However, the current model to establish a model of inhalation respiratory system injury disease such as COPD model has two kinds of oronasal exposure system and whole body exposure (that is, the most common fume box or box), and the oronasal exposure system uses a tower chamber structure, the air flow in the exposure chamber is better, and the smoke is more uniform. However, the smoke concentration value of this method cannot be accurately monitored, the number of parallel experimental animals is limited, and the equipment cost is relatively expensive; The ventilation and gas quality of the box are poor, and it is not easy to control and monitor precise parameters. There are deficiencies such as poor repeatability and lack of standardized procedures and measurements. Can be self-made, so it is the most common in domestic laboratories

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