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Biomimetic chitosan filling agent for preventing capsule contracture and preparation method thereof

A technology of capsular contracture and chitosan, applied in the fields of medical formula, tissue regeneration, medical science, etc., can solve problems such as increased incidence of capsular contracture, poor effect, increased incidence of capsular contracture, etc., to prevent occurrence Development, reduction of inflammation, good physical barrier effect

Inactive Publication Date: 2018-07-06
SHANGHAI HAOHAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] (4) Infection Even if a hidden infection occurs in the surgical field, the incidence of postoperative capsular contracture will be greatly increased
[0012] (5) There are foreign bodies. If the gloves are stained with talcum powder, it will increase the incidence of postoperative capsular contracture
But with the emergence of bacterial resistance, long-term use may not be effective

Method used

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  • Biomimetic chitosan filling agent for preventing capsule contracture and preparation method thereof
  • Biomimetic chitosan filling agent for preventing capsule contracture and preparation method thereof
  • Biomimetic chitosan filling agent for preventing capsule contracture and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A biomimetic chitosan filler for preventing capsular contracture, comprising: 10wt‰ of hydroxybutyl chitosan gel, 10wt‰ of cross-linked sodium hyaluronate with a molecular weight of 2.5-6 million Daltons, 0.5 wt‰ polyethylene glycol, 0.02‰ sodium chloride, 0.03‰ potassium chloride, 1×10 10 Autologous adipose stem cells and phosphate buffer, the balance is water for injection, the amount of phosphate buffer added is to make the pH of the chitosan filler be 7.0, and finally prepared into 3mL chitosan filler, the chitosan filler The osmotic pressure of the agent is 300mOsmol / Kg.

[0041] The preparation method of above-mentioned chitosan filler is:

[0042] (1) Weigh the water for injection of 50wt% of the formula, and add the chitosan gel, cross-linked sodium hyaluronate, surfactant, isotonic regulator and autologous adipose stem cells into the container, according to the speed of 150rpm Stir evenly under the conditions of 5 hours and 20°C, add a pH regulator to adjust ...

Embodiment 2

[0045] A biomimetic chitosan filler for preventing capsular contracture, comprising: 0.005wt‰ of hydroxybutyl chitosan gel, 5wt‰ of cross-linked sodium hyaluronate with a molecular weight of 2.5-6 million Daltons, 100wt The mixture of ‰ butanediol and Tween 80, 50wt‰ of magnesium chloride, 1×10 5 Autologous adipose stem cells and boric acid, the balance is water for injection, the addition of boric acid is to make the pH of the chitosan filler be 6.5, and finally prepared into 3mL chitosan filler, the osmotic pressure of the chitosan filler is 270mOsmol / Kg.

[0046] The preparation method of above-mentioned chitosan filler is:

[0047] (1) Weigh the water for injection of 40wt% of the formula, and add the chitosan gel, cross-linked sodium hyaluronate, surfactant, isotonic regulator and autologous adipose stem cells into the container, according to the speed of 200rpm Stir evenly under the conditions of 6 hours and 25°C, add a pH regulator to adjust the pH to 6.5, and use a ...

Embodiment 3

[0050] A biomimetic chitosan filler for preventing capsular contracture, comprising: 5wt‰ of chitosan gel, 0.005wt‰ of cross-linked sodium hyaluronate with a molecular weight of 2.5-6 million Daltons, and 50wt‰ of Potassium chloride at temperature 80, 20wt‰, 1×10 10 Autologous adipose stem cells and hydrochloric acid, the balance is water for injection, the addition of hydrochloric acid is to make the pH of the chitosan filler be 7.5, and finally prepared into 3mL chitosan filler, the osmotic pressure of the chitosan filler is 320mOsmol / Kg.

[0051] The preparation method of above-mentioned chitosan filler is:

[0052] (1) Weigh the water for injection of 60wt% formula quantity, add chitosan gel, cross-linked sodium hyaluronate, surfactant, isotonic regulator and autologous adipose stem cells into the container together with the formula quantity, according to the speed of 100rpm Stir evenly under the conditions of 3 hours and 15°C, add a pH regulator to adjust the pH to 7.5...

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Abstract

The invention belongs to the technical field of plastic and cosmetic surgery, and particularly relates to a biomimetic chitosan filling agent for preventing capsule contracture and a preparation method thereof, wherein the biomimetic chitosan filling agent for preventing the capsule contracture comprises a chitosan gel, cross-linked sodium hyaluronate, a surfactant, an isotonicity adjusting agent,autologous fat stem cells, a pH adjuster, and water, and the pH adjuster is added according to an adding amount that allows the pH of the biomimetic chitosan filling agent to be 6.5 to 7.5. The biomimetic chitosan filling agent prepared by the method can reduce inflammation caused by postoperative silicone exudation and prevent the occurrence and development of the capsule contracture.

Description

technical field [0001] The invention belongs to the technical field of plastic surgery, and in particular relates to a bionic chitosan filler for preventing capsular contracture and a preparation method thereof. Background technique [0002] Breast augmentation with prosthesis has always been popular in plastic surgery, but there are many complications, and capsular contracture is an urgent problem to be solved. The incidence of capsular contracture is 2.8% to 20.4%. It is the most common complication after breast augmentation. It generally refers to the formation of a capsule around the prosthesis after breast augmentation. Capsular contracture can lead to hardening of the prosthesis, breast pain and deformation, and seriously affect the quality of life of patients. Therefore, it is of great significance to prevent the occurrence of capsular contracture. The pathogenesis of capsular contracture is related to many factors. With the progress of research, it is believed that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/20A61L27/50
CPCA61L27/20A61L27/3804A61L27/3839A61L27/50A61L2300/41A61L2430/04C08L5/08A61L27/26A61L27/3834A61L27/52A61L27/54A61L2400/06
Inventor 张堃陈晚华卜冰倩吴剑英张军东常臻杜鹏
Owner SHANGHAI HAOHAI BIOLOGICAL TECH
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