Method for synthesizing 1- chlorine-2-dihalogenated iodine

A synthesis method and a dihalogenation technology, which are applied in the field of one-pot synthesis of 1-chloro-2-iododihalides, can solve problems such as difficult operation, environmental pollution, and restrictions on large-scale application, and achieve simple reaction operation and high reaction efficiency. Mild conditions and good substrate adaptability
CN108276244AInactive Publication Date: 2018-07-13ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2018-07-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for synthesizing 1-chlorine-2-dihalogenated iodine as shown in formula (IV). The method comprises the following steps: mixing an olefin compound as shown in formula (I), an iodine source, tert-butyl hydroperoxide as shown in formula (II) and N-hydroxybenzotriazole as shown in formula (III) into an organic solvent, and reacting completely from the room temperature to a temperature lower than 50 DEG C, thereby obtaining reaction liquor A; adding acetyl chloride into reaction liquor A, completely reacting at the room temperature, and performing post-treatment on reaction liquor B to obtain a 1-chlorine-2-dihalogenated iodine compound. The method is safe and environmentally friendly, does not generate waste gas, and is more beneficial for being applied to pharmaceutical synthesis. And reaction conditions are gentle, substrate adaptation is good, and various substituent groups also can realize corresponding 1-chlorine-2-iodine halogenation.(The formulas is shown in the description.).
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Description

(1) Technical field

[0001] The invention specifically relates to a method for synthesizing 1-chloro-2-iododihalides in one pot. (2) Background technology

[0002] Dihalides are often key intermediates in the artificial synthesis of some natural products and drug molecules, and some halides are also very useful synthons in organic synthesis, so the development of novel dihalogenation reactions is important for both scientific research and practice. production is important. But so far, there are few reports on the synthetic methods of these compounds. The most common method is to directly halogenate carbon-carbon double bonds with simple halogens. Although this method is simple, it is not easy to operate and easily causes environmental pollution, which greatly limits the large-scale application of this method. (3) Contents of the invention

[0003] The object of the present invention is to provide a new method of 1-chloro-2-iodine dihalide, with olefin compound, iodine sou...

Claims

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