6-benayl aminopurine synthetic method

Abstract

The invention discloses a 6-benayl aminopurine synthetic method. The method takes hypoxanthine as a raw material, thionyl chloride is taken as a solvent, phosgene or diphosgene or triphosgene is takenas a chloride agent, 4-dimethylaminopyridine or dialkyl aminopyridine is taken as a catalyst for a reaction, after the reaction is completed, 6-chloropurine is obtained, distilled thionyl chloride and phosgene dissolved in thionyl chloride are completely used for a next reaction, and then the obtained 6-chloropurine and benzylamine are subjected to the reaction to synthesize 6-benayl aminopurineunder existence of triethylamine. During a reaction process, the used chloride agent solid triphosgene is completely decomposed to the phosgene dissolved in the solvent under existence of the catalyst4-dimethylaminopyridine, and no solid constituent is residual.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis of 6-benzylaminopurine. technical background [0002] The existing synthesis process is: hypoxanthine is used as a raw material, reacted with phosphorus oxychloride in the presence of N,N-dimethylaniline to obtain 6-chloropurine, and 6-chloropurine is then reacted with benzylamine in the presence of triethylamine The following reaction is carried out to synthesize 6-benzylaminopurine. The main problem of existing technology is: the first step reaction, uses greatly excess phosphorus oxychloride (both as chlorination reagent and also as solvent), and side reaction is many, and productive rate is low, and excessive phosphorus oxychloride can not be obtained by distillation. Recycling can only be decomposed with water, and a large amount of phosphorus-containing wastewater is discharged. N,N-dimethylaniline needs to be recycled, and the discharged wastewater also contains N,N-dimethylanil...

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Problems solved by technology

The main problem of existing technology is: the first step reaction, uses greatly excess phosphorus oxychloride (both as chlorination reagent and also as solvent), and side reaction is many, and productive rate is low, and excessive phosphorus oxychloride can not be obtained by distillation. Recycling can only be decomposed with water, and a large amount of phosphorus-containing wastewater is discharged. N,N-dimethylaniline needs to be recycled, and the discharged wastewater also contains N,N-dimethylaniline, which seriously pollutes the environment; the second step Reaction, in order to improve the reaction conversion rate and reaction speed, it is necessary to use an excessive amount of benzylamine, resulting in complicated separation and purification process