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A kind of nanostructure lipid carrier containing schisandra lignans compound and preparation method and determination method thereof

A technology of nanostructured lipids and schisandrin A, which is applied in liposome delivery, medical preparations of non-active ingredients, drug combinations, etc., can solve the problem of low bioavailability due to the lack of research reports on nanostructured lipid carriers , limited application and other issues, to achieve the effects of low drug side effects, prolonged action time, and high bioavailability

Active Publication Date: 2020-06-05
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Schisandrol A (schisandrol A), is a kind of lignan compound of Schisandra chinensis, is a kind of lignan compound isolated from the traditional Chinese medicine Schisandra chinensis, and its molecular formula is C 24 h 32 o 7 , with a relative molecular mass of 432.5, insoluble in water, low bioavailability, and fast metabolism, which limits its clinical application
[0005] After consulting patents and literature, there is no research report on nanostructured lipid carriers containing Schisandra lignans (such as Schizandrin A)

Method used

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  • A kind of nanostructure lipid carrier containing schisandra lignans compound and preparation method and determination method thereof
  • A kind of nanostructure lipid carrier containing schisandra lignans compound and preparation method and determination method thereof
  • A kind of nanostructure lipid carrier containing schisandra lignans compound and preparation method and determination method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Preparation of nanostructured lipid carrier containing Schisandrin A

[0049] The prescription is as follows:

[0050]

[0051] Mix Schisandrin A and lipids (glycerol monostearate and medium-chain triglycerides) and heat in a water bath to 75±1°C as the oil phase; add water for injection to Poloxamer 188, and stir evenly with ultrasonic After heating to 75±1°C, it is used as the water phase; under magnetic stirring, add the water phase dropwise to the oil phase at the same temperature, stir at a constant temperature for 10 minutes, and the stirring speed is 900r / min to make colostrum, and use an ultrasonic cell disruptor to sonicate while it is hot Disperse for 10 minutes (power of 750W, amplitude of 100%, interval of 3 seconds for every 3 seconds of ultrasound), and naturally cool and solidify at room temperature to obtain a nanostructured lipid carrier (SCH-NLC) containing schisandrin A.

Embodiment 2

[0052] Example 2: Preparation of nanostructured lipid carrier containing schisandrin A

[0053] The prescription is as follows:

[0054]

[0055]

[0056] The preparation method is the same as in Example 1.

Embodiment 3

[0057] Example 3: Preparation of nanostructured lipid carrier containing schisandrin A

[0058] The prescription is as follows:

[0059]

[0060] The preparation method is the same as in Example 1.

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Abstract

Belonging to the field of pharmaceutical preparations, the invention in particular relates to a nanostructure lipid carrier containing schisandra chinensis lignans, a preparation method and a determination method thereof. The nanostructure lipid carrier comprises: 10-24 weight parts of schisandra chinensis lignans, 240-360 weight parts of glyceryl monostearate, 40-120 weight parts of medium-chaintriglyceride, 300-500 parts of poloxamer 188, and 10 weight parts of water. The components and the content thereof in the nanostructure lipid carrier provided by the invention have complementary and synergistic effect, can increase the solubility of schisandra chinensis lignans and prolong the action time, also the nanostructure lipid carrier has good stability, high bioavailability and low drug toxic and side effect, at the same time has good average particle size, encapsulation rate, drug loading capacity and other indexes, does not isomerize or degrade easily, and has good stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a nanostructured lipid carrier containing schisandra lignan compounds, a preparation method and a measurement method thereof. Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease, is a chronic progressive mental degenerative disease characterized by cognitive dysfunction, emotional disturbance and abnormal mental behavior. With the acceleration of the aging process of the population, the incidence of Alzheimer's disease is increasing year by year. At present, there are 6 million senile dementia patients in my country, and it is predicted that the number will increase to 10.09 million by 2025. At the same time, liver disease is a common disease worldwide with a high incidence rate, such as alcoholic fatty liver, alcoholic hepatitis, liver cirrhosis, liver fibrosis and liver cancer. Both of the above two diseases have seriousl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/19A61K31/09A61K47/14A61K47/10A61K47/26A61P25/28A61P1/16G01N30/02
CPCA61K9/127A61K9/19A61K31/09A61K47/10A61K47/14A61K47/26G01N30/02
Inventor 李化牟倩倩杨滨李小芳付梅红方婧易红
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI