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An electrospun medical composite fiber drug film capable of loading multiple drugs and its preparation method

A composite fiber and medical technology, which is applied in the field of polyvinyl alcohol/polylactic acid microspheres/nano calcium phosphate medical composite fiber film and its preparation, to achieve the effect of improving repair effect, good application prospect and simple process

Active Publication Date: 2020-01-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the above-mentioned problems existing in the existing artificial medical dressings, to provide a composite fiber medical film capable of loading multiple drugs and its preparation method

Method used

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  • An electrospun medical composite fiber drug film capable of loading multiple drugs and its preparation method
  • An electrospun medical composite fiber drug film capable of loading multiple drugs and its preparation method
  • An electrospun medical composite fiber drug film capable of loading multiple drugs and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Nano-calcium phosphate was prepared by precipitation method at 37 °C. First prepare the Ca separately 2+ Calcium nitrate aqueous solution and PO with a concentration of 0.0334mol / L 4 3- Diammonium hydrogen phosphate aqueous solution with an ion concentration of 0.02mol / L, then heat and stir the prepared solution on a constant temperature magnetic stirrer at 37°C according to the Ca / P molar ratio of 1.67, and quickly pour the diammonium hydrogen phosphate aqueous solution into In the calcium nitrate aqueous solution, stir vigorously to mix evenly, add concentrated ammonia water dropwise to the solution to adjust the pH to 10-11, react at 37°C for 1 hour, centrifuge the milky white turbid liquid, rinse it with deionized water three times, and obtain a white precipitate of nano-calcium phosphate . Add 500mg of nano-calcium phosphate and 15mg of polyacrylic acid into 50mL of water, and ultrasonically disperse for 3min to obtain nano-calcium phosphate suspension.

[0031...

Embodiment 2

[0035] Adopt the method identical with embodiment 1 to prepare nano-calcium phosphate. Add 100mg of nano-calcium phosphate and 15mg of polyacrylic acid into 50mL of water, and ultrasonically disperse for 3 minutes to obtain a suspension of nano-calcium phosphate.

[0036] Add 50mg of polylactic acid into 5mL of dichloromethane, and continue to sonicate in an ultrasonic cleaner for 10-30min until the polylactic acid is completely dissolved. Immediately inject the obtained suspension into 125mL, 5mg / mL polyvinyl alcohol solution, stir at 1000r / min for 3h, and then ultrasonically disperse for 10min to obtain a suspension of porous polylactic acid microspheres.

[0037] Mix 5mL polylactic acid microsphere suspension and 5mL nano-calcium phosphate suspension evenly, then add 1.4g of polyvinyl alcohol, and stir at 80°C to obtain a composite spinning solution of polyvinyl alcohol, polylactic acid microspheres and nano-calcium phosphate . The composite spinning solution was injected...

Embodiment 3

[0040] Adopt the method identical with embodiment 1 to prepare nano-calcium phosphate. Add 100mg of nano-calcium phosphate and 15mg of polyacrylic acid into 50mL of water, and ultrasonically disperse for 3 minutes to obtain a suspension of nano-calcium phosphate.

[0041] Add 200mg of polylactic acid into 5mL of dichloromethane, and continue to sonicate in an ultrasonic cleaner for 10-30min until the polylactic acid is completely dissolved. Immediately inject the obtained suspension into 100 mL, 5 mg / mL polyvinyl alcohol solution, stir at 1000 r / min for 3 h, and ultrasonically disperse for 10 min to obtain a suspension of porous polylactic acid microspheres.

[0042] Mix 5mL polylactic acid microsphere suspension and 5mL nano-calcium phosphate suspension evenly, then add 0.7g of polyvinyl alcohol, and stir at 80°C to obtain a composite spinning solution of polyvinyl alcohol, polylactic acid microspheres and nano-calcium phosphate . The composite spinning solution was injecte...

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Abstract

The invention relates to an electrostatic spinning type medical composite fiber medicine membrane capable of loading multi-drugs and a preparation method of the electrostatic spinning type medical composite fiber medicine membrane. The preparation method comprises the following steps: firstly, preparing a polylactic acid microsphere suspension solution by adopting an emulsion and solvent volatilization method; then preparing a nano calcium phosphate suspension solution by adopting an ultrasound-assisted precipitation method; finally, mixing the polylactic acid microsphere suspension solution and the nano calcium phosphate suspension solution according to a ratio and adding a mixture into polyvinyl alcohol to prepare a mixed spinning solution; carrying out electrostatic spinning to obtain the composite fiber medicine membrane. In the process, different types of drugs also can be loaded in the polylactic acid microsphere suspension solution and the nano calcium phosphate suspension solution, so that the medicine membrane capable of releasing the multi-drugs can be obtained and a repairing effect on tissue defects is improved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a polyvinyl alcohol / polylactic acid microsphere / nano calcium phosphate medical composite fiber drug film capable of loading multiple drugs and a preparation method thereof. Background technique [0002] Soft tissue injury is a very common lesion. The soft tissue that people often say refers to the skin, subcutaneous tissue, muscles, tendons, ligaments, joint capsules, synovial bursa, nerves, blood vessels, etc. of the human body. Taking the skin as an example, it can protect various tissues and organs in the body from external mechanical and pathogenic invasion, and skin damage and defect will lead to a series of physiological and pathological problems. For large-area skin defects, in addition to autologous skin graft repair, artificial medical dressings can also protect damaged skin, provide a good physiological repair environment for wound healing, and there is no pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/34A61K47/02D04H1/4382D04H1/728A61P19/04A61P29/00
CPCA61K9/7007A61K47/02A61K47/32A61K47/34D04H1/4382D04H1/728
Inventor 韩颖超倪培龙戴红莲王欣宇
Owner WUHAN UNIV OF TECH