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A kind of low drug adsorption TPS and its preparation method and application

A drug and reaction technology, applied in the field of medical device materials, can solve the problems of reducing drug efficacy, inability to apply fat-soluble and water-soluble drugs at the same time, and achieve the effects of no pollution to the environment, easy large-scale continuous production, and not easy to precipitate

Active Publication Date: 2020-08-25
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above method is to change the connection mode of the catheter, which cannot be applied to both fat-soluble and water-soluble drugs, and the material PVC is more likely to absorb drugs and reduce drug efficacy.

Method used

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  • A kind of low drug adsorption TPS and its preparation method and application
  • A kind of low drug adsorption TPS and its preparation method and application

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preparation example Construction

[0030] The present invention also provides a preparation method of the above-mentioned low drug adsorption TPS, comprising the following steps:

[0031] After the pre-irradiated TPS is mixed with one of the organic peroxide initiators, TPS and reactive vinyl fluorosilicone oil, the low drug adsorption TPS is obtained through melt grafting reaction.

[0032] In the present invention, firstly, the pre-irradiated TPS is mixed with one of the organic peroxide initiators, TPS and reactive vinyl fluorosilicone oil to obtain a mixture.

[0033] In the present invention, the preparation of raw materials may also include auxiliary grafting monomers, that is, mixing pre-irradiated TPS with one of the organic peroxide initiators, TPS and reactive vinyl fluorosilicone oil to obtain a mixture.

[0034] After obtaining the mixture, the mixture is subjected to melt grafting reaction to obtain TPS with low drug adsorption.

[0035] The temperature of the melting grafting reaction is 160-240°...

Embodiment 1

[0042] Weigh 1000 grams of SEBS ( G1652), 15 grams of vinyl fluorosilicone oil (viscosity: 2000cp), 5 grams of dicumyl peroxide initiator and 12 grams of styrene are mixed in a high mixer, and then the blend is melted in a twin-screw Reactive extrusion yields low drug adsorption SEBS. The reaction extrusion grafting temperature is 200° C., the screw speed is 150 rpm, and the material residence time is 1.2 min. The modified SEBS was used to prepare corresponding disposable infusion tubes, and the adsorption properties of various drugs are listed in Table 1.

Embodiment 2

[0044] Weigh 1000 grams of SEPS ( G1650 M), 20 grams of vinyl fluorosilicone oil (viscosity: 4000cp), 4 grams of 2,5-dimethyl-2,5-di-tert-butylperoxyhexane initiator and 8 grams of vinylpyrrolidone in a high mixer The mixture was mixed in a twin-screw, and then the blend was melt-reactively extruded in a twin-screw to obtain SEPS with low drug adsorption performance. The reaction extrusion grafting temperature is 190° C., the screw speed is 100 rpm, and the material residence time is 2.5 minutes. The modified SEPS was prepared into corresponding disposable infusion tubes, and the adsorption properties of various drugs are listed in Table 1.

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Abstract

The present invention provides that the low drug adsorption TPS provided by the present invention is obtained by melting and grafting after mixing pre-irradiated TPS with one of the organic peroxide initiators, TPS and reactive vinyl fluorosilicone oil. In the twin-screw extruder, reactive vinyl fluorosilicone oil is grafted on the TPS molecular chain by melt reaction extrusion to reduce the adsorption of TPS devices to drugs and improve drug efficacy during input or storage. It has the advantages of not easy to precipitate, long-lasting anti-drug adsorption performance, etc. The low-drug adsorption TPS prepared by the invention can be applied to both fat-soluble and water-soluble drugs, and can be used in the fields of medical devices such as drug infusion and storage devices. The product has low drug adsorption and long-lasting and stable performance. In addition, the low-drug adsorption TPS has a simple preparation method, has no pollution to the environment, and is easy to realize large-scale continuous production.

Description

technical field [0001] The invention belongs to the technical field of medical device materials, and in particular relates to a low-drug adsorption TPS and its preparation method and application. Background technique [0002] TPS (styrenic thermoplastic elastomer) is a styrene-based thermoplastic elastomer. Styrene-based thermoplastic elastomers are generally prepared from styrene, butadiene or isoprene by anionic polymerization techniques using alkyllithium as an initiator. Styrenic thermoplastic elastomers are divided into styrene-isoprene-styrene block copolymers, styrene-butadiene-styrene block copolymers and their corresponding hydrogenated products according to the block components. Plasticizers can be widely used in medical devices such as drug infusion devices, blood infusion devices and other fields. However, during drug delivery and storage, both fat-soluble and water-soluble drugs will be adsorbed on the surface of TPS devices, which affects the clinical efficac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F291/16C08F212/08C08F226/10C08G81/02
CPCC08F279/02C08F283/124C08G81/022C08F212/08C08F226/10
Inventor 石恒冲栾世方殷敬华陈家悦杨华伟闫顺杰
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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