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Preparation method of medical adhesive

An adhesive and a technology for preparation steps, applied in the field of medical materials, can solve the problems of good biocompatibility, low bonding strength and high preparation cost of bioadhesives, and achieve good biodegradability and biocompatibility properties, easy availability of raw materials, and the effect of improving antibacterial properties

Inactive Publication Date: 2018-08-03
佛山杰致信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problems of good biocompatibility, low bonding strength, high preparation cost and poor antibacterial property of biological adhesives, a preparation method of medical adhesives is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] According to the mass ratio of 1:20, weigh the spider silk and add it to hexafluoroisopropanol, stir until the spider silk dissolves, filter the filtrate through a metal filter, and obtain the spider silk protein solution; add gallic acid twice the mass of the spider silk to three mouthfuls Place the flask in an ice bath, add dicyclohexylcarbodiimide and dropwise spider silk protein solution to the three-necked flask under the protection of nitrogen, control the dropping rate to 3g / min, and move it into the water bath after the addition , heated to 60°C, stirred for 10 minutes, then added 5% tea polyphenols of the quality of the spider silk protein solution and 0.1% catalyst of the quality of the spider silk protein solution, continued to stir and react for 30 minutes, cooled to room temperature after the reaction and discharged to obtain the reactant ; Remove the hexafluoroisopropanol by rotary evaporating the reactant, wash with absolute ethanol, and freeze-dry after w...

example 2

[0020] According to the mass ratio of 1:20, weigh the spider silk and add it to hexafluoroisopropanol, stir until the spider silk dissolves, filter the filtrate through a metal filter, and obtain the spider silk protein solution; add gallic acid twice the mass of the spider silk to three mouthfuls Place the flask in an ice bath, add dicyclohexylcarbodiimide and dropwise spider silk protein solution to the three-necked flask under the protection of nitrogen, control the dropping rate to 4g / min, and move it into the water bath after the addition , heated to 70°C, stirred for 15 minutes, then added 6% tea polyphenols of the quality of the spider silk protein solution and 0.2% of the catalyst of the quality of the spider silk protein solution, continued to stir and react for 40 minutes, cooled to room temperature after the reaction and discharged to obtain the reactant ; Remove the hexafluoroisopropanol by rotary evaporating the reactant, wash with absolute ethanol, and freeze-dry ...

example 3

[0022] According to the mass ratio of 1:20, weigh the spider silk and add it to hexafluoroisopropanol, stir until the spider silk dissolves, filter the filtrate through a metal filter, and obtain the spider silk protein solution; add gallic acid twice the mass of the spider silk to three mouthfuls Place the flask in an ice bath, add dicyclohexylcarbodiimide and dropwise spider silk protein solution to the three-necked flask under the protection of nitrogen, control the dropping rate to 5g / min, and move it into the water bath after the addition , heated to 80°C, stirred for 20 minutes, then added 7% tea polyphenols by quality of the spider silk protein solution and 0.3% catalyst by the quality of the spider silk protein solution, continued to stir and react for 50 minutes, cooled to room temperature after the reaction and discharged to obtain the reactant ; Remove the hexafluoroisopropanol by rotary evaporating the reactant, wash with absolute ethanol, and freeze-dry after washi...

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Abstract

The invention belongs to the field of medical materials and particularly relates to a preparation method of a medical adhesive. The main raw materials of the medical adhesive prepared by the preparation method are spider silk and gallic acid, wherein the spider silk has good adhesion property. The spider silk is rich in amino groups and can react with the gallic acid under the action of dicyclohexylcarbodiimide, and the amino-acid high polymer generated by the reaction has an adhesive effect; in addition, tea polyphenol is added during the reaction, so that the medical adhesive can achieve a specific antibacterial property, and the stability can also be improved. The medical adhesive provided by the invention has good biodegradability and biological compatibility, the raw materials are cheap and are easily obtained, and the reaction raw materials have no toxicity.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of a medical adhesive. Background technique [0002] Currently commonly used medical adhesives include: (1) Chemical adhesives: α-cyanoacrylate adhesives are the earliest and most widely used tissue adhesives. This kind of adhesive is characterized by fast bonding speed, high bonding strength, and relatively weak tissue reaction, and is the main variety for clinical application. However, its viscosity and polymerization speed are difficult to control, and the adhesive layer is brittle, and it has slight tissue toxicity. (2) Bioadhesives: Refers to viscous products extracted from human or animal blood or prepared by biosynthetic methods. Currently, the fibrin adhesives that have been marketed and used clinically are mainly extracted and prepared. Fibrin glue has good biocompatibility, but the bond strength is not high, the preparation cost is hig...

Claims

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Application Information

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IPC IPC(8): C09J189/00C07K1/107
CPCC09J189/00C07K1/1077
Inventor 王玉环
Owner 佛山杰致信息科技有限公司
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