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Novel degradable polyurethane biological material and preparation method and application thereof

A biomaterial, polyurethane technology, applied in the field of biomedical polymer materials, can solve the problems of lack of selective arrangement and combination of blocks, difficult to control material properties, etc., and achieve the effects of high surface energy, high crystallinity, and enhanced mechanical strength

Inactive Publication Date: 2018-08-17
许开天
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, almost all conventional segmented polyurethanes are synthesized by coupling the terminal hydroxyl groups of diols or / and polyols with isocyanates using diisocyanates as coupling agents, even though this method provides materials with improved properties, But in fact, it lacks block selectivity and regular arrangement and combination, and can only be assembled and connected in a random way to form a block copolymer (that is, a traditional random block polyurethane polymer, abbreviated: RanPU, such as figure 1 shown), and this kind of random structure will make the material properties difficult to control

Method used

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  • Novel degradable polyurethane biological material and preparation method and application thereof
  • Novel degradable polyurethane biological material and preparation method and application thereof
  • Novel degradable polyurethane biological material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Synthesis of Alternating Block Polyurethanes (Alt-PU) and Random Block Polyurethanes (Ran-PU) Based on Aliphatic Polyesters and Hydrophilic Polyethers:

[0059] Dissolve the aliphatic polyester diol in the organic solvent (chloroform) in the three-necked flask first, and then use the hydrophilic polyether-diisocyanate prepared by the end-capping reaction, according to the ratio of 1:1 with the diol The molar equivalent is slowly dropped into the flask, and after reacting at 30-100° C. for 8-72 hours, the alternating block polyurethane Alt-PU is obtained. Above-mentioned reaction also can directly be carried out in reaction raw material body, also can use the organotin catalyst of 1 / 100000 to 1 / 100,000 (weight ratio), as 2-ethylhexanoate tin, butyltin dilaurate etc., reflect The hydroxyl and isocyanate groups in the system should have an equal molar ratio.

[0060] Use aliphatic polyester diol and hydrophilic polyether as the reaction body, add tin-containing catalyst, ...

Embodiment 2

[0063] Alternating block polyurethane (Alt-PU) and random block polyurethane (Ran-PU) biomaterials prepared in Example 1 are applied to the preparation of nerve repair sockets:

[0064] Porous nerve repair sockets were prepared by using dip coating and salt immersion methods, using a stainless steel wire with an outer diameter of 1.5 mm as a mold, and then the polymer coating on the resulting mold was air-dried for 2 days, vacuum-dried for 2 days, and then desiccated. The salt was leached out in deionized water, freeze-dried and demoulded to obtain the nerve repair socket.

[0065] Nerve repair sleeve, also known as nerve repair catheter or nerve repair sheath; it can also be called nerve repair covering sheet and nerve protection open tube. The nerve repair sleeve prepared by the alternating block polyurethane (Alt-PU) has a microporous pipeline structure, a microporous sheet structure and a microporous opening with a porosity of 10-99% and a pore size of 100 nm to 500 μm (mi...

Embodiment 3

[0083] The alternate block polyurethane (Alt-PU) biomaterial prepared in Example 1 is applied to the preparation of eyelid support, and the manufacturing method is liquid-solid phase separation and freeze-drying method:

[0084] Put a certain amount of Alt-PU material into a beaker and add organic solvent until Alt-PU completely dissolves into a transparent solution. Pour the solution into a stainless steel mold, control the thickness of the poured liquid surface, place the mold containing the solution in an ice-water mixing incubator at -20-0°C for 1-10 hours, take it out and place it in a -10-4°C for 1- After 24 hours, move to a freeze dryer for freeze-drying, then freeze-dry for 1-24 hours, take out the stainless steel mold and put it in a normal temperature vacuum dryer to dry for 1-48 hours, take out the molded bracket, and then cut the bracket into 1cm 2 Bracket, get 0.7mm×1cm 2 Eyelid implants. The eyelid implant bracket has a porous film structure with a porosity of ...

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Abstract

The invention discloses a novel degradable polyurethane biological material, a preparation method thereof and an application thereof in the preparation of degradable implantable / non-implantable medical instruments. The novel material is an alternatively segmented polyurethane polymer material prepared from biodegradable polyester glycol and hydrophilic polyether glycol and is prepared through selective coupling reactions between aliphatic polyester glycol and diisocyanate terminated hydrophilic polyether (or between aliphatic polyester glycol and diisocyanate terminated aliphatic polyester blocks). The biological material has a controllable and predictable chemical structure and regular polymer chain arrangement, also has a surface micro-phase patterned structure, can be widely used in many medical and non-medical instrument fields, and has an excellent performance in application fields such as peripheral nerve repairing conduit, meniscus repair, anti-adhesion film, meninx, eyelid reconstruction stent, wound dressing, composite bone porous repairing stent, soft / hard tissue regeneration, and the like.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a novel biodegradable polyurethane biomaterial and its preparation method and application. Background technique [0002] Biodegradable block polyurethane is a class of widely used biomaterials. At present, several corresponding implanted medical devices have been approved by European CE and US FDA for human use. Due to its excellent hemocompatibility, excellent mechanical and processing properties, it is widely used in tissue engineering, regenerative medicine, controlled drug delivery, wound healing and other applications. However, almost all conventional segmented polyurethanes are synthesized by coupling the terminal hydroxyl groups of diols or / and polyols with isocyanates using diisocyanates as coupling agents, even though this method provides materials with improved properties, But in fact, it lacks block selectivity and regular arrangement and combination, and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/72C08G18/48C08G18/42A61L31/14A61L31/06A61L27/58A61L27/18A61L17/10A61L15/64A61L15/26
CPCA61L15/26A61L15/64A61L17/10A61L27/18A61L27/50A61L27/58A61L27/60A61L31/06A61L31/148A61L2430/02A61L2430/32A61L2430/34C08G18/3206C08G18/4018C08G18/42C08G18/4277C08G18/428C08G18/48C08G18/4825C08G18/4833C08G18/4854C08G18/72C08G2230/00C08L75/06C08L75/08C08L75/04
Inventor 许开天
Owner 许开天
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