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Foam hand washing liquid for preventing and treating hand-foot-and-mouth disease, and production method thereof

A technology of hand, foot and mouth disease and hand sanitizer, applied in the field of foam hand sanitizer, can solve the problems of clinical application and dosage form development limitations, limit oral absorption rate and other problems, achieve the effect of reducing skin dryness, good wettability, and convenient and simple use

Inactive Publication Date: 2018-08-24
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, TJAB-1099 is a poorly water-soluble compound, and its water solubility limits its oral absorption rate, which greatly limits its clinical application and dosage form development

Method used

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  • Foam hand washing liquid for preventing and treating hand-foot-and-mouth disease, and production method thereof
  • Foam hand washing liquid for preventing and treating hand-foot-and-mouth disease, and production method thereof
  • Foam hand washing liquid for preventing and treating hand-foot-and-mouth disease, and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: a kind of foam hand sanitizer of preventing and treating hand-foot-mouth disease

[0033] Preparation:

[0034] Add 100μg Span 20 into 100ml ethanol and mix well, then add 4.25mg TJAB-1099 (for example, R in TJAB-1099 used here is H), stir to make it completely dissolve to make A solution; take 3ml glycerin, propylene glycol 2ml, 0.1ml of essence and 1ml of A solution were dissolved in 20ml of ethanol, and mixed to make B solution; then 40g of surfactant APG-1200 was added to 34.9ml deionized water while stirring, and fully mixed to make C solution; finally Add all the C solution to the B solution, stir while adding, and adjust the pH to about 8 with citric acid to form a uniform hand sanitizer.

[0035] By the preparation method of the liquid hand sanitizer of the present embodiment, it can be known that the composition of the foam hand sanitizer of the present embodiment 1 is as follows:

[0036] TJAB-1099: 0.00004%, Span20: 0.000001%, Surfactant APG12...

Embodiment 2

[0038] The composition of the hand sanitizer of embodiment 2 is as follows:

[0039] TJAB-1099: 0.00002%, Span20: 0.000003%, Surfactant APG1200: 10%, Ethanol: 30%, Glycerin: 1%, Propylene Glycol: 1%, Fragrance: 0.5%, Citric Acid: 0.1%, Deionized Water: About 57.3%.

Embodiment 3

[0040] The composition of the hand sanitizer of embodiment 3 is as follows:

[0041] TJAB-1099: 0.00006%, Span20: 0.000005%, Surfactant APG1200: 20%, Ethanol: 40%, Glycerin: 4%, Propylene Glycol: 3%, Fragrance: 1%, Citric Acid: 0.4%, Deionized Water: About 31.6%.

[0042] Example 1 below illustrates the effectiveness detection method and the result of hand sanitizer inhibiting hand-foot-mouth disease-causing virus with Example 1:

[0043] 1. Culture of RD cells

[0044]Thaw RD cells frozen in liquid nitrogen (purchased from the Cell Bank of the Chinese Academy of Medical Sciences) in a 37°C water bath and add them to a culture bottle filled with 20ml of medium. The medium component is DMEM (Dulbecco's modifiedeagle medium) +10% fetal bovine serum (Fetal Bovine Serum, FBS) +1% penicillin and streptomycin (Penicillin-Streptomycin, PS), 37°C, 5% CO 2 to cultivate.

[0045] 2. Amplification of EV71 virus

[0046] When the cells grow to 90% fullness, add 200 μL of EV71 virus (...

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Abstract

The invention discloses a foam hand washing liquid for preventing and treating hand-foot-and-mouth disease, and a production method thereof. According to the present invention, the foam hand washing liquid can significantly inhibit the viruses of hand-foot-and-mouth disease, wherein the effective component TJAB-1099 can achieve the antiviral effect at the [mu]M level, and has effects of long-acting bacterial inhibition and skin protection; and the foam hand washing liquid is especially suitable for children.

Description

technical field [0001] The invention relates to foam hand sanitizer, more specifically, to a foam hand sanitizer which can prevent and treat hand, foot and mouth disease, and is especially suitable for children. Background technique [0002] Human hand-foot-mouth disease (HFMD) is an acute infectious disease caused by a variety of enteroviruses, among which enterovirus 71 (EV 71) is the most common in my country. Hand, foot and mouth disease is distributed all over the world, and its incidence has been on the rise in recent years. It can be sporadic or epidemic. The onset season is mostly in summer. The incidence rate is highest in children under five years old, and older children and adults can also be infected. Fever symptoms appear at the onset of the disease, scattered herpes appear on the oral mucosa, maculopapules and herpes appear on the hands, feet and buttocks, and there may be inflammatory flushes around the herpes, and there is less fluid in the pustules. Accompa...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/365A61K8/34A61K8/60A61K8/04A61Q17/02A61Q19/10A61P31/14A61K31/4439
CPCA61Q17/02A61Q19/10A61K8/046A61K8/34A61K8/345A61K8/365A61K8/4946A61K8/60A61K8/602A61K31/4439
Inventor 饶子和杨诚郭宇王淑艳毛永红马海秋蔡岩汪颖张玉普张金敏李玉彩左臣强
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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