A kind of zinc fluconazole decavanadate compound and its application
A zinc fluconazole decavanadate compound and molecular technology, applied in the field of medicinal chemistry, can solve the problems of few types of antifungal drugs, increased drug resistance and the like
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Embodiment 1
[0026] Example 1 Preparation of zinc fluconazole decavanadate compound ZnFLC
[0027] Synthesis of ZnFLC:
[0028] 1) Zn(OAc) 2 2H 2 O 0.2 mmol, NaVO 3 Add 0.36 mmol and fcz0.1 mmol to 7mL water and stir for 1 hour, put it into a polytetrafluoroethylene reaction kettle, put it in an oven at 120 ℃ for 6 days, and slowly cool to room temperature to form orange crystal Zn 3 (fcz) 6 V 10 o 28 10H 2 O, the yield is 68.9%.
[0029] 2) Characterization of ZnFLC
[0030]The single crystal data for the zinc fluconazole decavanadate compound were collected on a German Bruker X-ray diffractometer (singlecrystal X-ray diffraction), 300K, MoK. rays (λ=0.71073Å). Calibration is performed using φ scans. And the crystal structure was solved by the direct method through the SHELEXL-97 program, and refined by the full matrix least squares method SHELEXL-97. The temperature factors for non-hydrogen atoms were corrected for anisotropy. The detailed crystal determination data are sho...
Embodiment 2
[0033] Embodiment 2 Culture medium preparation
[0034] 1. SDA medium: Add 39g of SDA powder into 1000ml of purified water, heat and dissolve at 115°C for 30 minutes, and sterilize by autoclaving. When the temperature of the medium drops to about 50°C, pour it into a sterilized petri dish to make a plate, Isolation and storage of strains;
[0035] 2. SDB medium: Add 24g of SDB powder to 1000ml of purified water, heat and dissolve at 115°C for 30 minutes, sterilize by autoclaving, store in centrifuge tubes after culture, and enrich and activate the strain;
[0036] 3. RPMI-1640 liquid medium: 10.4g RPMI-1640 powder and 34.53g MOPS, add 900ml sterile distilled water, stir gently until dissolved, adjust the pH value to 7.0 with 1M NaOH at 25°C, and adjust the volume to 1000ml , sterilized by filtration with a 0.22 μm microporous membrane, aliquoted into sterile bottles, and stored at -20°C for later use.
Embodiment 3
[0037] Example 3 strain activation
[0038] Add 0.2ml of SDB liquid base to the freeze-dried strain tube, suspend it sufficiently to make a bacterial suspension, and take 0.1ml of the liquid to activate the strain on the SDA plate and slant medium at 35°C and humidity 60%.
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