Hollow slow-release microsphere used for loading medicine and preparation method thereof

A slow-release microsphere and hollow technology, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low loading and slow drug loading, and achieve the preparation method It has the effect of low price and easy industrial production.

Active Publication Date: 2018-08-28
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a hollow slow-release microsphere for drug loading and it

Method used

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  • Hollow slow-release microsphere used for loading medicine and preparation method thereof
  • Hollow slow-release microsphere used for loading medicine and preparation method thereof
  • Hollow slow-release microsphere used for loading medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1:

[0031] The preparation method of hollow sustained-release microspheres for drug loading of this embodiment includes the following steps:

[0032] (1) Prepare polystyrene microspheres by emulsification and crosslinking method, add polystyrene microspheres and emulsifier into oil phase paraffin, dissolve the shell polymer material in water and add dropwise to the oil phase paraffin, stir After emulsification, it was cooled to below 5°C in an ice-water bath, glutaraldehyde was added dropwise for cross-linking for 0.5h, then acetone was added, and solid microspheres were obtained after layered filtration.

[0033] Wherein, preparing polystyrene microspheres includes the following steps:

[0034] (11) Mix sodium lauryl sulfate with a concentration of 0.015g / mL and potassium persulfate with a concentration of 0.012g / mL in a volume ratio of 85:15, fill with inert gas and heat and stir under a water bath at 60℃ 20min, the stirring speed is 200rpm; the monomer styrene is d...

Example Embodiment

[0039] Example 2:

[0040] The preparation method of hollow sustained-release microspheres for drug loading of this embodiment includes the following steps:

[0041] (1) Prepare polystyrene microspheres by emulsification and crosslinking method, add polystyrene microspheres and emulsifier into oil phase paraffin, dissolve the shell polymer material in water and add dropwise to the oil phase paraffin, stir After emulsification, it was cooled to below 5°C in an ice water bath, glutaraldehyde was added dropwise for cross-linking for 2 hours, then acetone was added, and solid microspheres were obtained after layered filtration.

[0042] Wherein, preparing polystyrene microspheres includes the following steps:

[0043] (11) Mix sodium lauryl sulfate with a concentration of 0.02g / mL and potassium persulfate with a concentration of 0.018g / mL in a volume ratio of 95:5, fill with inert gas and heat and stir under a water bath at 90°C 5min, the stirring speed is 1000rpm; the monomer styrene is...

Example Embodiment

[0048] Example 3:

[0049] The preparation method of hollow sustained-release microspheres for drug loading of this embodiment includes the following steps:

[0050] (1) Prepare polystyrene microspheres by emulsification and crosslinking method, add polystyrene microspheres and emulsifier into oil phase paraffin, dissolve the shell polymer material in water and add dropwise to the oil phase paraffin, stir After emulsification, it was cooled to below 5°C in an ice-water bath, glutaraldehyde was added dropwise for cross-linking for 1 hour, then acetone was added, and solid microspheres were obtained after layered filtration.

[0051] Wherein, preparing polystyrene microspheres includes the following steps:

[0052] (11) Mix sodium lauryl sulfate with a concentration of 0.018g / mL and potassium persulfate with a concentration of 0.015g / mL in a volume ratio of 90:10, fill with inert gas and heat and stir in a water bath at 80°C 15min, the stirring speed is 500rpm; the monomer styrene is d...

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Abstract

The invention discloses a hollow slow-release microsphere used for loading medicine and a preparation method thereof, and belongs to the technical field of medical slow-release microspheres. The method comprises the steps that an emulsification-crosslinking method is adopted to coat a shell-layer polymer material on the surface of a polystyrene microsphere to obtain the core-shell structure microsphere with the polystyrene microsphere as the core and with gelatin, sodium alginate tech grade, chitosan and polylactic acid as the shell, then the core polystyrene microsphere is immersed, dissolvedand removed through tetrahydrofuran, crosslinking and solidification are carried out on the microsphere to obtain the hollow slow-release microsphere, then the medicine is loaded on the hollow-structure microsphere, and the drug loading capacity of the medicine is greatly increased.

Description

technical field [0001] The invention relates to the technical field of preparation of medical sustained-release microspheres, in particular to a hollow sustained-release microsphere for drug loading and a preparation method thereof. Background technique [0002] As a drug carrier, microspheres can embed drugs well, control the release rate of drugs, improve the utilization rate of drugs, and reduce the harm of drugs to the human body. Therefore, drug-loaded microspheres have been widely studied and applied in the medical field. The composition of the drug-loaded microspheres can be absorbed into the microspheres formed by the polymer material, or the drug can be evenly distributed in the polymer material to form the microspheres. The release can maintain the effective concentration of the drug in the body for a long time, which has a good prolongation effect on the drug effect, and at the same time, reduces or even avoids the adverse reactions caused by the drug to the body,...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/42A61K47/36A61K47/34A61K38/18
CPCA61K9/5031A61K9/5036A61K9/5057A61K9/5089A61K38/1875
Inventor 雷霆李丽尹乒肖涛刘立宏吴运香
Owner CENT SOUTH UNIV
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