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Hollow slow-release microsphere used for loading medicine and preparation method thereof

A slow-release microsphere and hollow technology, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low loading and slow drug loading, and achieve the preparation method It has the effect of low price and easy industrial production.

Active Publication Date: 2018-08-28
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a hollow slow-release microsphere for drug loading and its preparation method to solve the problems of low drug loading and slow drug loading speed of existing microspheres

Method used

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  • Hollow slow-release microsphere used for loading medicine and preparation method thereof
  • Hollow slow-release microsphere used for loading medicine and preparation method thereof
  • Hollow slow-release microsphere used for loading medicine and preparation method thereof

Examples

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Effect test

Embodiment 1

[0031] The preparation method of the hollow sustained-release microspheres for drug loading in this embodiment comprises the following steps:

[0032] (1) Polystyrene microspheres are prepared by emulsification cross-linking method, polystyrene microspheres and emulsifier are added to oil phase paraffin, the shell polymer material is dissolved in water and then added dropwise to oil phase paraffin, stirring After emulsification, cool in an ice-water bath to below 5°C, add glutaraldehyde dropwise for cross-linking for 0.5 h, then add acetone, and obtain solid microspheres after layered filtration.

[0033] Wherein, preparing polystyrene microspheres comprises the following steps:

[0034] (11) Mix sodium lauryl sulfate with a concentration of 0.015g / mL and potassium persulfate with a concentration of 0.012g / mL according to the volume ratio of 85:15, fill with inert gas and heat and stir in a water bath at 60°C 20min, the stirring speed is 200rpm; the monomer styrene is dissolv...

Embodiment 2

[0040] The preparation method of the hollow sustained-release microspheres for drug loading in this embodiment comprises the following steps:

[0041] (1) Polystyrene microspheres are prepared by emulsification and cross-linking method, polystyrene microspheres and emulsifier are added to the oil phase paraffin, the shell polymer material is dissolved in water and then added dropwise to the oil phase paraffin, stirring After emulsification, cool in an ice-water bath to below 5°C, add glutaraldehyde dropwise for cross-linking for 2 hours, then add acetone, and obtain solid microspheres after layered filtration.

[0042] Wherein, preparing polystyrene microspheres comprises the following steps:

[0043] (11) Mix sodium lauryl sulfate with a concentration of 0.02g / mL and potassium persulfate with a concentration of 0.018g / mL according to a volume ratio of 95:5, fill with inert gas and heat and stir in a water bath at 90°C 5min, the stirring speed is 1000rpm; the monomer styrene ...

Embodiment 3

[0049] The preparation method of the hollow sustained-release microspheres for drug loading in this embodiment comprises the following steps:

[0050] (1) Polystyrene microspheres are prepared by emulsification and cross-linking method, polystyrene microspheres and emulsifier are added to the oil phase paraffin, the shell polymer material is dissolved in water and then added dropwise to the oil phase paraffin, stirring After emulsification, cool in an ice-water bath to below 5°C, add glutaraldehyde dropwise for cross-linking for 1 hour, then add acetone, and obtain solid microspheres after layered filtration.

[0051] Wherein, preparing polystyrene microspheres comprises the following steps:

[0052] (11) Mix sodium lauryl sulfate with a concentration of 0.018g / mL and potassium persulfate with a concentration of 0.015g / mL at a volume ratio of 90:10, fill with inert gas and heat and stir in a water bath at 80°C 15min, the stirring speed is 500rpm; the monomer styrene is dissol...

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Abstract

The invention discloses a hollow slow-release microsphere used for loading medicine and a preparation method thereof, and belongs to the technical field of medical slow-release microspheres. The method comprises the steps that an emulsification-crosslinking method is adopted to coat a shell-layer polymer material on the surface of a polystyrene microsphere to obtain the core-shell structure microsphere with the polystyrene microsphere as the core and with gelatin, sodium alginate tech grade, chitosan and polylactic acid as the shell, then the core polystyrene microsphere is immersed, dissolvedand removed through tetrahydrofuran, crosslinking and solidification are carried out on the microsphere to obtain the hollow slow-release microsphere, then the medicine is loaded on the hollow-structure microsphere, and the drug loading capacity of the medicine is greatly increased.

Description

technical field [0001] The invention relates to the technical field of preparation of medical sustained-release microspheres, in particular to a hollow sustained-release microsphere for drug loading and a preparation method thereof. Background technique [0002] As a drug carrier, microspheres can embed drugs well, control the release rate of drugs, improve the utilization rate of drugs, and reduce the harm of drugs to the human body. Therefore, drug-loaded microspheres have been widely studied and applied in the medical field. The composition of the drug-loaded microspheres can be absorbed into the microspheres formed by the polymer material, or the drug can be evenly distributed in the polymer material to form the microspheres. The release can maintain the effective concentration of the drug in the body for a long time, which has a good prolongation effect on the drug effect, and at the same time, reduces or even avoids the adverse reactions caused by the drug to the body,...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/42A61K47/36A61K47/34A61K38/18
CPCA61K9/5031A61K9/5036A61K9/5057A61K9/5089A61K38/1875
Inventor 雷霆李丽尹乒肖涛刘立宏吴运香
Owner CENT SOUTH UNIV
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