A kind of drug delivery system based on stannous sulfide quantum dots and preparation method thereof
A technology of stannous sulfide and drug delivery system, applied in the field of tumor treatment, can solve the problem of expensive black phosphorus and achieve high clinical value, high chemical stability, and simple preparation
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0037] In a second aspect, the present invention provides a method for preparing a drug delivery system based on stannous sulfide quantum dots, comprising the following steps:
[0038] (1) Grind the stannous sulfide block for 20-60 minutes, disperse it in an organic solvent, and ultrasonicate it in a water bath at 5°C-10°C for 8-12 hours, then centrifuge to collect the precipitate, and dry it to obtain stannous sulfide quantum dots ;
[0039] (2) Disperse the stannous sulfide quantum dots in water to obtain an aqueous dispersion of stannous sulfide quantum dots, then add folic acid-modified polyethylene glycol to the aqueous dispersion, stir for 10-16 hours, and centrifuge Collect the precipitate to obtain the stannous sulfide quantum dots whose surface is coated with folic acid-modified polyethylene glycol;
[0040] (3) The stannous sulfide quantum dots of polyethylene glycol modified with folic acid on the surface are dispersed in water, and anticancer drugs are added, afte...
Embodiment 1
[0057] A preparation method of a drug delivery system based on stannous sulfide quantum dots, comprising the following steps:
[0058] (1) After grinding the stannous sulfide block for 30 minutes, disperse it in isopropanol to obtain a dispersion with a concentration of 1 mg / mL; the above-mentioned dispersion is ultrasonicated by a probe for 5 hours, and the probe power of the probe ultrasonic is 360w. During the ultrasonic process, keep the temperature at 5-10°C. During the period, when the temperature rises, use an ice pack to cool down; then ultrasonicate the dispersion in the water bath for 8 hours to obtain the ultrasonically dispersed liquid. The temperature of the ultrasonic bath in the water bath is kept at 5-10°C °C, when the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 5-10 °C; centrifuge the ultrasonically dispersed liquid at a speed of 15,000 rpm for 0.5 h, take the supernatant, and the...
Embodiment 2
[0063] A preparation method of a drug delivery system based on stannous sulfide quantum dots, comprising the following steps:
[0064] (1) After grinding the stannous sulfide block for 40 minutes, disperse it in nitrogen methyl pyrrolidone to obtain a dispersion solution with a concentration of 1 mg / mL; the above dispersion solution is ultrasonicated by a probe for 8 hours, and the power of the probe ultrasonic probe is 150w. Keep the temperature at 10°C during the ultrasonication process of the probe. During the period, when the temperature rises, use an ice pack to cool down; then ultrasonicate the dispersion in a water bath for 12 hours to obtain an ultrasonicated dispersion, and keep the temperature of the ultrasonic bath at 5-10°C , when the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 5-10°C; centrifuge the ultrasonically dispersed liquid at a speed of 13,000 rpm for 1 hour, take the supernat...
PUM
| Property | Measurement | Unit |
|---|---|---|
| size | aaaaa | aaaaa |
| size | aaaaa | aaaaa |
| size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More